scholarly journals Disease Associated with Equine Coronavirus Infection and High Case Fatality Rate

2014 ◽  
Vol 29 (1) ◽  
pp. 307-310 ◽  
Author(s):  
C.L. Fielding ◽  
J.K. Higgins ◽  
J.C. Higgins ◽  
S. McIntosh ◽  
E. Scott ◽  
...  
Keyword(s):  
Case Fatality Rate ◽  
Case Fatality ◽  
Fatality Rate ◽  
High Case Fatality Rate ◽  
Coronavirus Infection

scholarly journals Crimean-Congo hemorrhagic fever-induced liver injury: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Sawai Singh Rathore ◽  
Ade Harrison Manju ◽  
Qingqing Wen ◽  
Manush Sondhi ◽  
Reshma Pydi ◽  
...  
Keyword(s):  
Liver Injury ◽  
Case Fatality Rate ◽  
Meta Analysis ◽  
Case Series ◽  
Case Fatality ◽  
Hemorrhagic Fever ◽  
Fatality Rate ◽  
High Case Fatality Rate ◽  
Crimean Congo Hemorrhagic Fever ◽  
Pooled Prevalence

Background: Crimean-Congo hemorrhagic fever (CCHF) is a fatal acute tick-borne viral infection and a substantial emerging global public health threat. This illness has a high case fatality rate of up to 40%. The liver is one of the important target organs of the CCHF virus. Objective: The aim of this meta-analysis to evaluate the correlation between CCHF  and liver injury and draw more generalized inferences about the abnormal serum markers of liver injury such as alanine aminotransferase (ALT), aspartate aminotransferase (AST) in CCHF patients. Methods: A literature search was accomplished for published eligible articles with MEDLINE/PubMed and Embase databases. All eligible observational studies and case series were included from around the world. The inclusion criteria were articles describing liver injury biomarkers AST and ALT amongst patients diagnosed with CCHF. Results: Data from 18 studies, consisting of 1238 patients with CCHF  were included in this meta-analysis. The overall pooled prevalence of at least one raised liver injury biomarker was 77.95% (95% CI, I2 = 88.50%, p < 0.0001). Similarly, pooled prevalence of elevated AST and ALT was 85.92% (95% CI, I2 = 85.27%,  p < 0.0001) and 64.30% (95% CI, I2 = 88.32%,  p < 0.0001) respectively.  Both Egger and Begg-Mazumdar’s tests detected no apparent publication bias in all three meta-analyses(p > 0.05).  Conclusion: These elevated liver injury biomarkers have been identified as significant prognostic factors. Hence, Physicians must recognize and continuously monitor these biomarkers, since these aid early stratification of prognosis and the prevention of severe outcomes in infection with such a high case fatality rate.

scholarly journals COVID-19 in Sudan

2021 ◽  
Vol 15 (02) ◽  
pp. 204-208
Author(s):  
Ayman Ahmed ◽  
Nouh Saad Mohamed ◽  
Sarah Misbah EL-Sadig ◽  
Lamis Ahmed Fahal ◽  
Ziad Bakri Abelrahim ◽  
...  
Keyword(s):  
Health Systems ◽  
Case Fatality Rate ◽  
Case Fatality ◽  
Control Measures ◽  
Religious Practices ◽  
Mass Gathering ◽  
Fatality Rate ◽  
High Case Fatality Rate ◽  
The Government ◽  
And Control

The steadily growing COVID-19 pandemic is challenging health systems worldwide including Sudan. In Sudan, the first COVID-19 case was reported on 13th March 2020, and up to 11 November 2020 there were 14,401 confirmed cases of which 9,535 cases recovered and the rest 3,750 cases were under treatment. Additionally, 1,116 deaths were reported, indicating a relatively high case fatality rate of 7.7%. Several preventive and control measures were implemented by the government of Sudan and health partners, including the partial lockdown of the country, promoting social distancing, and suspending mass gathering such as festivals and performing religious practices in groups. However, new cases still emerging every day and this could be attributed to the noncompliance of the individuals to the advocated preventive measurements.

