scholarly journals Serum Concentrations of Symmetric Dimethylarginine and Creatinine in Dogs with Naturally Occurring Chronic Kidney Disease

2016 ◽  
Vol 30 (3) ◽  
pp. 794-802 ◽  
Author(s):  
J.A. Hall ◽  
M. Yerramilli ◽  
E. Obare ◽  
M. Yerramilli ◽  
K. Almes ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Serum Concentrations ◽  
Symmetric Dimethylarginine ◽  
Naturally Occurring

scholarly journals Evaluation of profibrotic gene transcription in renal tissues from cats with naturally occurring chronic kidney disease

2020 ◽  
Vol 34 (4) ◽  
pp. 1476-1487
Author(s):  
Bianca N. Lourenço ◽  
Amanda E. Coleman ◽  
Jaime L. Tarigo ◽  
Roy D. Berghaus ◽  
Cathy A. Brown ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Gene Transcription ◽  
Naturally Occurring

scholarly journals The fecal microbiome and serum concentrations of indoxyl sulfate and p‐cresol sulfate in cats with chronic kidney disease

2018 ◽  
Vol 33 (2) ◽  
pp. 662-669 ◽  
Author(s):  
Stacie C. Summers ◽  
Jessica M. Quimby ◽  
Anitha Isaiah ◽  
Jan S. Suchodolski ◽  
Paul J. Lunghofer ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Indoxyl Sulfate ◽  
Serum Concentrations ◽  
Fecal Microbiome

scholarly journals The Association between Gut Microbiota and Uremia of Chronic Kidney Disease

2020 ◽  
Vol 8 (6) ◽  
pp. 907 ◽  
Author(s):  
Ji Eun Kim ◽  
Hyo-Eun Kim ◽  
Ji In Park ◽  
Hyunjeong Cho ◽  
Min-Jung Kwak ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Gut Microbiota ◽  
Kidney Function ◽  
Kidney Diseases ◽  
Toxin Production ◽  
Positive Interactions ◽  
Uremic Toxin ◽  
Serum Concentrations ◽  
Pyruvate Metabolism

Chronic kidney disease (CKD)-associated uremia aggravates—and is aggravated by—gut dysbiosis. However, the correlation between CKD severity and gut microbiota and/or their uremic metabolites is unclear. We enrolled 103 CKD patients with stage 1 to 5 and 46 healthy controls. We analyzed patients’ gut microbiota by MiSeq system and measured the serum concentrations of four uremic metabolites (p-cresyl sulfate, indoxyl sulfate, p-cresyl glucuronide, and trimethylamine N-oxide) by liquid chromatography–tandem mass spectrometry. Serum concentrations of the uremic metabolites increased with kidney function deterioration. Gut microbial diversity did not differ among the examined patient and control groups. In moderate or higher stage CKD groups, Oscillibacter showed positive interactions with other microbiota, and the proportions of Oscillibacter were positively correlated with those of the uremic metabolites. The gut microbiota, particularly Oscillibacter, was predicted to contribute to pyruvate metabolism which increased with CKD progression. Relative abundance of Oscillibacter was significantly associated with both serum uremic metabolite levels and kidney function. Predicted functional analysis suggested that kidney-function-associated changes in the contribution of Oscillibacter to pyruvate metabolism in CKD may greatly affect the gut environment according to kidney function, resulting in dysbiosis concomitant with uremic toxin production. The gut microbiota could be associated with uremia progression in CKD. These results may provide basis for further metagenomics analysis of kidney diseases.

Diagnosis of the cat with early chronic kidney disease

2020 ◽  
Vol 25 (5) ◽  
pp. 118-124
Author(s):  
Ellie Groves
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Therapeutic Strategies ◽  
Dietary Management ◽  
Slow Disease Progression ◽  
Symmetric Dimethylarginine ◽  
Renal Diet ◽  
Prevalent Disease ◽  
The Impact

Chronic kidney disease (CKD) is a highly prevalent disease and common cause of morbidity and mortality in older cats. Early diagnosis and management of CKD is thought to be able to slow disease progression and impact positively on quality of life and longevity. Dietary management with a therapeutic renal diet is regarded as the mainstay of treatment for feline CKD from International Renal Interest Society stage 2 onwards. However, since the advent of markers such as symmetric dimethylarginine that have enabled clinicians to detect non-azotaemic CKD, there has been growing debate about how to best manage these patients. At this stage there are a limited number of studies investigating this. This article covers the current diagnostics used to identify renal disease. A second article looks at current understanding of therapeutic strategies and the impact this can have on progression of the disease, focusing on dietary management.

