scholarly journals Detection of Clinically Relevant Pain Relief in Cats with Degenerative Joint Disease Associated Pain

2014 ◽  
Vol 28 (2) ◽  
pp. 346-350 ◽  
Author(s):  
M.E. Gruen ◽  
E. Griffith ◽  
A. Thomson ◽  
W. Simpson ◽  
B.D.X. Lascelles
Keyword(s):  
Pain Relief ◽  
Degenerative Joint Disease ◽  
Joint Disease

scholarly journals Bioregulatory drugs in osteoarthritis management

2019 ◽  
pp. 76-83
Author(s):  
O. A. Shavlovskaya
Keyword(s):  
Chronic Pain ◽  
Pain Relief ◽  
Combined Treatment ◽  
Pain Syndrome ◽  
Cartilage Destruction ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Functional Improvement ◽  
Chronic Pain Syndrome ◽  
Matrix Loss

Osteoarthritis (OA) is a degenerative joint disease. Modern theories consider various structural (cartilage destruction) and biophysical disorders (matrix loss of glycosaminoglycans) as the basis of acute and chronic pain syndrome. The main aim of OA therapy is pain relief and functional improvement. To manage pain syndrome in OA it is reasonable to use complex bioregulatory drugs (CBD) (Traumeel S, Zeel T, Discus compositum) both in monotherapy and in combined treatment. The effectiveness of CBD is comparable to that of NSAIDs and CS.

Anticoagulant Therapy for the Treatment of Idiopathic Osteonecrosis.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 919-919
Author(s):  
Saaib Al Shehadat ◽  
Gregory R. Bociek ◽  
William Haire
Keyword(s):  
Pain Relief ◽  
Anticoagulant Therapy ◽  
Surgical Intervention ◽  
Motor Vehicle ◽  
Venous Pressure ◽  
Anticoagulation Therapy ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Severe Toxicity ◽  
Orthopedic Surgeon

Abstract Background: Studies suggest that thrombosis may play an important etiologic role in adults with idiopathic osteonecrosis. Thrombotic occlusion in the bone leads to increased intraosseus venous pressure, reduced arterial flow, and ultimately hypoxic bone death. Total joint arthroplasty is the standard treatment for advanced osteonecrosis. The majority of untreated patients with idiopathic osteonecrosis will progress to significant degenerative disease. We report our experience in five consecutive patients who were referred to our institute and were treated with anticoagulant therapy instead of surgical intervention. Methods: Five adult patients (median age 38 years old, range 28–49 years) were evaluated first by an orthopedic surgeon for knee or hip pain. The diagnosis of osteonecrosis was confirmed by Magnetic Resonance Image (MRI) interpreted in all cases by both a radiologist and an orthopedic surgeon. Osteonecrosis was designated as idiopathic after eliminating other known associated factors, mainly drugs (glucocorticoids) or diseases (alcoholism, sickle cell disease). The response to treatment was measured by pain relief, bone imaging stability or improvement, and subsequent need for surgical intervention. Treatment was discontinued if the patient developed severe toxicity or disease progression requiring surgical intervention. Four patients were treated with warfarin with a target international normalized ratio (INR) of 2–3, while one patient was treated with enoxaparin (1 mg/kg twice a day). Patients were followed up every three months by both a hematologist and an orthopedic surgeon, and MRI evaluation was performed at three month intervals for one year or when symptoms worsened. After achieving pain relief and stability of lesions on MRI, patients were given the choice of discontinuing the treatment. Results: Three out of four patients on warfarin and the patient on enoxaparin had pain improvement within three months of initiating therapy. All patients reported a reduction of pain at a median of 7.5 months (6–9 months). MRI revealed disease stability in those patients within three months, and some radiographic signs of improvement at 9 months. Complete resolution of imaging abnormalities was seen in 5 years in one patient. Patients tolerated the therapy well without any major toxicity and decided to continue the anticoagulation therapy. One patient preferred to discontinue therapy after 4.5 years, and continued to be asymptomatic 10 months later. The fifth patient had bilateral distal femoral and proximal tibial osteonecrosis. The patient had severe degenerative joint disease involving the right knee from previous motor vehicle accident. The patient eventually underwent right knee arthroplasty for severe pain, and the microscopic examination of the bone and debridement tissue from the joint replacement procedure showed focal avascular necrosis and features of degenerative joint disease. The patient resumed the warfarin therapy postoperatively with stability of imaging abnormalities on the left side after 3.5 years of continuous therapy. Warfarin was replaced by aspirin with eighteen months of follow up, the patient continued to be asymptomatic with stable imaging abnormalities of the left leg. Conclusion: The findings suggest that anticoagulation therapy may benefit patients with early stage of idiopathic osteonecrosis, and may delay or eliminate the need for surgical intervention. Further studies are warranted in he future to compare different anticoagulants with placebo.

