The Seroprevalence of Canine Influenza Virus H3N8 in Dogs Participating in a Flyball Tournament in Pennsylvania in 2010: A Follow-Up Study

2013 ◽  
Vol 27 (2) ◽  
pp. 367-370 ◽  
Author(s):  
C.A. Wiley ◽  
M.C. Ottoson ◽  
M.M. Garcia ◽  
L.E. Wiley ◽  
C.M. Otto
Keyword(s):  
Influenza Virus ◽  
Canine Influenza Virus ◽  
Follow Up Study ◽  
Canine Influenza

scholarly journals The follow-up study of swine and Hong Kong influenza virus infection among Japanese hogs.

1982 ◽  
Vol 136 (4) ◽  
pp. 353-358 ◽  
Author(s):  
JIRO ARIKAWA ◽  
NOBUHISA YAMANE ◽  
KIYOSHI TOTSUKAWA ◽  
NAKAO ISHIDA
Keyword(s):  
Influenza Virus ◽  
Hong Kong ◽  
Virus Infection ◽  
Influenza Virus Infection ◽  
Follow Up Study

scholarly journals Canine Influenza Virus is Mildly Restricted by Canine Tetherin Protein

Viruses ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 565
Author(s):  
Yun Zheng ◽  
Xiangqi Hao ◽  
Qingxu Zheng ◽  
Xi Lin ◽  
Xin Zhang ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Transmembrane Domain ◽  
Transmembrane Protein ◽  
Cellular Damage ◽  
Interferon Response ◽  
Type I ◽  
Canine Influenza Virus ◽  
Immune Factor ◽  
Canine Influenza ◽  
The Impact

Tetherin (BST2/CD317/HM1.24) has emerged as a key host-cell ·defence molecule that acts by inhibiting the release and spread of diverse enveloped virions from infected cells. We analysed the biological features of canine tetherin and found it to be an unstable hydrophilic type I transmembrane protein with one transmembrane domain, no signal peptide, and multiple glycosylation and phosphorylation sites. Furthermore, the tissue expression profile of canine tetherin revealed that it was particularly abundant in immune organs. The canine tetherin gene contains an interferon response element sequence that can be regulated and expressed by canine IFN-α. A CCK-8 assay showed that canine tetherin was effective in helping mitigate cellular damage caused by canine influenza virus (CIV) infection. Additionally, we found that the overexpression of canine tetherin inhibited replication of the CIV and that interference with the canine tetherin gene enhanced CIV replication in cells. The impact of canine tetherin on CIV replication was mild. However, these results elucidate the role of the innate immune factor, canine tetherin, during CIV infection for the first time.

scholarly journals In VitroSusceptibility of Canine Influenza A (H3N8) Virus to Nitazoxanide and Tizoxanide

2010 ◽  
Vol 2010 ◽  
pp. 1-5 ◽  
Author(s):  
Laura V. Ashton ◽  
Robert L. Callan ◽  
Sangeeta Rao ◽  
Gabriele A. Landolt
Keyword(s):  
Influenza Virus ◽  
Influenza A ◽  
The United States ◽  
Canine Influenza Virus ◽  
Valuable Adjunct ◽  
Canine Influenza ◽  
The Impact ◽  
H3n8 Virus

Infection of dogs with canine influenza virus (CIV) is considered widespread throughout the United States following the first isolation of CIV in 2004. While vaccination against influenza A infection is a common and important practice for disease control, antiviral therapy can serve as a valuable adjunct in controlling the impact of the disease. In this study, we examined the antiviral activity of nitazoxanide (NTZ) and tizoxanide (TIZ) against three CIV isolatesin vitro. NTZ and TIZ inhibited virus replication of all CIVs with 50% and 90% inhibitory concentrations ranging from 0.17 to 0.21 μMand from 0.60 to 0.76 μM, respectively. These results suggest that NTZ and TIZ are effective against CIV and may be useful for treatment of canine influenza in dogs but further investigation of thein vivoefficacy against CIV as well as the drug's potential for toxicity in dogs is needed.

scholarly journals Evolution of the hemagglutinin gene of H3N8 canine influenza virus in dogs

