scholarly journals A retrospective study of adverse effects of mycophenolate mofetil administration to dogs with immune‐mediated disease

2021 ◽  
Author(s):  
Kenjiro Fukushima ◽  
Michael Lappin ◽  
Marie Legare ◽  
Julia Veir
Keyword(s):  
Mycophenolate Mofetil ◽  
Retrospective Study ◽  
Adverse Effects ◽  
Immune Mediated

Drugs with potential cardiac adverse effects: Retrospective study in a large cohort of parkinsonian patients

2016 ◽  
Vol 172 (4-5) ◽  
pp. 318-323 ◽  
Author(s):  
A. Heranval ◽  
R. Lefaucheur ◽  
D. Fetter ◽  
A. Rouillé ◽  
F. Le Goff ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Adverse Effects ◽  
Large Cohort

scholarly journals CYP2D6 polymorphisms may predict occurrence of adverse effects to tamoxifen: a preliminary retrospective study

2017 ◽  
Vol Volume 9 ◽  
pp. 111-120
Author(s):  
Ishani Wickramage ◽  
Kamani Hemamala Tennekoon ◽  
Merenchi Arachchige Yasantha Ariyaratne ◽  
Sudeshini Hewage ◽  
Tharmini Sundralingam
Keyword(s):  
Retrospective Study ◽  
Adverse Effects

scholarly journals Delayed Immune-Mediated Adverse Effects of Polyalkylimide Dermal Fillers

2008 ◽  
Vol 144 (5) ◽  
Author(s):  
Jaume Alijotas-Reig ◽  
Victor Garcia-Gimenez ◽  
Francesc Miró-Mur ◽  
Miquel Vilardell-Tarrés
Keyword(s):  
Adverse Effects ◽  
Dermal Fillers ◽  
Immune Mediated

Utility of Anakinra in Acute Crystalline Diseases: A Retrospective Study Comparing a University Hospital with a Veterans Affairs Medical Center

2018 ◽  
Vol 46 (7) ◽  
pp. 748-750 ◽  
Author(s):  
Julianna Desmarais ◽  
Cong-Qiu Chu
Keyword(s):  
Retrospective Study ◽  
Adverse Effects ◽  
Medical Center ◽  
Veterans Affairs ◽  
Hospitalized Patients ◽  
University Hospital ◽  
Acute Gout ◽  
Efficacy And Safety ◽  
Inpatient Management ◽  
Gout Flares

Objective.To evaluate the efficacy and safety of anakinra in inpatient management of acute gout and pseudogout.Methods.Hospitalized patients with acute gout (n = 77) or pseudogout (n = 11) or both (n = 3) were analyzed for response to anakinra and adverse effects.Results.Half of all patients had comorbidities limiting the treatment choice. Anakinra was well tolerated, and 92% of gout flares and 79% of pseudogout flares responded to treatment.Conclusion.Anakinra is an effective and safe treatment for acute gout and pseudogout in hospitalized patients, particularly in those with comorbidities.

scholarly journals A novel melanoma therapy stirs up a storm: ipilimumab-induced thyrotoxicosis

2015 ◽  
Vol 2015 ◽  
Author(s):  
Christine Yu ◽  
Inder J Chopra ◽  
Edward Ha
Keyword(s):  
Adverse Effects ◽  
T Lymphocyte ◽  
Autoimmune Thyroiditis ◽  
Cytotoxic T Lymphocyte ◽  
Alternative Therapy ◽  
Thyroid Storm ◽  
Iopanoic Acid ◽  
Immune Mediated ◽  
Thyroid Function Testing ◽  
Function Testing

