scholarly journals Effects of pH and the plasma or serum concentrations of total calcium, chloride, magnesium,l‐lactate, and albumin on the plasma ionized calcium concentration in calves

2019 ◽  
Vol 33 (4) ◽  
pp. 1822-1832 ◽  
Author(s):  
Peter Constable ◽  
Florian M. Trefz ◽  
Henry Stämpfli
Keyword(s):  
Calcium Chloride ◽  
Calcium Concentration ◽  
Ionized Calcium ◽  
Serum Concentrations ◽  
Total Calcium ◽  
Effects Of Ph

Effect of Hypocalcemia on Cardiac Function in Very-Low-Birth-Weight Preterm Neonates: Studies of Blood Ionized Calcium, Echocardiography, and Cardiac Effect of Intravenous Calcium Therapy

PEDIATRICS ◽  
1985 ◽  
Vol 76 (4) ◽  
pp. 543-550
Author(s):  
Pankaja S. Venkataraman ◽  
Don A. Wilson ◽  
Roger E. Sheldon ◽  
Radhakrishna Rao ◽  
Michael K. Parker
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Cardiac Function ◽  
Serum Calcium ◽  
Calcium Concentration ◽  
Very Low Birth Weight ◽  
Left Ventricular ◽  
Ionized Calcium ◽  
Total Calcium ◽  
Serum Total Calcium

Traditionally, in infants, a serum calcium value less than 7.0 mg/dL is considered to impair cardiac function. In very-low-birth-weight infants, we studied the hypotheses that decline in serum calcium to 6.0 mg/dL (1) would not impair cardiac function and (2) ionized calcium would remain greater than 3.0 mg/dL. We also evaluated the effect of calcium infusion on cardiac function. We studied 15 normokalemic and normonatremic infants whose birth weights were 822 to 1,450 g and were less than 32 weeks' gestation. When serum calcium declined to less than 6.0 mg/dL, 18 mg/kg of calcium as 5% calcium gluconate was infused for 10 minutes. Serum total calcium concentration, blood ionized calcium concentration, ECG, and M-mode echocardiogram were obtained on entry into the study, when the infants were hypocalcemic, immediately after treatment with calcium, and eight hours after treatment. Ionized calcium values were calculated based on serum total calcium and serum protein, and corrected calcium values were calculated based on serum total calcium, serum albumin, and blood pH. In all infants, serum calcium value declined to less than 7.0 and in eight infants to less than 6.0 mg/dL. Assessment of heart rate, systolic blood pressure, ejection fraction, left ventricular systolic time interval, right ventricular systolic time interval, fiber shortening index, and left ventricular mean velocity of circumferential fiber shortening showed no significant alteration from baseline during hypocalcemia or in association with intravenous slow bolus infusion of 18 mg/kg of calcium. In association with a decline in serum total calcium to as low as 6.0 mg/dL, whole blood ionized calcium was maintained at more than 3.0 mg/dL. Serum total calcium and calculated ionized calcium values correlated significantly with measured blood ionized calcium concentrations; however, these measures were not reliable predictors of blood ionized calcium. We speculate that the hypoproteinemia and hypoalbuminemia noted in these infants may result in relative protection of the blood ionized calcium in these infants. We suggest that in neonates with wide ranges in gestation, serum protein, and blood pH levels, total serum calcium and calculated ionized calcium values may be poor measures of derangement of calcium metabolism. Decline in total serum calcium concentration to 6.0 mg/dL was not associated with impaired cardiac function, and slow bolus calcium infusion in these hypocalcemic very-low-birth-weight infants neither improved nor impaired cardiac function.

Albumin-adjusted calcium concentration in serum increases during normal pregnancy

1990 ◽  
Vol 36 (1) ◽  
pp. 142-144 ◽  
Author(s):  
R B Payne ◽  
A J Little ◽  
R T Evans
Keyword(s):  
Calcium Concentration ◽  
Normal Pregnancy ◽  
Ionized Calcium ◽  
Albumin Concentration ◽  
Total Calcium

Abstract Concentrations of total calcium and albumin were measured in serum specimens from 41 women at intervals before, during, and after 42 pregnancies. The albumin concentration decreased but the calcium decreased more slowly, so that the albumin-adjusted calcium concentration increased from conception to term. These findings, taken in conjunction with published observations of hypercalciuria, increased concentrations of 1,25-dihydroxycholecalciferol and calcitonin in serum, and decreased concentrations of intact parathyrin in serum, strongly suggest that maternal ionized calcium increases throughout normal pregnancy.

Effect of pH on interaction of calcium ions with serum proteins

1961 ◽  
Vol 201 (2) ◽  
pp. 386-392 ◽  
Author(s):  
N. A. Peterson ◽  
G. A. Feigen ◽  
J. M. Crismon
Keyword(s):  
Total Protein ◽  
Calcium Concentration ◽  
Serum Proteins ◽  
Ion Concentration ◽  
Rabbit Serum ◽  
Total Calcium ◽  
Effect Of Ph ◽  
Effects Of Ph ◽  
Simple Linear Equation ◽  
Calcium Ion Concentration

A study has been made of the effect of pH on the dissociation of calcium proteinate in rabbit serum. Equations were derived from the experimental data which define a) the effect of serum pH on the McLean-Hastings dissociation constant for the dissociation of calcium proteinate; b) the relationship between the serum pH and the concentration of calcium which is ultrafiltrable; c) the effects of pH, total protein, and total calcium concentration on the change in calcium ion concentration (ultrafiltrable calcium) per unit change in pH. A simple, linear equation was derived from the data which gives serum ultrafiltrable calcium concentration in terms of pH, total protein, and total calcium concentration. A similar study on the dissociation of calcium proteinate was made on purified bovine serum albumin. The results obtained with this system were similar to those obtained on rabbit serum, but the scattering of the data in the case of the purified protein system was far less pronounced. The data on purified albumin was used to re-examine some of the relationships which were derived from the data on rabbit serum.

