scholarly journals Synergistic effect of nikkomycin Z with caspofungin and micafungin against Candida albicans and Candida parapsilosis biofilms

2019 ◽  
Vol 69 (4) ◽  
pp. 271-278 ◽  
Author(s):  
R. Kovács ◽  
F. Nagy ◽  
Z. Tóth ◽  
A. Bozó ◽  
B. Balázs ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Synergistic Effect ◽  
Candida Parapsilosis ◽  
Nikkomycin Z

scholarly journals Synergistic Effect of Plant Extracts on Endodontic Pathogens Isolated from Teeth with Root Canal Treatment Failure: An In Vitro Study

Antibiotics ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 552
Author(s):  
Suraj Arora ◽  
Shahabe Saquib ◽  
Youssef Algarni ◽  
Mohammed Kader ◽  
Irfan Ahmad ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Candida Albicans ◽  
Synergistic Effect ◽  
Enterococcus Faecalis ◽  
Plant Extracts ◽  
Azadirachta Indica ◽  
Inhibitory Concentration ◽  
Pathogenic Microorganisms ◽  
Salvadora Persica ◽  
Actinomyces Naeslundii

Background and objectives: This study aimed to evaluate the synergistic antimicrobial activity of extracts obtained from Salvadora persica (Miswak), Commiphora molmol (myrrh) and Azadirachta indica (neem) in combination with commercially available antimicrobial agents: penicillin, tetracycline, ofloxacin and fluconazole on endodontic pathogens such as Enterococcus faecalis, Streptococcus mitis, Actinomyces naeslundii and Candida albicans. Materials and Methods: Microbiological samples from the root canals of the teeth undergoing retreatment were taken using sterile paper points kept at full length in the canal for 30 seconds. The disc diffusion method was used to check the susceptibility of microbes to the plant extracts and antimicrobials by measuring the diameter of the inhibition zones. Against the microbes, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC)/minimum fungicidal concentration (MFC) of the plant extracts were assessed. The fractional inhibitory concentration index (FICI) was used to estimate the synergistic effect of plant extracts combined with antimicrobials against the resistant endodontic microbes. Results: The findings clearly indicate the effectiveness of all the three plant extracts, Commiphora molmol, Azadirachta indica, Salvadora persica, against all the experimental pathogenic microorganisms except for the ineffectiveness of Azadirachta indica, Salvadora persica against Candida albicans. Maximum antimicrobial activity was displayed by Azadirachta indica against Enterococcus faecalis (MIC = 0.09 ± 1.2 mg/mL, MBC = 0.78 ± 1.25 mg/mL) and the minimum antimicrobial activity was displayed by Commiphora molmol against Actinomyces naeslundii (MIC = 12.5 ± 3.25 mg/mL, MBC = 100 ± 3.75 mg/mL). The best synergy was displayed by Commiphora molmol with fluconazole against Candida albicans (FICI = 0.45). Conclusions: The current study delineates the variable antimicrobial activity of plant extracts against the experimental endodontic pathogenic microorganisms. Plant extracts in conjunction with various antimicrobials can be valuable aids in combating relatively resistant endodontic microorganisms that have been the cause of worry in recent years, leading to failure even in treatment procedures following all required protocols.

scholarly journals Infecções oportunistas por leveduras e perfil enzimático dos agentes etiológicos

2009 ◽  
Vol 42 (2) ◽  
pp. 188-191 ◽  
Author(s):  
Danielle Patrícia Cerqueira Macêdo ◽  
Aline Mary de Almeida Farias ◽  
Reginaldo Gonçalves de Lima Neto ◽  
Vanessa Karina Alves da Silva ◽  
André Ferraz Goiana Leal ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Candida Tropicalis ◽  
Candida Parapsilosis ◽  
Candida Guilliermondii ◽  
Candida Krusei

Infecções por leveduras são freqüentes em imunocomprometidos, contudo espécies emergentes têm alterado o perfil epidemiológico. A habilidade de secretar proteases tem sido associada à patogenicidade do gênero Candida. Esta pesquisa teve como objetivos diagnosticar leveduroses em pacientes imunocomprometidos e avaliar a virulência dos agentes etiológicos baseado em teste de secreção de protease utilizando soro de albumina bovina como substrato. Do total de 104 pacientes estudados, 19 apresentaram episódios de leveduroses. O trato respiratório (63,2%), seguido pelo trato urinário (10,5%) foram os locais mais comuns de infecção. Candida albicans, Candida parapsilosis, Candida tropicalis e espécies emergentes como Candida krusei e Candida guilliermondii foram isoladas. Cinco isolados de Candida parapsilosis e um de Candida albicans e Candida guilliermondii exibiram alta atividade enzimática. Concluímos que a caracterização enzimática de isolados de Candida pode ser um útil marcador prognóstico, especialmente em imunocomprometidos, uma vez que leveduroses nestes pacientes são geralmente graves.

scholarly journals Differential Activities of Newer Antifungal Agents against Candida albicans and Candida parapsilosis Biofilms

2007 ◽  
Vol 52 (1) ◽  
pp. 357-360 ◽  
Author(s):  
Αspasia Katragkou ◽  
Athanasios Chatzimoschou ◽  
Maria Simitsopoulou ◽  
Maria Dalakiouridou ◽  
Eudoxia Diza-Mataftsi ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Antifungal Agents ◽  
Candida Parapsilosis ◽  
Planktonic Cells

