scholarly journals Successful nutritional control of scratching and clinical signs associated with adverse food reaction: A randomized controlled COSCAD '18 adherent clinical trial in dogs in the United States

2021 ◽  
Author(s):  
James L. Weemhoff ◽  
Jennifer M. MacLeay ◽  
John Brejda ◽  
Heidi Schiefelbein ◽  
Susan M. Wernimont ◽  
...  
Keyword(s):  
United States ◽  
Clinical Trial ◽  
Clinical Signs ◽  
The United States ◽  
Randomized Controlled ◽  
Adverse Food Reaction

Cryotherapy for Retinopathy of Prematurity

2020 ◽  
pp. 145-150
Author(s):  
Alan D. Penman ◽  
Kimberly W. Crowder ◽  
William M. Watkins
Keyword(s):  
United States ◽  
Clinical Trial ◽  
Retinopathy Of Prematurity ◽  
Neonatal Screening ◽  
Threshold Level ◽  
The United States ◽  
Multicenter Trial ◽  
Long Term Results ◽  
Randomized Controlled

The Multicenter Trial of Cryotherapy for Retinopathy of Prematurity (CRYO-ROP) was a randomized, controlled, interventional clinical trial to determine whether cryotherapy was effective in reducing the unfavorable ocular outcomes from threshold retinopathy of prematurity (ROP). The study showed that at a 3-month assessment, cryotherapy was significantly beneficial for eyes with ROP at a defined threshold level of severity. The findings of the CRYO-ROP study led to the implementation of neonatal screening and peripheral retinal ablation for acute ROP throughout the United States and beyond. Long-term results of CRYO-ROP have also influenced the management of affected patients throughout the remainder of childhood.

scholarly journals Dissemination of the Look AHEAD Intensive Lifestyle Intervention in the United States Military: A Randomized Controlled Trial

Obesity ◽  
2018 ◽  
Vol 26 (10) ◽  
pp. 1558-1565 ◽  
Author(s):  
Rebecca A. Krukowski ◽  
Marion E. Hare ◽  
Gerald W. Talcott ◽  
Leslie A. Gladney ◽  
Karen C. Johnson ◽  
...  
Keyword(s):  
United States ◽  
Randomized Controlled Trial ◽  
Lifestyle Intervention ◽  
Controlled Trial ◽  
The United States ◽  
United States Military ◽  
Randomized Controlled ◽  
Intensive Lifestyle Intervention ◽  
Look Ahead ◽  
The Look

scholarly journals Using Stories to Communicate Individual Risk for Opioid Prescriptions: Study Protocol for the Life STORRIED Multicenter Randomized Clinical Trial

2018 ◽  
Author(s):  
Zachary F Meisel ◽  
Esha Bansal ◽  
Marilyn M Schapira ◽  
Jeanmarie Perrone ◽  
Carolyn C Cannuscio ◽  
...  
Keyword(s):  
United States ◽  
Clinical Trial ◽  
Risk Communication ◽  
Randomized Clinical Trial ◽  
Acute Care ◽  
Acute Pain ◽  
The United States ◽  
Risk Information ◽  
Information Sheet ◽  
Health Crisis

Abstract Background: Prescription opioid abuse in the United States is a devastating public health crisis, of which many chronic opioid users were originally prescribed the medication for acute pain. Narrative enhanced risk communication may improve patient outcomes such as knowledge of opioid risk and opioid use behaviors in the setting of acute pain. Methods & Design: Patients presenting to the acute care facilities of four geographically and ethnically diverse United States hospital centers with renal colic or musculoskeletal back pain will be eligible for this multicenter randomized clinical trial. A control group of patients receiving a standardized, general risk information sheet will be compared to two intervention groups, one receiving the risk information sheet plus a probabilistic opioid risk tool and another receiving the risk information sheet plus a narrative enhanced probabilistic opioid risk tool. We will study the effect of probabilistic and narrative enhanced opioid risk communication on: 1) knowledge as measured by risk awareness and treatment preferences for fewer opioids; 2) reduced use of opioids as measured by quantity of opioids taken, functional improvement, and repeat use of unscheduled visits for pain; 3) patient-provider alignment as measured by concordance between patient preference and finalized prescription plan and the presence of shared decision making. To assess these outcomes, we will administer baseline patient surveys during acute care admission and follow-up surveys at predetermined times during the ninety days after discharge. Discussion: This study seeks to assess the potential clinical role of narrative enhanced, risk-informed communication for acute pain management in acute care settings. This paper outlines the protocol used to implement the study and highlights crucial methodological, statistical, stakeholder involvement, and dissemination considerations.