scholarly journals Treatment and Prevention of Osteoarthritis through Exercise and Sports

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Victor Valderrabano ◽  
Christina Steiger
Keyword(s):  
Pain Relief ◽  
Muscle Function ◽  
Symptomatic Treatment ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Joint Function ◽  
Treatment And Prevention ◽  
High Prevalence ◽  
Strengthening Exercises ◽  
Prevention And Treatment

Osteoarthritis (OA) is a degenerative joint disease with a high prevalence among older people. To date, the pathogenesis of the disease and the link between muscle function and OA is not entirely understood. As there is no known cure for OA, current research focuses on prevention and symptomatic treatment of the disorder. Recent research has indicated that muscle weakness precedes the onset of OA symptoms. Furthermore, several studies show a beneficial effect of land-based aerobic and strengthening exercises on pain relief and joint function. Therefore, current research focuses on the possibility to employ exercise and sports in the prevention and treatment of OA.

Apportionment of Impairment from Meniscal Tears and Knee Arthritis

2013 ◽  
Vol 18 (5) ◽  
pp. 1-10 ◽  
Author(s):  
Charles N. Brooks ◽  
James B. Talmage
Keyword(s):  
Medial Meniscus ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Detailed Knowledge ◽  
Meniscal Tears ◽  
Knee Arthritis ◽  
Degenerative Arthritis ◽  
Study Results ◽  
Physical Findings ◽  
Causation Analysis

Abstract Meniscal tears and osteoarthritis (osteoarthrosis, degenerative arthritis, or degenerative joint disease) are two of the most common conditions involving the knee. This article includes definitions of apportionment and causes; presents a case report of initial and recurrent tears of the medial meniscus plus osteoarthritis (OA) in the medial compartment of the knee; and addresses questions regarding apportionment. The authors, experienced impairment raters who are knowledgeable regarding the AMA Guides to the Evaluation of Permanent Impairment (AMA Guides), show that, when instructions on impairment rating are incomplete, unclear, or inconsistent, interrater reliability diminishes (different physicians may derive different impairment estimates). Accurate apportionment of impairment is a demanding task that requires detailed knowledge of causation for the conditions in question; the mechanisms of injury or extent of exposures; prior and current symptoms, functional status, physical findings, and clinical study results; and use of the appropriate edition of the AMA Guides. Sometimes the available data are incomplete, requiring the rating physician to make assumptions. However, if those assumptions are reasonable and consistent with the medical literature and facts of the case, if the causation analysis is plausible, and if the examiner follows impairment rating instructions in the AMA Guides (or at least uses a rational and hence defensible method when instructions are suboptimal), the resulting apportionment should be credible.

3. Degenerative joint disease

2000 ◽  
Vol 81 (3B) ◽  
pp. s67-s72
Author(s):  
Victoria A. Brander ◽  
Darryl L. Kaelin ◽  
Terry H. Oh ◽  
Peter A.C. Lim
Keyword(s):  
Degenerative Joint Disease ◽  
Joint Disease

Osteotomy for Correction of Premature Growth Plate Closure in 24 Dogs

1994 ◽  
Vol 07 (03) ◽  
pp. 129-135 ◽  
Author(s):  
C.W. Miller ◽  
P.W. Morgan
Keyword(s):  
Corrective Osteotomy ◽  
Functional Results ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Angular Deformity ◽  
Dynamic Correction ◽  
Age At Surgery ◽  
Limb Deformities ◽  
The Mean ◽  
A Prospective Study

