scholarly journals Identification and characterization of the enzymes responsible for the metabolism of the non‐steroidal anti‐inflammatory drugs, flunixin meglumine and phenylbutazone, in horses

2020 ◽  
Author(s):  
Heather K. Knych ◽  
Carrie J. Finno ◽  
Russell Baden ◽  
Rick M. Arthur ◽  
Daniel S. McKemie
Keyword(s):  
Flunixin Meglumine ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Identification And Characterization

scholarly journals NSAID Gastroenteropathy: Past, Present and Future

1996 ◽  
Vol 10 (7) ◽  
pp. 451-459 ◽  
Author(s):  
John L Wallace
Keyword(s):  
Gastrointestinal Tract ◽  
Inflammatory Disorders ◽  
The Past ◽  
Prostaglandin Synthase ◽  
Nsaid Enteropathy ◽  
The Future ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Identification And Characterization

The toxicity of nonsteroidal anti-inflammatory drugs (NSAIDs) in the gastrointestinal tract continues to be a major limitation to their use in the treatment of inflammatory disorders. Better understanding of the pathogenesis of NSAID enteropathy has facilitated the development of novel NSAIDs that spare the gastrointestinal tract. In particular, identification and characterization of the inducible form of prostaglandin synthase has led to the design of novel NSAIDs that specifically target that enzyme. The pathogenesis of NSAID gastroenteropathy is reviewed, as are the strategies that have been used in the past and are used now to develop NSAIDs that spare the gastrointestinal tract. Also reviewed are the strategies being employed to achieve this goal in the future.

scholarly journals Characterization of subjects experiencing selective hypersensitivity reactions to non-steroidal anti-inflammatory drugs (NSAIDs)

2019 ◽  
Vol 143 (2) ◽  
pp. AB29
Author(s):  
Natalia Pérez-Sánchez ◽  
Inmaculada Doña ◽  
Maria Salas ◽  
Testera-Montes Almudena ◽  
Francisca Gomez ◽  
...  
Keyword(s):  
Hypersensitivity Reactions ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Marine Alkaloids with Anti-Inflammatory Activity: Current Knowledge and Future Perspectives

Marine Drugs ◽  
2020 ◽  
Vol 18 (3) ◽  
pp. 147 ◽  
Author(s):  
Cássio R. M. Souza ◽  
Wallace P. Bezerra ◽  
Janeusa T. Souto
Keyword(s):  
Current Knowledge ◽  
Biological Activities ◽  
Inflammatory Activity ◽  
Future Perspectives ◽  
Terrestrial Plants ◽  
Marine Alkaloids ◽  
Nitrogenous Compounds ◽  
Anti Inflammatory ◽  
Identification And Characterization

Alkaloids are nitrogenous compounds with various biological activities. Alkaloids with anti-inflammatory activity are commonly found in terrestrial plants, but there are few records of the identification and characterization of the activity of these compounds in marine organisms such as fungi, bacteria, sponges, ascidians, and cnidarians. Seaweed are a source of several already elucidated bioactive compounds, but few studies have described and characterized the activity of seaweed alkaloids with anti-inflammatory properties. In this review, we have gathered the current knowledge about marine alkaloids with anti-inflammatory activity and suggest future perspectives for the study and bioprospecting of these compounds.

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