Telbivudine therapy may shape CD4+ T-cell response to prevent liver fibrosis in patients with chronic hepatitis B

2014 ◽  
Vol 35 (3) ◽  
pp. 834-845 ◽  
Author(s):  
Jing Li ◽  
Minglei Jia ◽  
Yun Liu ◽  
Weimin She ◽  
Lei Li ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
T Cell ◽  
Liver Fibrosis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Cell Response ◽  
T Cell Response ◽  
Cd4 T Cell

scholarly journals Blockade of Tim-3 signaling restores the virus-specific CD8+T-cell response in patients with chronic hepatitis B

2012 ◽  
Vol 42 (5) ◽  
pp. 1180-1191 ◽  
Author(s):  
Wei Wu ◽  
Yu Shi ◽  
Shuping Li ◽  
Yun Zhang ◽  
Yanning Liu ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
T Cell ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Cell Response ◽  
Cd8 T Cell ◽  
T Cell Response

278 AUGMENTED HEPATITIS B SPECIFIC T CELL RESPONSE AFTER CLEARANCE OF CHRONIC HEPATITIS B

2011 ◽  
Vol 54 ◽  
pp. S114 ◽  
Author(s):  
A. de Niet ◽  
M.J. Tempelmans Plat-Sinnige ◽  
R.B. Takkenberg ◽  
H.W. Reesink ◽  
R.A.W. van Lier ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
T Cell ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Cell Response ◽  
T Cell Response

Hepatitis B virus-specific T cell response in chronic hepatitis B patients treated with lamivudine and interferon-alpha

2004 ◽  
Vol 24 (4) ◽  
pp. 308-315 ◽  
Author(s):  
Oscar Pontesilli ◽  
Andeltje B. van Nunen ◽  
Debby van Riel ◽  
Patrizia Carotenuto ◽  
Hubert G. Niesters ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B Virus ◽  
T Cell ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Interferon Alpha ◽  
Cell Response ◽  
T Cell Response ◽  
B Virus

scholarly journals An immunodominant HLA-A*1101-restricted CD8+ T-cell response targeting hepatitis B surface antigen in chronic hepatitis B patients

2013 ◽  
Vol 94 (12) ◽  
pp. 2717-2723 ◽  
Author(s):  
Xiaoling Chen ◽  
Wenbo Wang ◽  
Shufeng Wang ◽  
Gang Meng ◽  
Mengjun Zhang ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
T Cell ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Surface Antigen ◽  
Cell Response ◽  
Hepatitis B Surface Antigen ◽  
T Cell Response ◽  
Hbv Infection ◽  
Healthy Individuals

Hepatitis B virus (HBV) infection is a worldwide public health problem. HBV-specific CD8+ CTLs are vital for viral clearance. Identification of immunodominant CTL epitopes from HBV-associated antigens is necessary for therapeutic vaccine development. We showed that the HLA-A*1101 allele is one of the most common alleles in both healthy individuals and chronic hepatitis B (CHB) patients in the Chongqing area, China. However, less than 10 % of epitopes of HBV-associated antigens have been identified in an HLA-A*1101 context. Here, we describe an immunodominant CD8+ T-cell response targeting a hepatitis B surface antigen determinant (HBs295–304) restricted by HLA-A*1101 in both healthy individuals and CHB patients. Moreover, HBs295–304 is more immunogenic for CTL induction than a known naturally HLA-A*1101-processed epitope from hepatitis B core antigen (HBc88–96). Therefore, the newly identified epitope, HBs295–304, will benefit the development of immunotherapeutic approaches for HBV infection.

scholarly journals The Size of the Viral Inoculum Contributes to the Outcome of Hepatitis B Virus Infection

2009 ◽  
Vol 83 (19) ◽  
pp. 9652-9662 ◽  
Author(s):  
Shinichi Asabe ◽  
Stefan F. Wieland ◽  
Pratip K. Chattopadhyay ◽  
Mario Roederer ◽  
Ronald E. Engle ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
T Cell ◽  
Hepatitis B ◽  
Cell Response ◽  
T Cell Response ◽  
Cd4 T Cell ◽  
Viral Spread ◽  
B Virus ◽  
T Cell Priming ◽  
Kinetics Of

ABSTRACT The impact of virus dose on the outcome of infection is poorly understood. In this study we show that, for hepatitis B virus (HBV), the size of the inoculum contributes to the kinetics of viral spread and immunological priming, which then determine the outcome of infection. Adult chimpanzees were infected with a serially diluted monoclonal HBV inoculum. Unexpectedly, despite vastly different viral kinetics, both high-dose inocula (1010 genome equivalents [GE] per animal) and low-dose inocula (10° GE per animal) primed the CD4 T-cell response after logarithmic spread was detectable, allowing infection of 100% of hepatocytes and requiring prolonged immunopathology before clearance occurred. In contrast, intermediate (107 and 104 GE) inocula primed the T-cell response before detectable logarithmic spread and were abruptly terminated with minimal immunopathology before 0.1% of hepatocytes were infected. Surprisingly, a dosage of 101 GE primed the T-cell response after all hepatocytes were infected and caused either prolonged or persistent infection with severe immunopathology. Finally, CD4 T-cell depletion before inoculation of a normally rapidly controlled inoculum precluded T-cell priming and caused persistent infection with minimal immunopathology. These results suggest that the relationship between the kinetics of viral spread and CD4 T-cell priming determines the outcome of HBV infection.

scholarly journals Hepatitis B virus-specific CD4 T cell immunity after liver transplantation for chronic hepatitis B

2009 ◽  
Vol 15 (3) ◽  
pp. 292-299 ◽  
Author(s):  
Ying Luo ◽  
Chung Mau Lo ◽  
Cindy K. Cheung ◽  
George K. Lau ◽  
John Wong
Keyword(s):  
Liver Transplantation ◽  
Chronic Hepatitis ◽  
Hepatitis B Virus ◽  
T Cell ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
T Cell Immunity ◽  
Cd4 T Cell ◽  
Cell Immunity ◽  
B Virus
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