Pharmacokinetic profile of a single dose of an oral pradofloxacin suspension administered to eastern long‐necked turtles ( Chelodina longicollis )

2020 ◽  
Author(s):  
Emily Taylor ◽  
Darren J. Trott ◽  
Benjamin Kimble ◽  
Shangzhe Xie ◽  
Merran Govendir ◽  
...  
Keyword(s):  
Single Dose ◽  
Pharmacokinetic Profile ◽  
Chelodina Longicollis

scholarly journals Pharmacokinetic profile and metabolite identification of bornyl caffeate and caffeic acid in rats by high performance liquid chromatography coupled with mass spectrometry

RSC Advances ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. 4015-4027 ◽  
Author(s):  
Baimei Shi ◽  
Lingjian Yang ◽  
Tian Gao ◽  
Cuicui Ma ◽  
Qiannan Li ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Single Dose ◽  
Metabolic Profile ◽  
High Performance ◽  
Ion Trap ◽  
Metabolite Identification ◽  
Pharmacokinetic Profile ◽  
Tof Ms

We revealed the metabolic profile of bornyl caffeate by HPLC-Q-TOF/MS, and then simultaneously examined the pharmacokinetics of bornyl caffeate and CA after administration of a single dose of bornyl caffeate by HPLC ion trap MS.

scholarly journals Maternal-Fetal Pharmacokinetics and Dynamics of a Single Intrapartum Dose of Maraviroc in Rhesus Macaques

2010 ◽  
Vol 54 (10) ◽  
pp. 4059-4063 ◽  
Author(s):  
Mark A. Winters ◽  
Koen K. A. Van Rompay ◽  
Angela D. M. Kashuba ◽  
Nancy S. Shulman ◽  
Mark Holodniy
Keyword(s):  
Single Dose ◽  
Rhesus Macaques ◽  
Subsequent Development ◽  
Receptor Occupancy ◽  
Pharmacokinetic Profile ◽  
Maternal Plasma ◽  
Maximum Plasma ◽  
Time Curve ◽  
Ccr5 Receptor ◽  
Single Dose Nevirapine

ABSTRACT Single-dose nevirapine (NVP) is effective in reducing mother-to-child transmission (MTCT) of HIV; however, the subsequent development of drug resistance is problematic. The pharmacokinetic profile of the HIV entry inhibitor maraviroc after a single intrapartum dose in rhesus macaques was studied to determine whether maraviroc could serve as an alternative to NVP in a single-dose strategy. Four pregnant macaques received an oral dose of maraviroc 2 h before delivery, and both infant and maternal plasma maraviroc concentrations and CCR5 receptor occupancy on CD4+ lymphocytes were measured over time. Maximum plasma maraviroc concentrations were found at delivery (2-h-postintrapartum dose) in both the mothers and infants, with median concentrations of 974 ng/ml (range, 86 to 2,830 ng/ml) and 22 ng/ml (range, 4 to 99 ng/ml), respectively. Maraviroc was detected in the plasma of mothers up to 48 h after dosing but only as long as 3.5 h in the infants. The median fetal-maternal area under the concentration-time curve (AUC) ratio was 0.009 (range, 0.000 to 0.015). Maraviroc receptor occupancy data showed evidence of unprotected CCR5 receptors on CD4+ cells in the mothers 24 to 48 h after dosing. Extremely low CCR5 expression on CD4+ cells of newborn macaques prevented determination of receptor occupancy in the infants. In rhesus macaques, maraviroc was poorly transferred across the placenta and was quickly cleared from the infants’ blood. The low concentrations of fetal maraviroc and short pharmacokinetic profile in infants suggest that a single maternal intrapartum dose of maraviroc would not be effective in reducing the risk of MTCT of HIV.

Pharmacokinetic profile of propofol after a single-dose injection during general anesthesia in Japanese adults

2000 ◽  
Vol 14 (3) ◽  
pp. 124-127 ◽  
Author(s):  
Yoshinori Okada ◽  
Masashi Kawamoto ◽  
Kohyu Fujii ◽  
Osafumi Yuge
Keyword(s):  
Single Dose ◽  
General Anesthesia ◽  
Pharmacokinetic Profile ◽  
Japanese Adults ◽  
Dose Injection

Single Dose Oral Pharmacokinetic Profile of α-Mangostin in Mice

2012 ◽  
Vol 13 (14) ◽  
pp. 1698-1704 ◽  
Author(s):  
Atulkumar Ramaiya ◽  
Gongbo Li ◽  
Sakina M. Petiwala ◽  
Jeremy J. Johnson
Keyword(s):  
Single Dose ◽  
Pharmacokinetic Profile ◽  
Dose Oral

The single dose pharmacokinetic profile of a novel oral human parathyroid hormone formulation in healthy postmenopausal women

Bone ◽  
2012 ◽  
Vol 50 (4) ◽  
pp. 965-973 ◽  
Author(s):  
Sibylle P. Hämmerle ◽  
Linda Mindeholm ◽  
Aino Launonen ◽  
Beate Kiese ◽  
Rolf Loeffler ◽  
...  
Keyword(s):  
Single Dose ◽  
Parathyroid Hormone ◽  
Postmenopausal Women ◽  
Pharmacokinetic Profile ◽  
Human Parathyroid Hormone
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