Subway-Related Trauma: An Urban Public Health Issue with a High Case-Fatality Rate

2018 ◽  
Vol 55 (2) ◽  
pp. 165-171.e1 ◽  
Author(s):  
Simon G. Rodier ◽  
Charles J. DiMaggio ◽  
Stephen Wall ◽  
Vasiliy Sim ◽  
Spiros G. Frangos ◽  
...  
Keyword(s):  
Public Health ◽  
Case Fatality Rate ◽  
Case Fatality ◽  
Health Issue ◽  
Public Health Issue ◽  
Fatality Rate ◽  
High Case Fatality Rate

scholarly journals Aortic valve endocarditis with Erysipelothrix rhusiopathiae: A rare zoonosis

2018 ◽  
Vol 10 (3) ◽  
Author(s):  
Jenny Jónsdóttir Nielsen ◽  
Bjørn Blomberg ◽  
Shahin Gaïni ◽  
Steinar Lundemoen
Keyword(s):  
Aortic Valve ◽  
Case Fatality Rate ◽  
Case Fatality ◽  
Animal Husbandry ◽  
Skin Infections ◽  
Fatality Rate ◽  
Erysipelothrix Rhusiopathiae ◽  
High Case Fatality Rate ◽  
Exposed Skin ◽  
Spare Time

Erysipelothrix rhusiopathiae has an economic impact in animal husbandry by causing infection in swine, sheep and poultry. E. rhusiopathiae is present in the surface mucoid slime on fish, although fishes do not seem to be affected. Humans can get infected, maost often through occupational exposure and may suffer typical erysipeloid infection on exposed skin such as on hands and fingers, or deeper skin infections, and sometimes sepsis and endocarditis, associated with high case-fatality rate. We describe a case of aortic valve endocarditis caused by E. rhusiopathiae in a 59-year-old man who enjoyed fishing in his spare time.

Neonatal Candida parapsilosis outbreak with a high case fatality rate

1995 ◽  
Vol 14 (9) ◽  
pp. 776-781 ◽  
Author(s):  
HARRI SAXEN ◽  
MARTTI VIRTANEN ◽  
PETTERI CARLSON ◽  
KALLE HOPPU ◽  
MAIJA POHJAVUORI ◽  
...  
Keyword(s):  
Case Fatality Rate ◽  
Candida Parapsilosis ◽  
Case Fatality ◽  
Fatality Rate ◽  
High Case Fatality Rate

scholarly journals Invasive meningococcal disease associated with a very high case fatality rate in the North-West of Poland

2006 ◽  
Vol 46 (2) ◽  
pp. 230-235 ◽  
Author(s):  
Anna SkoczyÅ„ska ◽  
Marcin KadÅ‚ubowski ◽  
Józef Knap ◽  
Maria Szulc ◽  
Marzena Janusz-Jurczyk ◽  
...  
Keyword(s):  
Meningococcal Disease ◽  
Case Fatality Rate ◽  
Case Fatality ◽  
Invasive Meningococcal Disease ◽  
Fatality Rate ◽  
High Case Fatality Rate ◽  
North West ◽  
The North ◽  
Very High

scholarly journals Diphtheria in Hull: A Review of six years bacteriological typing

1945 ◽  
Vol 44 (3) ◽  
pp. 184-192
Author(s):  
H. Mason Leete
Keyword(s):  
Case Fatality Rate ◽  
Case Fatality ◽  
Great Majority ◽  
Consecutive Series ◽  
City Hospital ◽  
Fatality Rate ◽  
High Case Fatality Rate ◽  
Clinical Cases

This paper embodies the findings in all proven cases of diphtheria admitted to the Hull City Hospital during the years 1938–43 inclusive. All cases during those 6 years were typed and the clinical and bacteriological findings correlated. Since 1932 all severe cases had been typed and in the winter of 1932–3 a consecutive series of 313 cases was investigated and the results published (Leete, McLeod & Morrison, 1933). The 1933 paper showed a high gravis incidence of 59% and an associated high case fatality rate. Not until the end of 1937 was it again possible to type every case admitted but since then we have done so, and the series now presented embodies observations on 2039 infections, the great majority of which were clinical cases.

