SATB1 expression and its association with tumour prognosis in systemic malignancies: an evolving concept in oncology

2012 ◽  
Vol 33 (2) ◽  
pp. 322-322 ◽  
Author(s):  
Shailendra Kapoor
Keyword(s):  
Satb1 Expression ◽  
Tumour Prognosis

SATB1 Expression Governs Follicular Helper T-cell-Triggered Tertiary Lymphoid Structure Assembly

2021 ◽  
Author(s):  
Ricardo A. Chaurio ◽  
Carmen M. Anadon ◽  
Tara L. Costich ◽  
Kyle K. Payne ◽  
Subir Biswas ◽  
...  
Keyword(s):  
T Cell ◽  
Helper T Cell ◽  
Follicular Helper ◽  
Follicular Helper T Cell ◽  
Satb1 Expression ◽  
Structure Assembly

Esthesioneuroblastoma

2019 ◽  
pp. 205-212
Author(s):  
Georgios Klironomos ◽  
Lior Gonen ◽  
Fred Gentili
Keyword(s):  
Olfactory Mucosa ◽  
Malignant Tumours ◽  
Craniofacial Resection ◽  
Regional Lymph Nodes ◽  
Endoscopic Techniques ◽  
Therapeutic Modalities ◽  
Staging Systems ◽  
High Index Of Suspicion ◽  
Tumour Prognosis

Esthesioneuroblastomas (ENB) are rare malignant tumours of neuroepithelial origin arising from the olfactory mucosa. Not uncommonly they metastasize to regional lymph nodes and distant organs. Commonly they have a long and insidious course and the diagnosis requires a high index of suspicion. Since this tumour was first described, many grading and staging systems have been proposed but still there is some controversy on which correlates best with tumour prognosis. The classic treatment for ENB is craniofacial resection with the goal of gross total resection and achievement of tumour-free margins. The enormous advances in endoscopic techniques over the last two decades means this now has comparable results in achieving tumour-free margins, especially for low stage tumours. The role of preoperative and postoperative radiation has been well established in the treatment of this tumour. Controversy exists regarding the role of neck dissection or elective neck radiation as standard therapeutic modalities.

SATB1 Expression of Colorectal Adenomatous Polyps is Higher than that of Colorectal Carcinomas

2019 ◽  
Vol 28 (7) ◽  
pp. 532-537
Author(s):  
Gulsum S. Yalcin ◽  
Mehmet A. Gonultas ◽  
Sema Hucumenoglu ◽  
Gulcin Simsek ◽  
Mevlut R. Pekcici
Keyword(s):  
Adenomatous Polyps ◽  
Colorectal Carcinomas ◽  
Satb1 Expression

scholarly journals Decreased SATB1 expression promotes AML cell proliferation through NF-κB activation

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Xiaodan Luo ◽  
Lihua Xu ◽  
Xiaohong Wu ◽  
Huo Tan ◽  
Lian Liu
Keyword(s):  
Cell Proliferation ◽  
Satb1 Expression

SNF5 deficiency induces apoptosis resistance by repressing SATB1 expression in Sézary syndrome

2018 ◽  
Vol 59 (10) ◽  
pp. 2405-2413 ◽  
Author(s):  
Yang Li ◽  
Jin Wang ◽  
Minghang Yu ◽  
Yang Wang ◽  
Huilai Zhang ◽  
...  
Keyword(s):  
Sézary Syndrome ◽  
Sezary Syndrome ◽  
Apoptosis Resistance ◽  
Satb1 Expression

scholarly journals HER2, NF-κB, and SATB1 Expression Patterns in Gastric Cancer and Their Correlation with Clinical and Pathological Parameters

2019 ◽  
Vol 2019 ◽  
pp. 1-14 ◽  
Author(s):  
Marta Smolińska ◽  
Dariusz Grzanka ◽  
Paulina Antosik ◽  
Anna Kasperska ◽  
Izabela Neska-Długosz ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Progression ◽  
Statistical Significance ◽  
Expression Patterns ◽  
Clinical Information ◽  
Tissue Microarrays ◽  
Gastric Cancer Tissue ◽  
Cancer Tissue ◽  
Satb1 Expression

