scholarly journals A hypomyelinating leukodystrophy in German Shepherd dogs

2021 ◽  
Author(s):  
Pia R. Quitt ◽  
Andreas Brühschwein ◽  
Kaspar Matiasek ◽  
Franziska Wielaender ◽  
Veera Karkamo ◽  
...  
Keyword(s):  
German Shepherd ◽  
Hypomyelinating Leukodystrophy

Estimation of heritability for hip dysplasia in German Shepherd Dogs in Finland

2000 ◽  
Vol 117 (3) ◽  
pp. 97-103 ◽  
Author(s):  
M. Leppänen ◽  
K. Mäki ◽  
J. Juga ◽  
H. Saloniemi
Keyword(s):  
Hip Dysplasia ◽  
German Shepherd

Taeniasis in a German Shepherd Pup: A Case Report

2019 ◽  
Vol 15 (01) ◽  
pp. 83-84
Author(s):  
B J Thakre ◽  
Joice P Joseph ◽  
Binod Kumar ◽  
Nilima Brahmbhatt ◽  
Krishna Gamit
Keyword(s):  
Case Report ◽  
Life Cycle ◽  
Definitive Host ◽  
Gastrointestinal Diseases ◽  
Intermediate Hosts ◽  
German Shepherd ◽  
Taenia Hydatigena ◽  
Taenia Multiceps ◽  
Taenia Crassiceps ◽  
Dipylidium Caninum

Taenia spp. are long, segmented, parasitic tapeworms and are relatively uncommon in canine gastrointestinal diseases compared to other tapeworms like Dipylidium caninum. These parasites have an indirect life cycle, cycling between definitive and intermediate hosts. Dogs act as definitive hosts of different species of Taenia including Taenia multiceps, Taenia serialis, Taenia crassiceps, Taenia hydatigena, Taenia pisiformis, etc. Taenia multiceps is of greatest zoonotic relevance in human. In the definitive host, it causes only mild infection. Larvae are more likely to cause disease than adult tapeworms. Taeniasis in pets should be cautiously handled because of its zoonotic importance. This communication reports a case of 3 months old pup suffering from Taenia infection that was successfully managed with a combination of praziquantel and fenbendazole.

scholarly journals Genomic association and further characterisation of faecal immunoglobulin A deficiency in German Shepherd dogs

2021 ◽  
Author(s):  
Niels Grützner ◽  
Romy M. Heilmann ◽  
Ursula Tress ◽  
Iain R. Peters ◽  
Jan S. Suchodolski ◽  
...  
Keyword(s):  
Immunoglobulin A ◽  
German Shepherd ◽  
Genomic Association

Dwarfism in Tibetan Terrier dogs with an LHX3 mutation

2021 ◽  
pp. 104063872110075
Author(s):  
Tuddow Thaiwong ◽  
Sarah Corner ◽  
Stacey La Forge ◽  
Matti Kiupel
Keyword(s):  
Hair Loss ◽  
Autosomal Recessive ◽  
Early Death ◽  
Deletion Mutation ◽  
Recessive Trait ◽  
Autosomal Recessive Trait ◽  
German Shepherd ◽  
Hair Coat ◽  
Pituitary Dwarfism ◽  
Autosomal Recessive Manner

Canine pituitary dwarfism in German Shepherd and related dog breeds has been reported to be associated with a 7-bp deletion mutation in intron 5 of the LHX3 gene. This mutation is transmitted as an autosomal recessive trait that results in dwarf dogs with significantly smaller stature and abnormal haircoat, and potentially early death. Phenotypically, affected adult dogs are proportionally dwarfs. These dwarfs also have a soft, woolly puppy coat that fails to transition into the typical adult hair coat, and marked hair loss occurs in some dogs. We report a similar manifestation of dwarfism in Tibetan Terriers with the same LHX3 mutation. Dwarf Tibetan Terrier puppies were born physically normal but failed to gain weight or to grow at the same rate as their normal littermates. The 7-bp deletion mutation of the LHX3 gene was identified in both alleles of 3 Tibetan Terrier dwarfs from 3 litters, which were biologically related. All parents of these dogs are carriers, confirming transmission of dwarfism in an autosomal recessive manner. Recognition and detection of this mutation will help in guiding future breeding plans to eventually eliminate this trait from Tibetan Terriers.

scholarly journals Czechoslovakian Wolfdog Genomic Divergence from Its Ancestors Canis lupus, German Shepherd Dog, and Different Sheepdogs of European Origin

Genes ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 832
Author(s):  
Nina Moravčíková ◽  
Radovan Kasarda ◽  
Radoslav Židek ◽  
Luboš Vostrý ◽  
Hana Vostrá-Vydrová ◽  
...  
Keyword(s):  
Demographic History ◽  
Genome Structure ◽  
Principal Component ◽  
Genetic Distances ◽  
Nucleotide Polymorphisms ◽  
German Shepherd ◽  
German Shepherd Dog ◽  
Genome Wide ◽  
Scale Population ◽  
History Effect

This study focused on the genomic differences between the Czechoslovakian wolfdog (CWD) and its ancestors, the Grey wolf (GW) and German Shepherd dog. The Saarloos wolfdog and Belgian Shepherd dog were also included to study the level of GW genetics retained in the genome of domesticated breeds. The dataset consisted of 131 animals and 143,593 single nucleotide polymorphisms (SNPs). The effects of demographic history on the overall genome structure were determined by screening the distribution of the homozygous segments. The genetic variance distributed within and between groups was quantified by genetic distances, the FST index, and discriminant analysis of principal components. Fine-scale population stratification due to specific morphological and behavioural traits was assessed by principal component and factorial analyses. In the CWD, a demographic history effect was manifested mainly in a high genome-wide proportion of short homozygous segments corresponding to a historical load of inbreeding derived from founders. The observed proportion of long homozygous segments indicated that the inbreeding events shaped the CWD genome relatively recently compared to other groups. Even if there was a significant increase in genetic similarity among wolf-like breeds, they were genetically separated from each other. Moreover, this study showed that the CWD genome carries private alleles that are not found in either wolves or other dog breeds analysed in this study.

scholarly journals Mutations of POLR3A Encoding a Catalytic Subunit of RNA Polymerase Pol III Cause a Recessive Hypomyelinating Leukodystrophy p415

2012 ◽  
Vol 91 (5) ◽  
pp. 972 ◽  
Author(s):  
Geneviève Bernard ◽  
Eliane Chouery ◽  
Maria Lisa Putorti ◽  
Martine Tétreault ◽  
Asako Takanohashi ◽  
...  
Keyword(s):  
Rna Polymerase ◽  
Catalytic Subunit ◽  
Pol Iii ◽  
Hypomyelinating Leukodystrophy
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