P0868ZONULIN AS A THERAPEUTIC POTENTIAL BIOMARKER OF ANEMIA IN PATIENTS WITH MULTIPLE MYELOMA AND CHRONIC KIDNEY DISEASE

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Karolina Woziwodzka ◽  
Jolanta Malyszko ◽  
Małgorzata Banaszkiewicz ◽  
Ewa Koc- Żorawska ◽  
Paulina Dumnicka ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Multiple Myeloma ◽  
Kidney Disease ◽  
Iron Status ◽  
P Value ◽  
Blood Collection ◽  
Serum Concentrations ◽  
Monoclonal Protein ◽  
Blood Hemoglobin ◽  
Potential Biomarker

Abstract Background and Aims Zonulin is a haptoglobin 2 precursor, that regulates the intestinal permeability. As a double-chain form it takes part in scavenging haemoglobin. Chronic inflammation is common complication of chronic kidney disease which affects iron metabolism. The most frequent manifestation of multiple myeloma is anaemia in up to 73% of patients. Serum concentrations of zonulin are associated with inflammation process, age, kidney failure and iron status and anaemia. The aim of the study was to analyse zonulin as a marker of anaemia in MM patients and investigate its relationship with acclaimed parameters of renal failure, inflammation, bone metabolism and stages of MM. Method The studied group of seventy-three patients with MM (67 symptomatic, 6 smoldering) included 35 women and 38 man, with mean age 69 ± 10 years. Median (IQR) of time from initial MM diagnosis was 36 (17; 69) months. Forty patients were in ISS stage 1, 15 in stage 2, and 12 in stage 3 at the time of blood collection. Remission of MM was diagnosed in 52 patients and stable or progressive disease in 21. Twenty-six patients had eGFR <60 ml/min/1.73 m2. The examined parameters included creatinine, urea, serum monoclonal protein, albumin, ferritin, blood hemoglobin and NT-proBNP. The association between zonulin, markers of MM stages and renal and bone markers were determined by the Pearson's test and multivariate stepwise regression analysis. The p-value <0.05 was considered statistically significant. Results Median (IQR) serum zonulin in the studied group was 23.9 (19.9; 27.4) ng/ml. There were no differences in zonulin concentrations between patients with smoldering versus symptomatic MM (p=0.4), with ISS 1 to 3 (p=0.7), with remission versus stable or progressive MM (p=0.9), or with eGFR <60 ml/min/1.73 m2 versus those with higher eGFR (p=0.6). Also, zonulin did not differ between subjects with and without anemia (Hb< the lower reference limit) (p=0.4). In whole studied group, significant correlations were observed between zonulin and serum albumin (R=0.30; p=0.009), creatinine (R=-0.28; p=0.018), eGFR (R=0.26; p=0.025), ferritin (R=0.34; p=0.013), NT-proBNP (R=-0.32; p=0.006). Moreover, in patients with symptomatic MM, zonulin correlated with monoclonal protein in serum (R=-0.29; p=0.046), blood hemoglobin (R=0.27; p=0.027), and age (R=-0.24; p=0.044). In multiple regression, serum concentrations of monoclonal protein (beta=-0.48 ± 0.16; p=0.006) and ferritin (beta=0.34 ± 0.14; p=0.023) as well as ISS stage 3 (beta=0.40 ± 0.18; p=0.034) were identified as independent predictors of zonulin concentrations. Conclusion Zonulin as a biomarker may promote diagnosis of etiology and management of MM-associated anaemia, which can contribute to biomarker-targeted therapeutic interventions. Early treatment may result in improved life expectancy in patients with MM and increase their quality of life.

scholarly journals Calcitonin Response to Naturally Occurring Ionized Hypercalcemia in Cats with Chronic Kidney Disease

2018 ◽  
Vol 32 (2) ◽  
pp. 727-735
Author(s):  
D.H.N. van den Broek ◽  
R.F. Geddes ◽  
T.L. Williams ◽  
Y.-M. Chang ◽  
J. Elliott ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Naturally Occurring

scholarly journals Renal ultrasonographic strain elastography and symmetric dimethylarginine (SDMA) in canine and feline chronic kidney disease

2020 ◽  
Vol 82 (8) ◽  
pp. 1104-1112
Author(s):  
Chutimon THANABOONNIPAT ◽  
Saikaew SUTAYATRAM ◽  
Chollada BURANAKARL ◽  
Nan CHOISUNIRACHON
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Symmetric Dimethylarginine ◽  
Strain Elastography
Sign in / Sign up

Export Citation Format

Share Document