ABSTRACT The activities of voriconazole, posaconazole, caspofungin, and anidulafungin against Candida albicans and Candida parapsilosis biofilms were evaluated. In contrast to planktonic cells, the MICs for voriconazole and posaconazole for the biofilms of the two species were high (≥256 and >64 mg/liter, respectively) but relatively low for the echinocandins caspofungin and anidulafungin (≤1 and ≤2 mg/liter, respectively).

scholarly journals Conserved and Divergent Roles of Bcr1 and CFEM Proteins in Candida parapsilosis and Candida albicans

PLoS ONE ◽  
2011 ◽  
Vol 6 (12) ◽  
pp. e28151 ◽  
Author(s):  
Chen Ding ◽  
Genevieve M. Vidanes ◽  
Sarah L. Maguire ◽  
Alessandro Guida ◽  
John M. Synnott ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Candida Parapsilosis

scholarly journals INCIDENCES OF CANDIDA ALBICANS AND NON-ALBICANS AMONG CATHETER-ASSOCIATED URINARY TRACT INFECTION PATIENTS OF AKOLA CITY

2017 ◽  
Vol 10 (11) ◽  
pp. 115
Author(s):  
Khandare Ln ◽  
Barate Dl
Keyword(s):  
Urinary Tract Infection ◽  
Candida Albicans ◽  
Urinary Tract ◽  
Tract Infection ◽  
Candida Parapsilosis ◽  
Opportunistic Infections ◽  
Urine Samples ◽  
Age Group ◽  
Candida Spp ◽  
Catheter Urine

Objective: Candida spp. is the third leading cause of catheter-related infections. Candida species is a part of human microflora and it becomes pathogenic when certain conditions are present and cause an opportunistic infections. The present study was undertaken to determine incidences of Candida albicans and non-albicans among catheterized urinary tract infection (UTI) patients of Akola city.Methods: A total 60 catheter urine samples were collected from patient of all the age group and both sex who had indwelling urinary catheter. The collected catheterized urine samples of patients from various hospitals of Akola city were used for isolation using HiCrome Candida differential agar.Results: It was found that highest frequency of isolation of Candida spp. was from age group 61-70 years. The predominance of male candidate was more than female having Candida spp. in catheter-associated UTI (C-UTI). Among the Candida spp. C. albicans (64.81%) was predominant over non-albicans spp. while in non-albicans Candida krusei and Candida glabrata were predominant showing 11.11% incidences. It was followed by Candida tropicalis (9.2%) and Candida parapsilosis (3.7%).Conclusion: The incidences of C. albicans and non-albicans were high among catheter-associated UTI patients.

scholarly journals EFFECT OF MUCUNA COCHINCHINENSIS EXTRACTS ON EFFLUX PUMP IN FUNGAL STRAINS

2020 ◽  
pp. 94-96
Author(s):  
NATARAJAN K. ◽  
KUMARESH JAWAHAR N.
Keyword(s):  
Experimental Data ◽  
Candida Albicans ◽  
Aspergillus Niger ◽  
Synergistic Effect ◽  
Efflux Pump ◽  
Methanolic Extract ◽  
Ethanolic Extract ◽  
Inhibition Activity ◽  
Fungal Strains ◽  
Efflux Pump Inhibition

Objective: To study the efflux pump inhibition activity of Mucunacochinchinensis extracts Methods: Sensitivity assay was performed by Kirby Bauer technique. Effluxing ability of microbe was done by accretion, accumulation and efflux pump assays. Results: Resistant fungal strains were subjected to efflux ability studies. Maximum effluxing ability was determined from the experimental data and it was found to be 105 min and 75 min by Candida albicans for methanolic extract of M. cochinchinenesis (MMC) and ethanolic extract of M. cochinchinensis (EMC) respectively and 45 min and 105 min by Aspergillus niger for MMC and EMC respectively. Profound synergistic effect of inhibition was observed with combined MMC and standard Clotrimoxazole when compared to the standard alone; against C. albicansindicates the modulating efficacy of MMC. Conclusion: M. cochinchinensis extracts showed efflux pump modulating activity.

scholarly journals Synergistic Activity of Chloroquine with Fluconazole against Fluconazole-Resistant Isolates of Candida Species

2014 ◽  
Vol 59 (2) ◽  
pp. 1365-1369 ◽  
Author(s):  
Yali Li ◽  
Zhe Wan ◽  
Wei Liu ◽  
Ruoyu Li
Keyword(s):  
Candida Albicans ◽  
Synergistic Effect ◽  
Candida Tropicalis ◽  
Candida Krusei ◽  
Synergistic Activity ◽  
Broth Microdilution ◽  
Content Type ◽  
Fluconazole Resistant ◽  
Susceptibility Tests

ABSTRACTThein vitroactivity of chloroquine and the interactions of chloroquine combined with fluconazole against 37Candidaisolates were tested using the broth microdilution, disk diffusion, and Etest susceptibility tests. Synergistic effect was detected with 6 of 9 fluconazole-resistantCandida albicansisolates, withCandida kruseiATCC 6258, and with all 12 fluconazole-resistantCandida tropicalisisolates.

Extracellular Aspartic Proteinases from Candida albicans, Candida tropicalis, and Candida parapsilosis Yeasts Differ Substantially in Their Specificities

Biochemistry ◽  
1994 ◽  
Vol 33 (32) ◽  
pp. 9791-9799 ◽  
Author(s):  
Martin Fusek ◽  
Elizabeth A. Smith ◽  
Michael Monod ◽  
Ben M. Dunn ◽  
Stephen I. Foundling
Keyword(s):  
Candida Albicans ◽  
Candida Tropicalis ◽  
Candida Parapsilosis ◽  
Aspartic Proteinases
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