Summary Ipilimumab, a novel therapy for metastatic melanoma, inhibits cytotoxic T-lymphocyte apoptosis, causing both antitumor activity and significant autoimmunity, including autoimmune thyroiditis. Steroids are frequently used in treatment of immune-related adverse events; however, a concern regarding the property of steroids to reduce therapeutic antitumor response exists. This study describes the first reported case of ipilimumab-associated thyroid storm and implicates iopanoic acid as an alternative therapy for immune-mediated adverse effects. An 88-year-old woman with metastatic melanoma presented with fatigue, anorexia, decreased functional status, and intermittent diarrhea for several months, shortly after initiation of ipilimumab – a recombinant human monoclonal antibody to the cytotoxic T-lymphocyte-associated antigen 4 (CTLA4). On arrival, she was febrile, tachycardic, and hypertensive with a wide pulse pressure, yet non-toxic appearing. She had diffuse, non-tender thyromegaly. An electrocardiogram (EKG) revealed supraventricular tachycardia. Blood, urine, and stool cultures were collected, and empiric antibiotics were started. A computed tomography (CT) angiogram of the chest was negative for pulmonary embolism or pneumonia, but confirmed a diffusely enlarged thyroid gland, which prompted thyroid function testing. TSH was decreased at 0.16 μIU/ml (normal 0.3–4.7); free tri-iodothyronine (T3) was markedly elevated at 1031 pg/dl (normal 249–405), as was free thyroxine (T4) at 5.6 ng/dl (normal 0.8–1.6). With iopanoic acid and methimazole therapy, she markedly improved within 48 h, which could be attributed to lowering of serum T3 with iopanoic acid rather than to any effect of the methimazole. Ipilimumab is a cause of overt thyrotoxicosis and its immune-mediated adverse effects can be treated with iopanoic acid, a potent inhibitor of T4-to-T3 conversion. Learning points While ipilimumab more commonly causes autoimmune thyroiditis, it can also cause thyroid storm and clinicians should include thyroid storm in their differential diagnosis for patients who present with systemic inflammatory response syndrome. Immune-related adverse reactions usually occur after 1–3 months of ipilimumab and baseline thyroid function testing should be completed before initiation with ipilimumab. Conflicting data exist on the use of prednisone for treatment of CTLA4 adverse effects and its attenuation of ipilimumab's antitumor effect. Iopanoic acid may be considered as an alternative therapy in this setting.

scholarly journals The Effect of Systemic Methotrexate and Cyclosporine Combination Therapy inPsoriasis Vulgaris Patients in Bandung, Indonesia

2021 ◽  
Vol 33 (3) ◽  
pp. 200
Author(s):  
Oki Suwarsa ◽  
Fatima Aulia Khairani ◽  
Syawalika Ulya Isneny ◽  
Erda Avriyanti ◽  
Hartati Purbo Dharmadji ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Side Effects ◽  
Adverse Effects ◽  
Combination Therapy ◽  
Combination Treatment ◽  
Psoriasis Vulgaris ◽  
Severity Index ◽  
Dermatology Clinic ◽  
Significant Difference ◽  
Pasi Score

Background: Methotrexate (MTX) and cyclosporine have been used as effective systemic mono-therapy for psoriasis. Several factors are considered to switch monotherapy to combination therapy because monotherapy is no longer effective and has higher side effects. Hence,clinicians have avoided systemic therapy combinations due to its toxicity. However, some studies showed that this combination therapy could be usedeffectively for psoriasis patients. Purpose: This study aimed to analyze the efficacy and adverse effects of systemic MTX and cyclosporine combination therapy in Indonesian psoriasis vulgaris patients. Methods: The retrospective study assessed the effectiveness of 3 monthsmono-therapyand combination therapy of systemic MTX and cyclosporine in psoriasisvulgaris patients from 2016–2017 in Dermatology Clinic, Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia. Result: Psoriasis area and severity index (PASI) score 90 were achieved in the group MTX (50%) and cyclosporine group (50%), while none in the combination group.However, eight patients (50%) in group MTX and cyclosporine reached the primary endpoint of PASI 50. One patient in cyclosporine group had adverse effects on kidney profiles. Nonetheless, other patients had no biochemical changes. But, there was no significant difference in the change of PASI between each group (p=0.102). Conclusion: We propose that combination therapy of MTX and cyclosporine is relatively safe and efficacious in treating Indonesian psoriasis vulgaris patients. This combination treatment isas effective as MTX or cyclosporinemono-therapy.

scholarly journals Gambaran Kasus Kematian pada Korban Terpapar Alkohol yang Diautopsi di Bagian Ilmu Kedokteran Forensik dan Medikolegal RSUP Prof. Dr. R. D. Kandou Periode 2014 - 2017

2018 ◽  
Vol 10 (3) ◽  
pp. 195
Author(s):  
Angela A. Pangemanan ◽  
James Siwu ◽  
Nola T. S. Mallo
Keyword(s):  
Retrospective Study ◽  
Alcohol Consumption ◽  
Adverse Effects ◽  
Cause Of Death ◽  
Human Body ◽  
Age Group ◽  
Addictive Substance ◽  
Using Data ◽  
Death Cases

