Clinicopathological significance of ‘subtypes with stem-cell feature’ in combined hepatocellular-cholangiocarcinoma

2014 ◽  
Vol 35 (3) ◽  
pp. 1024-1035 ◽  
Author(s):  
Motoko Sasaki ◽  
Hirohide Sato ◽  
Yuko Kakuda ◽  
Yasunori Sato ◽  
Joon Hyuk Choi ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Feature ◽  
Clinicopathological Significance ◽  
Combined Hepatocellular Cholangiocarcinoma

Clinicopathological significance of cancer stem cell markers CD44 and ALDH1 expression in breast cancer

Breast Cancer ◽  
2018 ◽  
Vol 25 (6) ◽  
pp. 698-705 ◽  
Author(s):  
Tahani Louhichi ◽  
Sonia Ziadi ◽  
Hanene Saad ◽  
Myriam Ben Dhiab ◽  
Sarra Mestiri ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Stem Cell Markers ◽  
Cell Markers ◽  
Cancer Stem Cell Markers ◽  
Aldh1 Expression ◽  
Clinicopathological Significance

scholarly journals MP88-14 CANCER STEM CELL FEATURE CAN INDUCE RESISTANCE TO MTOR INHIBITORS VIA THE NOTCH PATHWAY IN RENAL CELL CARCINOMAS

2018 ◽  
Vol 199 (4S) ◽  
Author(s):  
Kazuyuki Numakura ◽  
Jesse Novac ◽  
Jean-Christophe Pignon ◽  
Toni Choueiri ◽  
Sabina Signoretti
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Renal Cell ◽  
Notch Pathway ◽  
Mtor Inhibitors ◽  
Renal Cell Carcinomas ◽  
Stem Cell Feature ◽  
Induce Resistance

scholarly journals Clinical features and diagnostic imaging of cholangiolocellular carcinoma compared with other primary liver cancers: a surgical perspective

2020 ◽  
Vol 19 ◽  
pp. 153303382094814
Author(s):  
Hiroyuki Takamura ◽  
Ryousuke Gabata ◽  
Yoshinao Obatake ◽  
Shinichi Nakanuma ◽  
Hironori Hayashi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Stem Cell ◽  
Diagnostic Imaging ◽  
Classical Type ◽  
Intermediate Type ◽  
Cholangiolocellular Carcinoma ◽  
Donor Liver Transplantation ◽  
Combined Hepatocellular And Cholangiocarcinoma ◽  
Liver Cancers ◽  
Stem Cell Feature

Background and Objectives: Although cholangiolocellular carcinoma is considered a combined hepatocellular and cholangiocarcinoma, we feel that this classification is not appropriate. Therefore, we compared the diagnostic imaging findings, surgical prognosis, and pathological features of cholangiolocellular carcinoma with those of other combined hepatocellular and cholangiocarcinoma subtypes, hepatocellular carcinoma, and cholangiocarcinoma. Methods: The study patients included 7 with classical type combined hepatocellular and cholangiocarcinoma; 8 with stem cell feature, intermediate type combined hepatocellular and cholangiocarcinoma; 13 with cholangiolocellular carcinoma; 58 with cholangiocarcinoma; and 359 with hepatocellular carcinoma. All patients underwent hepatectomy or living-related donor liver transplantation from 2001 to 2014. Results: cholangiolocellular carcinoma could be distinguished from hepatocellular carcinom, other combined hepatocellular and cholangiocarcinoma subtypes, and cholangiocarcinoma by the presence of intratumoral Glisson’s pedicle, hepatic vein penetration, and tumor-staining pattern on angiography-assisted CT. Cholangiolocellular carcinoma was associated with a significantly lower SUV-max than that of cholangiocarcinoma on FDG-PET. Hepatocellular carcinoma, classical type, and cholangiolocellular carcinoma had significantly better prognoses than stem cell feature, intermediate type and cholangiocarcinoma. A cholangiocarcinoma component was detected in cholangiolocellular carcinoma that progressed to the hepatic hilum, and the cholangiocarcinoma component was found in perineural invasion and lymph node metastases. Conclusions: From the viewpoint of surgeon, cholangiolocellular carcinoma should be classified as a good-prognosis subtype of biliary tract carcinoma because of its tendency to differentiate into cholangiocarcinoma during its progression, and its distinctive imaging and few recurrence rates different from other combined hepatocellular and cholangiocarcinoma subtypes.

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