Gastric cancer (GC) is currently recognized as one of the most common and fatal tumor worldwide. The identification of novel biomarkers in relation to clinical information as well as extending the knowledge on a multiple crosstalk between various oncogenic pathways implicated in GC carcinogenesis seems pivotal to limit the disease-associated mortality. Therefore, we assessed the expression of HER2, NF-κB, and SATB1 in a total of 104 gastric adenocarcinomas and 30 normal gastric samples and correlated the expression patterns with each other and with some clinicopathological variables. Protein expression was examined by immunohistochemistry (IHC) on tissue microarrays (TMAs), and fluorescence in situ hybridization (FISH) was employed to detect HER2 amplification. In the studied group, HER2 and SATB1 were found to be overexpressed in gastric cancer tissue in comparison to normal gastric mucosa. The expression status of the former protein was seen to differ according to some clinicopathological features, but without statistical significance, whereas the expression of the latter was not importantly associated with any of them. In turn, the NF-κB protein level was significantly related to the presence of lymph node metastasis. HER2 expression was not significantly correlated with that of other proteins, but a positive correlation was found between the expression of SATB1 and NF-κB. Further studies with a larger group of patients combined with in vitro mechanistic experiments are required to fully elucidate the role and relationship of HER2, NF-κB, and SATB1 expression in gastric cancer progression. However, to the best of our knowledge, this study is the first look at a simultaneous evaluation of these three markers in the samples of gastric cancer patients.

scholarly journals The Role of SATB1 in Tumour Progression and Metastasis

2019 ◽  
Vol 20 (17) ◽  
pp. 4156 ◽  
Author(s):  
Glatzel-Plucińska ◽  
Piotrowska ◽  
Dzięgiel ◽  
Podhorska-Okołów
Keyword(s):  
Cancer Progression ◽  
Poor Prognosis ◽  
Tumour Progression ◽  
Prognostic Significance ◽  
Distant Metastases ◽  
Mesenchymal Transition ◽  
Epithelial Cancers ◽  
Multistep Process ◽  
Satb1 Expression

Carcinogenesis is a long-drawn, multistep process, in which metastatic spread is an unequivocal hallmark of a poor prognosis. The progression and dissemination of epithelial cancers is commonly thought to rely on the epidermal-mesenchymal transition (EMT) process. During EMT, epithelial cells lose their junctions and apical-basal polarity, and they acquire a mesenchymal phenotype with its migratory and invasive capabilities. One of the proteins involved in cancer progression and EMT may be SATB1 (Special AT-Rich Binding Protein 1)—a chromatin organiser and a global transcriptional regulator. SATB1 organizes chromatin into spatial loops, providing a “docking site” necessary for the binding of further transcription factors and chromatin modifying enzymes. SATB1 has the ability to regulate whole sets of genes, even those located on distant chromosomes. SATB1 was found to be overexpressed in numerous malignancies, including lymphomas, breast, colorectal, prostate, liver, bladder and ovarian cancers. In the solid tumours, an elevated SATB1 level was observed to be associated with an aggressive phenotype, presence of lymph node, distant metastases, and a poor prognosis. In this review, we briefly describe the prognostic significance of SATB1 expression in most common human cancers, and analyse its impact on EMT and metastasis.

scholarly journals SATB1 Expression Governs Epigenetic Repression of PD-1 in Tumor-Reactive T Cells

Immunity ◽  
2017 ◽  
Vol 46 (1) ◽  
pp. 51-64 ◽  
Author(s):  
Tom L. Stephen ◽  
Kyle K. Payne ◽  
Ricardo A. Chaurio ◽  
Michael J. Allegrezza ◽  
Hengrui Zhu ◽  
...  
Keyword(s):  
T Cells ◽  
Satb1 Expression ◽  
Epigenetic Repression
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