scholarly journals Probiotic survival during a multi‐layered tablet development as tested in a dynamic, computer‐controlled in vitro model of the stomach and small intestine (TIM‐1)

2019 ◽  
Vol 69 (5) ◽  
pp. 325-332 ◽  
Author(s):  
K. Venema ◽  
J. Verhoeven ◽  
S. Verbruggen ◽  
L. Espinosa ◽  
S. Courau
Keyword(s):  
Small Intestine ◽  
In Vitro Model ◽  
Computer Controlled ◽  
Vitro Model

scholarly journals Silicon dioxide nanoparticle exposure affects small intestine function in an in vitro model

2018 ◽  
Vol 12 (5) ◽  
pp. 485-508 ◽  
Author(s):  
Zhongyuan Guo ◽  
Nicole J. Martucci ◽  
Yizhong Liu ◽  
Eusoo Yoo ◽  
Elad Tako ◽  
...  
Keyword(s):  
Small Intestine ◽  
Silicon Dioxide ◽  
In Vitro Model ◽  
Nanoparticle Exposure ◽  
Vitro Model ◽  
Silicon Dioxide Nanoparticle

Differentiated CaCo-2 cells as an in-vitro model to evaluate de-novo apolipoprotein A-I production in the small intestine

2009 ◽  
Vol 21 (6) ◽  
pp. 642-649 ◽  
Author(s):  
Stefan P.J. Dullens ◽  
Ronald P. Mensink ◽  
Edwin C.M. Mariman ◽  
Jogchum Plat
Keyword(s):  
Small Intestine ◽  
In Vitro Model ◽  
De Novo ◽  
Apolipoprotein A ◽  
Vitro Model

scholarly journals Xylo-oligosaccharides from sugarcane show prebiotic potential in a dynamic computer-controlled in vitro model of the adult human large intestine

2020 ◽  
Vol 11 (2) ◽  
pp. 191-200 ◽  
Author(s):  
K. Venema ◽  
J. Verhoeven ◽  
S. Verbruggen ◽  
D. Keller
Keyword(s):  
In Vitro Model ◽  
Short Chain Fatty Acids ◽  
Rrna Gene ◽  
Microbiota Composition ◽  
Gut Health ◽  
Unidentified Species ◽  
Human Adults ◽  
Computer Controlled ◽  
Vitro Model

The aim of the study was to investigate the prebiotic potential of xylo-oligosaccharides (XOS) from sugarcane in a validated, dynamic, computer-controlled in vitro model of the colon (TIM-2) simulating human adults. In two sets of experiments, each with a different microbiota, 3 different doses of XOS were tested at 1.0 g/day, 1.5 g/day and 3.0 g/day. The in vitro model was run for 72 h, and at the start and subsequently every 24 h samples were taken and analysed for short-chain fatty acids (SCFA) and gut microbiota composition. SCFA were analysed using ion chromatography, whereas microbiota composition was analysed using sequencing of the V3-V4 region of the 16S rRNA gene. XOS showed a similar SCFA production per gram of substrate as the control medium, including butyrate, which is considered to be important for gut health. In both sets of experiments XOS showed a consistent dose-dependent increase in abundance over time of the genus Bifidobacterium, and within that of the species B. adolescentis and an unidentified species (labelled ‘sp.1’). The results show the potential prebiotic effect of XOS from sugarcane, by its capacity to generate butyrate and increase the health-beneficial bifidobacteria.

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