scholarly journals Effect of doxepin on quality of life in Labradors with laryngeal paralysis: A double‐blinded, randomized, placebo‐controlled trial

Author(s):  
Mark Rishniw ◽  
Jill Sammarco ◽  
Eric N. Glass ◽  
Brittany Cerroni
Trials ◽  
2012 ◽  
Vol 13 (1) ◽  
Author(s):  
Paulo de Tarso Camillo de Carvalho ◽  
Ernesto Cesar Pinto Leal-Junior ◽  
Ana Carolina Araruna Alves ◽  
Caroline Sobral de Melo Rambo ◽  
Luciana Maria Malosa Sampaio ◽  
...  

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Afsoon Emami Naini ◽  
Mahnaz Moradi ◽  
Mojgan Mortazavi ◽  
Asghar Amini Harandi ◽  
Mehdi Hadizadeh ◽  
...  

In patients on maintenance hemodialysis several factors reduce the body stored carnitine which could lead to dyslipidemia, anemia, and general health in these patients. We evaluated the effect of oral L-carnitine supplementation on lipid profiles, anemia, and quality of life (QOL) in hemodialysis patients. In a randomized, double-blinded, placebo-controlled trial, end-stage renal disease (ESRD) patients on hemodialysis received either L-carnitine 1 g/d (n=24) or placebo (27 patients) for 16 weeks. At the end of the study, there was a significant decrease in triglyceride (-31.1±38.7 mg/dL,P=0.001) and a significant increase in HDL (3.7±2.8 mg/dL,P<0.001) levels in the carnitine group. Decrease in total cholesterol (−6.6±16.0 mg/dL,P=0.075) and increase in hemoglobin (0.7±1.7 g/dL,P=0.081) concentrations in the carnitine group were not significant. There was no statistically significant changes in LDL in any group (P>0.05). Erythropoietin dose was significantly decreased in both the carnitine (-4750±5772 mg,P=0.001) and the placebo group (-2000±4296 mg,P<0.05). No improvement was observed in QOL scores of two groups. In ESRD patients under maintenance hemodialysis, oral L-carnitine supplementation may reduce triglyceride and cholesterol and increase HDL and hemoglobin and subsequently reduce needed erythropoietin dose without effect on QOL.


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