Virus Genes ◽  
2014 ◽  
Vol 49 (3) ◽  
pp. 393-399 ◽  
Author(s):  
Heidi L. Pecoraro ◽  
Susi Bennett ◽  
Miranda E. Spindel ◽  
Gabriele A. Landolt
Keyword(s):  
Influenza Virus ◽  
Canine Influenza Virus ◽  
Hemagglutinin Gene ◽  
Canine Influenza

scholarly journals Role of CARD Region of MDA5 Gene in Canine Influenza Virus Infection

Viruses ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 307 ◽  
Author(s):  
Cheng Fu ◽  
Shaotang Ye ◽  
Yongbo Liu ◽  
Shoujun Li
Keyword(s):  
Innate Immunity ◽  
Influenza Virus ◽  
Cytokine Production ◽  
Influenza Virus Infection ◽  
Luciferase Assay ◽  
Canine Influenza Virus ◽  
Card Domain ◽  
Canine Influenza ◽  
Receptor Family

MDA5 belongs to the RIG-I-like receptor family, which is involved in innate immunity. During viral infection, MDA5 generates an antiviral response by recognizing the ligand to activate interferon. However, the role and mechanism of MDA5 in canine influenza virus (CIV) infection are unclear. To understand the mechanism of canine MDA5-mediated innate immunity during CIV infection, we detected the distribution of MDA5 in beagles, and the structural prediction showed that MDA5 was mainly composed of a CARD domain, RD domain, and DExD/H helix structure. Moreover, we found that MDA5 inhibits CIV replication. Furthermore, in the dual luciferase assay, we revealed that the CARD region of MDA5 strongly activated the IFN-β promoter and mainly transmitted signals through the CARD region. Overexpression of the CARD region of MDA5 revealed that the MDA5-mediated signaling pathway could transmit signals by activating the IRF3/NF-κB and IRF3 promoters, promoting the expression of antiviral proteins and cytokine release, thereby inhibiting CIV replication. Upon silencing of MDA5, cytokine production decreased, while the replication ability of CIV was increased. Thus, this study revealed a novel mechanism by which MDA5 mediated CIV infection and provided new avenues for the development of antiviral strategies.

Short communication: isolation and phylogenetic analysis of an avian-origin H3N2 canine influenza virus in dog shelter, China

Virus Genes ◽  
2013 ◽  
Vol 46 (3) ◽  
pp. 554-557 ◽  
Author(s):  
Shuo Su ◽  
Ziguo Yuan ◽  
Jidang Chen ◽  
Jiexiong Xie ◽  
Huatao Li ◽  
...  
Keyword(s):  
Phylogenetic Analysis ◽  
Influenza Virus ◽  
Short Communication ◽  
Canine Influenza Virus ◽  
Avian Origin ◽  
Canine Influenza

PB2 E627K or D701N substitution does not change the virulence of canine influenza virus H3N2 in mice and dogs

2018 ◽  
Vol 220 ◽  
pp. 67-72 ◽  
Author(s):  
Pei Zhou ◽  
Zhenpeng Cao ◽  
Weijie Zeng ◽  
Xiangqi Hao ◽  
Qingxu Zheng ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Canine Influenza Virus ◽  
Canine Influenza

Prevalence of canine influenza virus A (H3N8) in dogs in Germany

2014 ◽  
Vol 202 (1) ◽  
pp. 184-185 ◽  
Author(s):  
Bianka Schulz ◽  
Christina Klinkenberg ◽  
Robert Fux ◽  
Tara Anderson ◽  
Paola de Benedictis ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Influenza Virus A ◽  
Canine Influenza Virus ◽  
Canine Influenza

scholarly journals Serologic Reports of H3N2 Canine Influenza Virus Infection in Dogs in Northeast China

2013 ◽  
Vol 75 (8) ◽  
pp. 1061-1062 ◽  
Author(s):  
Yong-Biao ZHANG ◽  
Ji-Dang CHEN ◽  
Jie-Xiong XIE ◽  
Wan-Jun ZHU ◽  
Chun-Ya WEI ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Northeast China ◽  
Influenza Virus Infection ◽  
Canine Influenza Virus ◽  
Canine Influenza
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