scholarly journals Oral administration ofLactobacillus brevisKB290 to mice alleviates clinical symptoms following influenza virus infection

2013 ◽  
Vol 58 (1) ◽  
pp. 87-93 ◽  
Author(s):  
N. Waki ◽  
N. Yajima ◽  
H. Suganuma ◽  
B.M. Buddle ◽  
D. Luo ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Oral Administration ◽  
Clinical Symptoms ◽  
Influenza Virus Infection

scholarly journals Protection against Influenza Virus Infection of Mice Fed Bifidobacterium breve YIT4064

1999 ◽  
Vol 6 (2) ◽  
pp. 186-192 ◽  
Author(s):  
Hisako Yasui ◽  
Junko Kiyoshima ◽  
Tetuji Hori ◽  
Kan Shida
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Oral Administration ◽  
Lower Respiratory Tract ◽  
Influenza Virus Infection ◽  
Oral Immunization ◽  
Igg Antibodies ◽  
Virus Infections ◽  
Bifidobacterium Breve ◽  
Specific Igg

ABSTRACT Mice fed Bifidobacterium breve YIT4064 and immunized orally with influenza virus were more strongly protected against influenza virus infection of the lower respiratory tract than ones immunized with influenza virus only. The number of mice with enhanced anti-influenza virus immunoglobulin G (IgG) in serum upon oral administration of B. breve YIT4064 and oral immunization with influenza virus was significantly greater than that upon oral immunization with influenza virus only. These findings demonstrated that the oral administration of B. breve YIT4064 increased anti-influenza virus IgG antibodies in serum and protected against influenza virus infection. The oral administration of B. breve YIT4064 may enhance antigen-specific IgG against various pathogenic antigens taken orally and induce protection against various virus infections.

Oral administration of heat-killed Lactobacillus pentosus strain b240 augments protection against influenza virus infection in mice

2011 ◽  
Vol 11 (2) ◽  
pp. 199-203 ◽  
Author(s):  
Noritada Kobayashi ◽  
Takao Saito ◽  
Takayuki Uematsu ◽  
Kazumasa Kishi ◽  
Masamichi Toba ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Oral Administration ◽  
Influenza Virus Infection ◽  
Lactobacillus Pentosus

scholarly journals Akkermansia muciniphila Improves Host Defense Against Influenza Virus Infection

2021 ◽  
Vol 11 ◽  
Author(s):  
Xiaotong Hu ◽  
Ya Zhao ◽  
Yong Yang ◽  
Wenxiao Gong ◽  
Xiaomei Sun ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Gut Microbiota ◽  
Oral Administration ◽  
Current Knowledge ◽  
Influenza Virus Infection ◽  
Akkermansia Muciniphila ◽  
Reduce Weight Loss ◽  
H7n9 Infection

Influenza virus infection can alter the composition of the gut microbiota, while its pathogenicity can, in turn, be highly influenced by the gut microbiota. However, the details underlying these associations remain to be determined. The H7N9 influenza virus is an emerging zoonotic pathogen which has caused the death of 616 humans and has incurred huge losses in the poultry industry. Here, we investigated the effects of infection with highly pathogenic H7N9 on gut microbiota and determined potential anti-influenza microbes. 16S rRNA sequencing results show that H7N9 infection alters the mouse gut microbiota by promoting the growth of Akkermansia, Ruminococcus 1, and Ruminococcaceae UCG-010, and reducing the abundance of Rikenellaceae RC9 gut group and Lachnoclostridium. Although the abundance of Akkermansia muciniphila is positively related to H7N9 infection, the oral administration of cultures, especially of pasteurized A. muciniphila, can significantly reduce weight loss and mortality caused by H7N9 infection in mice. Furthermore, oral administration of live or pasteurized A. muciniphila significantly reduces pulmonary viral titers and the levels IL-1β and IL-6 but enhances the levels of IFN-β, IFN-γ, and IL-10 in H7N9-infected mice, suggesting that the anti-influenza role of A. muciniphila is due to its anti-inflammatory and immunoregulatory properties. Taken together, we showed that the changes in the gut microbiota are associated with H7N9 infection and demonstrated the anti-influenza role of A. muciniphila, which enriches current knowledge about how specific gut bacterial strains protect against influenza infection and suggests a potential anti-influenza probiotic.

scholarly journals Oral Administration of Lactobacillus plantarum Strain AYA Enhances IgA Secretion and Provides Survival Protection against Influenza Virus Infection in Mice

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e86416 ◽  
Author(s):  
Yosuke Kikuchi ◽  
Ayami Kunitoh-Asari ◽  
Katsuyuki Hayakawa ◽  
Shinjiro Imai ◽  
Kenji Kasuya ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Oral Administration ◽  
Lactobacillus Plantarum ◽  
Influenza Virus Infection

scholarly journals Anti-influenza virus effects of both live and non-live Lactobacillus acidophilus L-92 accompanied by the activation of innate immunity

2013 ◽  
Vol 110 (10) ◽  
pp. 1810-1818 ◽  
Author(s):  
Hiroaki Goto ◽  
Atsuhiro Sagitani ◽  
Nobuhisa Ashida ◽  
Shinji Kato ◽  
Tatsuhiko Hirota ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Oral Administration ◽  
Lactobacillus Acidophilus ◽  
Influenza Virus Infection ◽  
Mechanistic Study ◽  
Control Group ◽  
Interferon Α ◽  
Nk Activity ◽  
Cytokines And Chemokines

The antiviral effects of both a live and non-live Lactobacillus acidophilus strain L-92 (L-92) were investigated by oral administration (10 mg/mouse per d) daily for 21 d in a mouse model infected intranasally with influenza virus (H1N1). Virus titres in the lung of mice administered either live or non-live L-92 cells daily for 15 d were repressed 6 d after virus infection compared with the control group. Natural killer (NK) activity in the orally administered non-live L-92 group was higher compared with that of the control group before virus infection and on day 6. In contrast, NK activity in the live L-92 group compared with the control group was not significantly changed on both days, but was significantly higher on day 1. In contrast, live L-92 showed a greater repression of virus proliferation compared with non-live L-92, 6 d after the infection. Live L-92 decreased the number of neutrophils in the lung and suppressed lung weight, leading to the consequent deterioration of consolidation scores of the lung. These results indicated that pretreatment of live or non-live L-92 cells had protective effects against influenza virus infection. Among the measured cytokines and chemokines, eotaxin, macrophage colony-stimulating factor, IL-1β, RANTES (regulated on activation, normal T cell expressed and secreted) and interferon-α were significantly increased in the lung: IL-17 was significantly increased in Peyer's patch of the live L-92 group compared with the control group. A mechanistic study suggested that the enhancement of NK activity in the lung caused by stimulating various antiviral cytokines and chemokines after the oral administration of L-92 cells might be important in protecting against virus infection.

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