Plasma Magnesium and Calcium Levels in Depressive Psychosis

1972 ◽  
Vol 120 (559) ◽  
pp. 683-684 ◽  
Author(s):  
G. J. Naylor ◽  
Laura W. Fleming ◽  
W. K. Stewart ◽  
H. B. McNamee ◽  
D. Le Poidevin
Keyword(s):  
Divalent Cation ◽  
Calcium Concentration ◽  
Depressive Illness ◽  
Plasma Calcium ◽  
Ionized Calcium ◽  
Total Plasma ◽  
Total Calcium ◽  
Before And After ◽  
Plasma Calcium Concentration ◽  
Plasma Magnesium

There have been reports of the association of alterations in the divalent cation content of plasma with depressive illness. Coirault and colleagues (1959) found increased ionized calcium levels despite decreased total plasma calcium concentration in patients recovered from depression. More recently, Frizel and colleagues (1969) have reported normal plasma ionized and total calcium levels both before and after recovery from depression.

Calcium and magnesium in essential hypertension

1988 ◽  
Vol 75 (4) ◽  
pp. 395-402 ◽  
Author(s):  
D. M. Tillman ◽  
P. F. Semple
Keyword(s):  
Essential Hypertension ◽  
Urinary Excretion ◽  
Systolic Pressure ◽  
Ionized Calcium ◽  
Serum Concentrations ◽  
Total Calcium ◽  
Control Subjects ◽  
Calcium Magnesium ◽  
The Difference ◽  
And Control

1. Because disturbances of calcium metabolism have been described in hypertension, measurements of plasma and serum concentrations of ionized calcium, total calcium, magnesium and renin were made in 38 patients with essential hypertension and age- and sex-matched control subjects. Urinary excretion of calcium, magnesium and sodium was also determined. 2. The mean serum concentration of ionized calcium was 1.23 ± 0.04 (sd) mmol/l in the hypertensive group and 1.21 ±0.03 mmol/l in controls, and results were similar after correction for pH. There was a weak positive correlation between serum ionized calcium (pH 7.4) and systolic pressure (r = 0.26, P < 0.02), but no correlation with plasma renin concentration. 3. Although the difference between serum total calcium concentration in the hypertensive (2.29 ±0.09 mmol/l) and control (2.26 ±0.07 mmol/l) subjects was not significant, there was a significant correlation between total calcium and systolic pressure (r = 0.23, P < 0.05) which was maintained after correction for other variables. 4. There were no differences in plasma concentrations of parathyroid hormone or 1,25-dihydroxycholecalciferol between hypertensive and control subjects. 5. The hypertensive group showed higher urinary excretion of calcium (5.9 ±3.0 mmol/24h) than controls (4.6 ± 1.7 mmol/24 h), but the difference was not maintained after correction for sodium excretion. 6. Serum concentrations of magnesium were similar in the two groups, but urinary excretion of magnesium was significantly lower in hypertensive (3.7 ± 1.3 mmol/24 h) than control (4.5 ±1.6 mmol/24 h) subjects and there was an inverse correlation between magnesium excretion and blood pressure (r = 0.3–0.35, P < 0.01).

scholarly journals Biochemical serum profile of quarter mile equines in team penning training

2020 ◽  
Vol 36 (5) ◽  
Author(s):  
Roberta de Lima Santos ◽  
Renata Dias Rodrigues ◽  
Lara Reis Gomes ◽  
Amanda Bizare ◽  
Wilson Junior Oliveira ◽  
...  
Keyword(s):  
Average Duration ◽  
Ionized Calcium ◽  
Serum Concentrations ◽  
Total Calcium ◽  
Total Proteins ◽  
Physical Exercises ◽  
Aspartate Amino Transferase ◽  
Before And After ◽  
Calcium Phosphorus ◽  
Glutamyl Transferase

The objective of this work was to evaluate the proteins, minerals, metabolites, and serum enzymes profile in Quarter Mile equines subjected to training for Team Penning competitions by comparing the results before and after training. The animals were from the Agricultural Exhibition Park of Uberlândia (CAMARU), in Uberlândia in the State of Minas Gerais, Brazil. These animals perform constant periodic training with an average duration of two and a half hours per training. Blood samples from twenty male and female equines were collected at the beginning and end of a 45-day interval and then analyzed. A 5 mL blood sample from each animal was collected before and after training by a jugular external venipuncture, and the samples were placed in a tube—without anticoagulant and containing separator gel—to obtain the serum. The components analyzed were: total proteins, albumin, globulins, albumin to globulin ratio (A:G), total and ionized calcium, phosphorus, calcium to phosphorus ratio (Ca:P), cholesterol, triglycerides, creatinine, urea, alkaline phosphatase, ɤ-glutamyl transferase, lactate dehydrogenase (LDH), aspartate amino transferase (AST), alanine aminotransferase (ALT) and creatine kinase (CK). Statistical differences were observed with higher values after exercise for total calcium, ionized calcium, Ca: P ratio, creatinine and ALT and decreased concentrations were found for globulins, phosphorus, cholesterol and triglycerides. Despite the changes observed in the serum concentrations of some elements after exercises, it was concluded that the animals were in adequate physical condition to perform the proposed physical exercises.

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