scholarly journals Brain perfusion magnetic resonance imaging using pseudocontinuous arterial spin labeling in 314 dogs and cats

2021 ◽  
Author(s):  
Anne‐Cécile Hoffmann ◽  
Yannick Ruel ◽  
Kirsten Gnirs ◽  
Stella Papageorgiou ◽  
Luca Zilberstein ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Arterial Spin Labeling ◽  
Brain Perfusion ◽  
Spin Labeling ◽  
Perfusion Magnetic Resonance Imaging ◽  
Resonance Imaging

scholarly journals Acute Effects of Alcohol on Brain Perfusion Monitored with Arterial Spin Labeling Magnetic Resonance Imaging in Young Adults

2014 ◽  
Vol 34 (3) ◽  
pp. 472-479 ◽  
Author(s):  
Michael Marxen ◽  
Gabriela Gan ◽  
Daniel Schwarz ◽  
Eva Mennigen ◽  
Maximilian Pilhatsch ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Young Adults ◽  
Magnetic Resonance ◽  
Arterial Spin Labeling ◽  
Time Course ◽  
Regional Distribution ◽  
Brain Perfusion ◽  
Spin Labeling ◽  
Acute Tolerance ◽  
Resonance Imaging

While a number of studies have established that moderate doses of alcohol increase brain perfusion, the time course of such an increase as a function of breath alcohol concentration (BrAC) has not yet been investigated, and studies differ about regional effects. Using arterial spin labeling (ASL) magnetic resonance imaging, we investigated (1) the time course of the perfusion increase during a 15-minute linear increase of BrAC up to 0.6 g/kg followed by a steady exposure of 100 minutes, (2) the regional distribution, (3) a potential gender effect, and (4) the temporal stability of perfusion effects. In 48 young adults who participated in the Dresden longitudinal study on alcohol effects in young adults, we observed (1) a 7% increase of global perfusion as compared with placebo and that perfusion and BrAC are tightly coupled in time, (2) that the increase reaches significance in most regions of the brain, (3) that the effect is stronger in women than in men, and (4) that an acute tolerance effect is not observable on the time scale of 2 hours. Larger studies are needed to investigate the origin and the consequences of the effect, as well as the correlates of inter-subject variations.

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