Abstract: Alcohol is an addictive substance that could cause adverse effects to human body. Moreover, it is also related to a variety of criminal acts. North Celebes is one of the provinces with the highest alcohol consumption in Indonesia. This study was aimed to describe the death cases exposed to alcohol that were autopsied at Prof. Dr. R. D Kandou Hospital Manado during 2014-2017. This was a descriptive retrospective study using data of visum et repertum. The results showed that there were 17 death cases exposed to alcohol. The majority were in 2016 as many as 6 cases (35.3%). The most common age group was 26-35 years as many as 7 cases (41.2%). All cases were males (100%). The most cause of death in these cases were due to violence using sharp objects as many as 15 cases (88.2%). Conclusion: Most death cases exposed to alcohol were males aged 26-35 years, and the cause of death was violence using sharp object.Keywords: alcohol, death casesAbstrak: Alkohol adalah zat adiktif yang dapat berdampak buruk bagi tubuh manusia serta terkait juga dengan berbagai tindakan kriminalitas. Sulawesi Utara merupakan salah satu provinsi dengan konsumen alkohol terbanyak di Indonesia. Penelitian ini bertujuan untuk mengetahui gambaran kasus kematian pada korban terpapar alkohol yang diautopsi di RSUP Prof. Dr. R. D Kandou periode 2014-2017. Jenis penelitian ialah deskriptif retrospektif menggunakan data hasil visum et repertum. Jenis penelitian ialah deskriptif retrospektif. Hasil penelitian mendapatkan 17 kasus kematian korban terpapar alkohol. Kasus terbanyak pada tahun 2016 yaitu 6 kasus (35,3%). Kelompok usia terbanyak 26-35 tahun yaitu 7 kasus (41,2%) dan jenis kelamin laki-laki (100%). Penyebab kematian terpapar alkohol terbanyak karena kekerasan benda tajam yaitu 15 kasus (88,2%). Simpulan: Sebagian besar kasus kematian akibat terpapar alkohol berada dalam kelompok usia 26-35 tahun, semua berjenis kelamin laki-laki, dengan jenis penyebab kematian akibat kekerasan benda tajam.Kata kunci: alkohol, kasus kematian

scholarly journals Efficacy and Safety of Rituximab in Immunobullous Diseases: A Retrospective Study from a Tertiary Care Centre of Nepal

2020 ◽  
Author(s):  
Sudip Parajuli ◽  
Jyoti Vidhan ◽  
Dinesh Binod Pokhrel ◽  
Upama Paudel
Keyword(s):  
Retrospective Study ◽  
Adverse Effects ◽  
Tertiary Care ◽  
Data Entry ◽  
Pemphigus Vulgaris ◽  
University Teaching ◽  
Efficacy And Safety ◽  
Tertiary Care Centre ◽  
Cutaneous Lesions

Introduction: Rituximab is effective and safe treatment of immunobullous disorders. There are variations in doses of drugs used in different studies and uncertainties on when to use it along with use of adjuvant therapies. Efficacy and safety of this drug has not been described in Nepalese population till date. Dermatologists have hesitation in starting this drug in immunobullous diseases because of lack of data on efficacy and safety. Aim: To assess the efficacy and side effects of Rituximab therapy in treating immunobullous disorders in Nepalese patients. Materials and Methods: This was a retrospective study of patients with immunobullous diseases treated with Rituximab in Dermatological ward of Tribhuvan University Teaching Hospital, Kathmandu, Nepal from May 2018 to August 2019. Data were analysed for duration of disease and treatment received before Rituximab therapy, duration of steroid used before Rituximab, adverse effects due to prolonged steroid use, time to remission from 1st Rituximab pulse, duration of remission, relapse, duration of steroid and adjuvant drug used post 1st pulse and adverse effects associated with Rituximab. SPSS version 20 was used for data entry and descriptive statistics was used for analysis of the data. Results: Nine patients (Pemphigus Vulgaris-8 (PV-8), Bullous Pemphigoid-1 (BP-1) were treated with Rituximab. Seven were treated for refractory disease not controlled by conventional therapy and two received Rituximab as first-line therapy. The patients were under follow-up for 15-60 weeks (mean 31.89±15.62 weeks). Out of these nine patients, eight were free of lesions in one to eight weeks (mean 5.125±2 weeks) of first pulse. One patient with Oral Pemphigus had persistence of old lesions, however there were no new cutaneous lesions after first pulse. Adverse effects were seen in four patients that included infusion reaction in one and infection in three. There was relapse in one patient at last follow-up. Conclusion: Rituximab is efficacious and is safe in treating immunobullous disorders in Nepalese Population.

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