scholarly journals Plasma Cardiac Troponin I Concentration and Cardiac Death in Cats with Hypertrophic Cardiomyopathy

2014 ◽  
Vol 28 (6) ◽  
pp. 1731-1737 ◽  
Author(s):  
K. Borgeat ◽  
K. Sherwood ◽  
J.R. Payne ◽  
V. Luis Fuentes ◽  
D.J. Connolly
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Cardiac Troponin ◽  
Cardiac Death ◽  
Troponin I ◽  
Cardiac Troponin I

scholarly journals Diagnostic Application of Postmortem Cardiac Troponin I Pericardial Fluid/Serum Ratio in Sudden Cardiac Death

Diagnostics ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 614
Author(s):  
Diana Hernández-Romero ◽  
María del Rocío Valverde-Vázquez ◽  
Juan Pedro Hernández del Rincón ◽  
José A. Noguera-Velasco ◽  
María D. Pérez-Cárceles ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Sudden Cardiac Death ◽  
Cardiac Troponin ◽  
Cardiac Death ◽  
Troponin I ◽  
Sampling Site ◽  
Pericardial Fluid ◽  
Cardiac Troponin I ◽  
Control Group ◽  
Complementary Method

In approximately 5% of unexpected deaths, establishing a conclusive diagnosis exclusively on the basis of anatomo-pathological findings in a classic autopsy is difficult. Postmortem biomarkers have been actively investigated as complementary indicators to help to reach valid conclusions about the circumstances of death. Several studies propose either the pericardial fluid or peripheral veins as a location for troponin determination, but the optimum sampling site is still a matter of debate. Our objective was to evaluate the association between the ratio of troponin values in the pericardial fluid and serum (determined postmortem) and the diagnosis of acute myocardial infarction (AMI) in the context of sudden cardiac death. We included 175 forensic cases. Two groups were established: AMI deaths (48; 27.4%) and the control group (127; 72.6%). The cardiac Troponin I (cTnI) values in the pericardial fluid and the troponin ratio were found to be associated with the cause of death. Univariate regression analyses showed that both age and the cTnI ratio were significantly associated with the diagnosis of AMI death. In a multivariate analysis, adjusting for confounding factors, the age and cTnI ratio were independent predictors of death from myocardial infarction. We performed a receiver operating characteristic (ROC) curve for the cTnI ratio for AMI death and selected a cut-off point. Our biomarker was found to be a valuable and highly effective tool for use in the forensic field as a complementary method to facilitate diagnosis in nonconclusive autopsies.

scholarly journals Transgenic Modeling of a Cardiac Troponin I Mutation Linked to Familial Hypertrophic Cardiomyopathy

2000 ◽  
Vol 87 (9) ◽  
pp. 805-811 ◽  
Author(s):  
Jeanne James ◽  
Yan Zhang ◽  
Hanna Osinska ◽  
Atsushi Sanbe ◽  
Raisa Klevitsky ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Cardiac Troponin I ◽  
Familial Hypertrophic Cardiomyopathy

Functional Consequences of the Mutations in Human Cardiac Troponin I Gene Found in Familial Hypertrophic Cardiomyopathy

2001 ◽  
Vol 33 (12) ◽  
pp. 2095-2107 ◽  
Author(s):  
Fumi Takahashi-Yanaga ◽  
Sachio Morimoto ◽  
Keita Harada ◽  
Reiko Minakami ◽  
Fumie Shiraishi ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Cardiac Troponin I ◽  
Familial Hypertrophic Cardiomyopathy ◽  
Functional Consequences ◽  
I Gene

Molecular insights from a novel cardiac troponin I mouse model of familial hypertrophic cardiomyopathy

2006 ◽  
Vol 41 (4) ◽  
pp. 623-632 ◽  
Author(s):  
Tatiana Tsoutsman ◽  
Jessica Chung ◽  
Alessandra Doolan ◽  
Lan Nguyen ◽  
Iwan A. Williams ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Mouse Model ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Cardiac Troponin I ◽  
Familial Hypertrophic Cardiomyopathy

scholarly journals Functional Consequences of the Human Cardiac Troponin I Hypertrophic Cardiomyopathy Mutation R145G in Transgenic Mice

2008 ◽  
Vol 283 (29) ◽  
pp. 20484-20494 ◽  
Author(s):  
Yuhui Wen ◽  
Jose Renato Pinto ◽  
Aldrin V. Gomes ◽  
Yuanyuan Xu ◽  
Yingcai Wang ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Transgenic Mice ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Cardiac Troponin I ◽  
Functional Consequences

scholarly journals Heterogeneity of Clinical Manifestation of Hypertrophic Cardiomyopathy Caused by Deletion of Lysine 183 in Cardiac Troponin I Gene

2010 ◽  
Vol 51 (3) ◽  
pp. 214-217 ◽  
Author(s):  
Akira Funada ◽  
Eiichi Masuta ◽  
Noboru Fujino ◽  
Kenshi Hayashi ◽  
Hidekazu Ino ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Clinical Manifestation ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Cardiac Troponin I ◽  
I Gene
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