scholarly journals Predictors of Sudden Cardiac Death in Doberman Pinschers with Dilated Cardiomyopathy

2016 ◽  
Vol 30 (3) ◽  
pp. 722-732 ◽  
Author(s):  
L. Klüser ◽  
P.J. Holler ◽  
J. Simak ◽  
G. Tater ◽  
P. Smets ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Dilated Cardiomyopathy ◽  
Cardiac Death ◽  
Doberman Pinschers

scholarly journals Sudden Cardiac Death in Hereditary Dilated Cardiomyopathy

2020 ◽  
Author(s):  
Marianna Leopoulou ◽  
Jo Ann LeQuang ◽  
Joseph V. Pergolizzi ◽  
Peter Magnusson
Keyword(s):  
Sudden Cardiac Death ◽  
Left Ventricle ◽  
Sudden Death ◽  
Risk Stratification ◽  
Dilated Cardiomyopathy ◽  
Cardiac Death ◽  
Disease Risk ◽  
Systolic Dysfunction ◽  
Preventive Strategies ◽  
Genetic Origin

Dilated cardiomyopathy (DCM) is characterized by the phenotype of a dilated left ventricle with systolic dysfunction. It is classified as hereditary when it is deemed of genetic origin; more than 50 genes are reported to be related to the condition. Symptoms include, among others, dyspnea, fatigue, arrhythmias, and syncope. Unfortunately, sudden cardiac death may be the first manifestation of the disease. Risk stratification regarding sudden death in hereditary DCM as well as preventive management poses a challenge due to the heterogeneity of the disease. The purpose of this chapter is to present the epidemiology, risk stratification, and preventive strategies of sudden cardiac death in hereditary DCM.

scholarly journals Orthotopic Heart Transplantation in a Patient With Gitelman Syndrome and Dilated Cardiomyopathy

2020 ◽  
Vol 11 (4) ◽  
pp. 520-521 ◽  
Author(s):  
Shannon Alexandra Solt ◽  
Timothy M. Hoffman ◽  
Mahesh S. Sharma ◽  
Katherine D. Westreich ◽  
Margaret Kihlstrom ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Heart Transplantation ◽  
Dilated Cardiomyopathy ◽  
Cardiac Death ◽  
Distal Tubule ◽  
Gitelman Syndrome ◽  
Orthotopic Heart Transplantation ◽  
Benign Condition ◽  
Electrolyte Disturbances

Gitelman syndrome (GS) is a rare hereditary tubulopathy affecting the distal tubule leading to significant electrolyte disturbances.1 Although generally a benign condition, rare associations with arrhythmias and sudden cardiac death have been reported.1 A paucity of literature exists associating GS with cardiomyopathy. We present a child with dilated cardiomyopathy and GS who was successfully treated with orthotopic heart transplantation.

scholarly journals Risk stratification and subclinical phenotyping of dilated and/or arrhythmogenic cardiomyopathy mutation-positive relatives: CVON eDETECT consortium

2021 ◽  
Author(s):  
R. W. Roudijk ◽  
K. Taha ◽  
M. Bourfiss ◽  
P. Loh ◽  
L. van den Heuvel ◽  
...  
Keyword(s):  
Heart Failure ◽  
Sudden Cardiac Death ◽  
Early Detection ◽  
Risk Stratification ◽  
Dilated Cardiomyopathy ◽  
Cardiac Death ◽  
Diagnostic Techniques ◽  
Arrhythmogenic Cardiomyopathy ◽  
Early Detection Of Disease ◽  
Non Invasive

AbstractIn relatives of index patients with dilated cardiomyopathy and arrhythmogenic cardiomyopathy, early detection of disease onset is essential to prevent sudden cardiac death and facilitate early treatment of heart failure. However, the optimal screening interval and combination of diagnostic techniques are unknown. The clinical course of disease in index patients and their relatives is variable due to incomplete and age-dependent penetrance. Several biomarkers, electrocardiographic and imaging (echocardiographic deformation imaging and cardiac magnetic resonance imaging) techniques are promising non-invasive methods for detection of subclinical cardiomyopathy. However, these techniques need optimisation and integration into clinical practice. Furthermore, determining the optimal interval and intensity of cascade screening may require a personalised approach. To address this, the CVON-eDETECT (early detection of disease in cardiomyopathy mutation carriers) consortium aims to integrate electronic health record data from long-term follow-up, diagnostic data sets, tissue and plasma samples in a multidisciplinary biobank environment to provide personalised risk stratification for heart failure and sudden cardiac death. Adequate risk stratification may lead to personalised screening, treatment and optimal timing of implantable cardioverter defibrillator implantation. In this article, we describe non-invasive diagnostic techniques used for detection of subclinical disease in relatives of index patients with dilated cardiomyopathy and arrhythmogenic cardiomyopathy.

Genetics of Dilated Cardiomyopathy: Risk of Conduction Defects and Sudden Cardiac Death

2010 ◽  
Vol 2 (4) ◽  
pp. 599-609
Author(s):  
Samer Arnous ◽  
Petros Syrris ◽  
Srijita Sen-Chowdhry ◽  
William J. McKenna
Keyword(s):  
Sudden Cardiac Death ◽  
Dilated Cardiomyopathy ◽  
Cardiac Death
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