scholarly journals Therapeutic effects of favipiravir against severe fever with thrombocytopenia syndrome virus infection in a lethal mouse model: dose-efficacy studies upon oral administration

2018 ◽  
Author(s):  
Hideki Tani ◽  
Takashi Komeno ◽  
Aiko Fukuma ◽  
Shuetsu Fukushi ◽  
Satoshi Taniguchi ◽  
...  
Keyword(s):  
Body Weight ◽  
Mouse Model ◽  
Oral Administration ◽  
Post Infection ◽  
Case Fatality Rate ◽  
Case Fatality ◽  
Type I ◽  
Fatality Rate ◽  
High Case Fatality Rate ◽  
Severe Fever

AbstractBackgroundSevere fever with thrombocytopenia syndrome (SFTS), caused by SFTS virus (SFTSV), is a viral hemorrhagic fever with a high case fatality rate. Favipiravir was reported to be effective in the treatment of SFTSV infection in vivo in type I interferon receptor knockout (IFNAR-/-) mice at treatment dosages of both 60 mg/kg/day and 300 mg/kg/day for a duration of 5 days.MethodsIn this study, the efficacy of favipiravir at dosages of 120 mg/kg/day and 200 mg/kg/day against SFTSV infection in an IFNAR-/- mouse infection model was investigated. IFNAR-/- mice were subcutaneously infected with SFTSV at a 1.0 × 106 50% tissue culture infectious dose followed by twice daily administration of favipiravir, comprising a total dose of either 120 mg/kg/day or 200 mg/kg/day. The treatment was initiated either immediately post infection or at predesignated time points post infection.ResultsAll mice treated with favipiravir at dosages of 120 mg/kg/day or 200 mg/kg/day survived when the treatment was initiated at no later than 4 days post infection. A decrease in body weight of mice was observed when the treatment was initiated at 3–4 days post infection. Furthermore, all control mice died. The body weight of mice did not decrease when treatment with favipiravir was initiated immediately post infection at dosages of 120 mg/kg/day and 200 mg/kg/day.ConclusionsSimilar to the literature-reported peritoneal administration of favipiravir at 300 mg/kg/day, the oral administration of favipiravir at dosages of 120 mg/kg/day and 200 mg/kg/day to IFNAR-/- mice infected with SFTSV was effective.Author summarySevere fever with thrombocytopenia syndrome (SFTS), which is caused by SFTS virus (SFTSV), is a generalized infectious disease with a high case fatality rate. Currently, no effective therapeutics for SFTS is available; therefore, the development of effective antiviral drugs is needed. Favipiravir exhibits antiviral activity against various RNA viruses, including SFTSV. The present study demonstrated the efficacy of favipiravir in the treatment of SFTSV infection in a lethal mouse model, when the dose was set similar to that approved for anti-influenza drug in humans by the Ministry of Health, Labour and Welfare, Japan. The present study suggests that favipiravir is a promising drug for the treatment of SFTSV infection.

scholarly journals Is there room for improving case management for contacts of meningococcal disease in the European Union?

2008 ◽  
Vol 13 (10) ◽  
pp. 1-2 ◽  
Author(s):  
P L Lopalco
Keyword(s):  
European Union ◽  
Meningococcal Disease ◽  
Case Fatality Rate ◽  
Case Fatality ◽  
Severe Illness ◽  
Fatality Rate ◽  
The European Union ◽  
High Case Fatality Rate ◽  
Children And Young Adults ◽  
Loss Of Limbs

Invasive meningococcal disease (IMD) is a severe illness primarily affecting children and young adults. It has a high case fatality rate (10%-14%) and 11%-19% of patients who recover experience permanent hearing loss, mental retardation, loss of limbs or other serious sequelae.

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