scholarly journals Association of diet with left ventricular wall thickness, troponin I and IGF ‐1 in cats with subclinical hypertrophic cardiomyopathy

2020 ◽  
Vol 34 (6) ◽  
pp. 2197-2210
Author(s):  
Ingrid Hoek ◽  
Hannah Hodgkiss‐Geere ◽  
Elizabeth F. Bode ◽  
Julie Hamilton‐Elliott ◽  
Paul Mõtsküla ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Wall Thickness ◽  
Troponin I ◽  
Left Ventricular ◽  
Left Ventricular Wall ◽  
Ventricular Wall ◽  
Left Ventricular Wall Thickness ◽  
Ventricular Wall Thickness

scholarly journals Discordant clinical features of identical hypertrophic cardiomyopathy twins

2021 ◽  
Vol 118 (10) ◽  
pp. e2021717118 ◽  
Author(s):  
Giuliana G. Repetti ◽  
Yuri Kim ◽  
Alexandre C. Pereira ◽  
Jodie Ingles ◽  
Mark W. Russell ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Disease Progression ◽  
Wall Thickness ◽  
Left Ventricular ◽  
Left Ventricular Wall ◽  
Left Ventricular Ejection ◽  
Ventricular Wall ◽  
Left Ventricular Wall Thickness ◽  
Clinical Expression ◽  
Ventricular Wall Thickness

Hypertrophic cardiomyopathy (HCM) is a disease of heart muscle, which affects ∼1 in 500 individuals and is characterized by increased left ventricular wall thickness. While HCM is caused by pathogenic variants in any one of eight sarcomere protein genes, clinical expression varies considerably, even among patients with the same pathogenic variant. To determine whether background genetic variation or environmental factors drive these differences, we studied disease progression in 11 pairs of monozygotic HCM twins. The twin pairs were followed for 5 to 14 y, and left ventricular wall thickness, left atrial diameter, and left ventricular ejection fraction were collected from echocardiograms at various time points. All nine twin pairs with sarcomere protein gene variants and two with unknown disease etiologies had discordant morphologic features of the heart, demonstrating the influence of nonhereditable factors on clinical expression of HCM. Whole genome sequencing analysis of the six monozygotic twins with discordant HCM phenotypes did not reveal notable somatic genetic variants that might explain their clinical differences. Discordant cardiac morphology of identical twins highlights a significant role for epigenetics and environment in HCM disease progression.

Sign in / Sign up

Export Citation Format

Share Document