scholarly journals Effects of Side-Effect Risk Framing Strategies on COVID-19 Vaccine Intentions in the United States and the United Kingdom: A Randomized Controlled Trial

2021 ◽  
Author(s):  
Nikkil Sudharsanan ◽  
Caterina Favaretti ◽  
Violetta Hachaturyan ◽  
Till Baernighausen ◽  
Alain Vandormael
Keyword(s):  
United States ◽  
Randomized Controlled Trial ◽  
Side Effect ◽  
Motor Vehicle ◽  
Controlled Trial ◽  
The United States ◽  
Randomized Controlled ◽  
The United Kingdom ◽  
Percentage Points ◽  
Framing Strategies

Vaccination rates have stagnated in the United States and the United Kingdom leading to the continuing spread of COVID-19. Fear and concern over vaccine side-effects is one of the main drivers of hesitancy. Drawing from behavioral science and health communication theory, we conducted a randomized controlled trial among 8998 adults to determine whether the way COVID-19 vaccine side-effects are framed and presented to individuals can influence their willingness to take a vaccine. We presented participants information on a hypothetical future COVID-19 vaccine -- including information on its side-effect rate -- and then examined the effect of three side-effect framing strategies on individuals stated willingness to take this vaccine: adding a qualitative risk label next to the numerical risk, adding comparison risks, and for those presented with comparisons, framing the comparison in relative rather than absolute terms. Based on a pre-registered and published analysis plan, we found that adding a simple descriptive risk label (very low risk) next to the numerical side-effect increased participants' willingness to take the COVID-19 vaccine by 3.0 percentage points (p = 0.003). Providing a comparison to motor vehicle mortality increased COVID-19 vaccine willingness by 2.4 percentage points (p = 0.051). These effects were independent and additive: participants that received both a qualitative risk label and comparison to motor-vehicle mortality were 6.1 percentage points (p < 0.001) more likely to report willingness to take a vaccine compared to those who did not receive a label or comparison. Taken together, our results reveal that despite increasingly strong vaccination hesitancy and exposure to large amounts of vaccine misinformation, low-cost side-effect framing strategies can meaningfully affect vaccination intentions at a population level.

Peer Support and the HIV Continuum of Care: Results from a Multi-Site Randomized Clinical Trial in Three Urban Clinics in the United States

2018 ◽  
Vol 22 (8) ◽  
pp. 2627-2639 ◽  
Author(s):  
Howard J. Cabral ◽  
Kendra Davis-Plourde ◽  
Mariana Sarango ◽  
Jane Fox ◽  
Joseph Palmisano ◽  
...  
Keyword(s):  
United States ◽  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Peer Support ◽  
The United States ◽  
Continuum Of Care ◽  
Hiv Continuum Of Care

Trial of Therapy and Prospective Study of Nephroblastoma

PEDIATRICS ◽  
1972 ◽  
Vol 49 (4) ◽  
pp. 638-639
Author(s):  
P. A. Voûte ◽  
J. Lemerle
Keyword(s):  
United States ◽  
Clinical Trial ◽  
Radiation Therapy ◽  
Prospective Study ◽  
International Society ◽  
Pediatric Oncology ◽  
The United States ◽  
Therapeutic Trial ◽  
A Prospective Study

The International Society of Pediatric Oncology (ISPO) is planning a clinical therapeutic trial on nephroblastoma in Europe. Large agreement exists on the treatment of these tumors; the principal modalities are surgery, radiation therapy, and chemotherapy. However, there are some unanswered questions as to the value of different forms of administration of radiation and chemotherapy, which we feel could best be elucidated by a prospective study in the form of a clinical trial. A trial has been going on in the United States for 2 years.

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