SummaryTwenty-four dogs (27 limbs) were evaluated after surgery for correction of forelimb angular limb deformities. Partial ulnar ostectomies or definitive corrective osteotomies were performed depending upon the age of the dog. According to owner assessment nine of fourteen limbs were considered functionally good, or excellent, after partial ulnar ostectomies. Younger dogs appeared to have better functional results after dynamic correction with the mean age at surgery of dogs with good to excellent results being 6.5 months contrasted to the mean age at surgery of dogs with fair to poor results being 9.75 months. Ten of fourteen limbs were considered functionally good or excellent after definitive corrective osteotomy. One dog had definitive osteotomy after partial ulnar ostectomy in order to further correct a residual angular deformity. However, 58% of the limbs with radiographic follow-up had signs of degenerative joint disease (DJD). There were not significant differences between neither degree of angulation remaining after surgery and the functional result nor the degree of angulation remaining after surgery and the development of DJD. A prospective study is warranted to more objectively assess the efficacy of surgical correction of angular limb deformities in dogs.Twenty-four dogs were evaluated after surgery for correction of forelimb angular limb deformities. The results are described.

Anticoagulant Properties of Three Mucopolysaccharides Used in Rheumatology

1983 ◽  
Vol 50 (03) ◽  
pp. 652-655 ◽  
Author(s):  
F Bauer ◽  
P Schulz ◽  
G Reber ◽  
C A Bouvier
Keyword(s):  
Factor Xa ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Thrombin Time ◽  
Coagulation Tests ◽  
Amplification System ◽  
Relative Potencies ◽  
In Vivo Administration

SummaryThree mucopolysaccharides (MPS) used in the treatment of degenerative joint disease were compared to heparin to establish their relative potencies on 3 coagulation tests, the aPTT, the antifactor X a activity and the dilute thrombin time. One of the compounds, Arteparon®, was one fourth as potent as heparin on the aPTT, but had little or no influence on the 2 other tests. Further in vitro studies suggested that Arteparon® acted at a higher level than factor Xa generation in the intrinsic amplification system and that its effect was independent of antithrombin III. In vivo administration of Arteparon® confirmed its anticoagulant properties, which raises the question of the clinical use of this MPS.

The Gut Microbiota of Rats under Experimental Osteoarthritis and Administration of Chondroitin Sulfate and Probiotic

2020 ◽  
Vol 82 (6) ◽  
pp. 64-73
Author(s):  
O.H. Korotkyi ◽  
◽  
T.V. Luhovska ◽  
T.M. Serhiychuk ◽  
K.O. Dvorshchenko ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Chondroitin Sulfate ◽  
Joint Inflammation ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Quantitative Composition ◽  
Combined Administration ◽  
Osteoarthritis Progression ◽  
Experimental Osteoarthritis ◽  
Gut Microbiota Composition

Osteoarthritis is a most widespread chronic degenerative joint disease that causes pain, cartilage deformation, and joint inflammation. Adverse alterations of intestinal microbiota like dysbiosis may lead to metabolic syndrome and inflammation, two important components of osteoarthritis progression. Aim. In this study we investigated the effect of chondroitin sulfate and probiotics on the gut microbiome in monoiodoacetate-induced osteoarthritis model in rats. Methods. The species and quantitative composition of feces were determined using diagnostic media with selective properties. Further identification of isolated microorganisms was carried out according to morphological, tinctorial, physiological and metabolic parameters. The results are presented in the form of lg CFU/g. Results. Induction of osteoarthritis caused significant increasing the number of opportunistic enterobacteria and lactose-negative Escherichia coli against the decreasing of lacto- and bifidobacteria that may indicate a dysbiotic condition. Coadministration of chondroitin sulfate and probiotic bacteria has led to improvement the quantitative composition of the gut microbiota in experimental animals, the numerous of Bifidobacterium, Lactobacillus were increasing against decreasing the quantitative composition of opportunistic microorganisms. Conclusions. Monoiodoacetate-induced osteoarthritis caused dysbiosis of gut in rat. We observed beneficial effect of combined administration of chondroitin sulfate and probiotics on gut microbiota composition in rats with experimental osteoarthritis. Thus, adding of supplements like probiotics to standard treatment of osteoarthritis may have potentials to prevent and treat this disease.

Allogenic Mesenchymal Stem Cells as a Treatment for Equine Degenerative Joint Disease: A Pilot Study

2014 ◽  
Vol 9 (6) ◽  
pp. 497-503 ◽  
Author(s):  
Sarah Broeckx ◽  
Marc Suls ◽  
Charlotte Beerts ◽  
Aurelie Vandenberghe ◽  
Bert Seys ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Pilot Study ◽  
Degenerative Joint Disease ◽  
Joint Disease
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