scholarly journals Community‐based, point‐of‐care hepatitis C testing: perspectives and preferences of people who inject drugs

2019 ◽  
Vol 26 (7) ◽  
pp. 919-922 ◽  
Author(s):  
Ned H. Latham ◽  
Alisa Pedrana ◽  
Joseph S. Doyle ◽  
Jessica Howell ◽  
Bridget Williams ◽  
...  
Keyword(s):  
Hepatitis C ◽  
People Who Inject Drugs ◽  
Point Of Care ◽  
Community Based

scholarly journals Decentralized, Community-Based Hepatitis C Point-of-Care Testing and Direct-Acting Antiviral Treatment for People Who Inject Drugs and the General Population in Myanmar: Protocol for a Feasibility Study

10.2196/16863 ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. e16863
Author(s):  
Bridget Louise Draper ◽  
Alisa Pedrana ◽  
Jessica Howell ◽  
Win Lei Yee ◽  
Hla Htay ◽  
...  
Keyword(s):  
Hepatitis C ◽  
General Population ◽  
Feasibility Study ◽  
People Who Inject Drugs ◽  
Point Of Care ◽  
Community Based ◽  
Middle Income ◽  
Hepatitis C Rna ◽  
Direct Acting ◽  
Low And Middle Income

Background The advent of direct-acting antivirals (DAAs) and point-of-care (POC) testing platforms for hepatitis C allow for the decentralization of care to primary care settings. In many countries, access to DAAs is generally limited to tertiary hospitals, with limited published research documenting decentralized models of care in low-and middle-income settings. Objective This study aims to assess the feasibility, acceptability, effectiveness, and cost-effectiveness of decentralized community-based POC testing and DAA therapy for hepatitis C among people who inject drugs and the general population in Yangon, Myanmar. Methods Rapid diagnostic tests for anti-hepatitis C antibodies were carried out on-site and, if reactive, were followed by POC GeneXpert hepatitis C RNA polymerase chain reaction tests. External laboratory blood tests to exclude other major health issues were undertaken. Results were given to participants at their next appointment, with the participants commencing DAA therapy that day if a specialist review was not required. Standard clinical data were collected, and the participants completed behavioral questionnaires. The primary outcome measures are the proportion of participants receiving GeneXpert hepatitis C RNA test, the proportion of participants commencing DAA therapy, the proportion of participants completing DAA therapy, and the proportion of participants achieving sustained virological response 12 weeks after completing DAA therapy. Results Recruitment was completed on September 30, 2019. Monitoring visits and treatment outcome visits are scheduled to continue until June 2020. Conclusions This feasibility study in Myanmar contributes to the evidence gap for community-based hepatitis C care in low- and middle-income settings. Evidence from this study will inform the scale-up of hepatitis C treatment programs in Myanmar and globally.

scholarly journals Decentralized, Community-Based Hepatitis C Point-of-Care Testing and Direct-Acting Antiviral Treatment for People Who Inject Drugs and the General Population in Myanmar: Protocol for a Feasibility Study (Preprint)

2019 ◽  
Author(s):  
Bridget Louise Draper ◽  
Alisa Pedrana ◽  
Jessica Howell ◽  
Win Lei Yee ◽  
Hla Htay ◽  
...  
Keyword(s):  
Hepatitis C ◽  
General Population ◽  
Feasibility Study ◽  
People Who Inject Drugs ◽  
Point Of Care ◽  
Community Based ◽  
Middle Income ◽  
Hepatitis C Rna ◽  
Direct Acting ◽  
Low And Middle Income

BACKGROUND The advent of direct-acting antivirals (DAAs) and point-of-care (POC) testing platforms for hepatitis C allow for the decentralization of care to primary care settings. In many countries, access to DAAs is generally limited to tertiary hospitals, with limited published research documenting decentralized models of care in low-and middle-income settings. OBJECTIVE This study aims to assess the feasibility, acceptability, effectiveness, and cost-effectiveness of decentralized community-based POC testing and DAA therapy for hepatitis C among people who inject drugs and the general population in Yangon, Myanmar. METHODS Rapid diagnostic tests for anti-hepatitis C antibodies were carried out on-site and, if reactive, were followed by POC GeneXpert hepatitis C RNA polymerase chain reaction tests. External laboratory blood tests to exclude other major health issues were undertaken. Results were given to participants at their next appointment, with the participants commencing DAA therapy that day if a specialist review was not required. Standard clinical data were collected, and the participants completed behavioral questionnaires. The primary outcome measures are the proportion of participants receiving GeneXpert hepatitis C RNA test, the proportion of participants commencing DAA therapy, the proportion of participants completing DAA therapy, and the proportion of participants achieving sustained virological response 12 weeks after completing DAA therapy. RESULTS Recruitment was completed on September 30, 2019. Monitoring visits and treatment outcome visits are scheduled to continue until June 2020. CONCLUSIONS This feasibility study in Myanmar contributes to the evidence gap for community-based hepatitis C care in low- and middle-income settings. Evidence from this study will inform the scale-up of hepatitis C treatment programs in Myanmar and globally. INTERNATIONAL REGISTERED REPORT DERR1-10.2196/16863

Engaging people who inject drugs in hepatitis C virus testing and prevention through community-based outreach, in Sydney, Australia

2019 ◽  
Vol 38 (2) ◽  
pp. 177-184 ◽  
Author(s):  
Heidi Coupland ◽  
Bethany White ◽  
Anna Bates ◽  
Ju Nyeong Park ◽  
Jenny Iversen ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
People Who Inject Drugs ◽  
Community Based ◽  
Virus Testing ◽  
Sydney Australia

P0841 : Successful community based treatment of hepatitis C in people who inject drugs

2015 ◽  
Vol 62 ◽  
pp. S653 ◽  
Author(s):  
A.J. Wade ◽  
D. Macdonald ◽  
J.S. Doyle ◽  
A.J. Thompson ◽  
S.K. Roberts ◽  
...  
Keyword(s):  
Hepatitis C ◽  
People Who Inject Drugs ◽  
Community Based

scholarly journals Peer outreach point-of-care testing as a bridge to hepatitis C care for people who inject drugs in Toronto, Canada

2020 ◽  
Vol 80 ◽  
pp. 102755
Author(s):  
Jennifer Broad ◽  
Kate Mason ◽  
Mary Guyton ◽  
Bernadette Lettner ◽  
John Matelski ◽  
...  
Keyword(s):  
Hepatitis C ◽  
People Who Inject Drugs ◽  
Point Of Care ◽  
Point Of Care Testing ◽  
Peer Outreach

Hepatitis C Among High-Risk Alabamians: Disease Burden and Screening Effectiveness

2020 ◽  
Vol 222 (Supplement_5) ◽  
pp. S365-S375
Author(s):  
Anthony B Lee ◽  
Sandra Karumberia ◽  
Ashley Gilmore ◽  
Ebony Williams ◽  
Nichole Bruner ◽  
...  
Keyword(s):  
Hepatitis C ◽  
High Risk ◽  
Disease Burden ◽  
Point Of Care ◽  
Linkage To Care ◽  
Health Centers ◽  
Community Based ◽  
Reflex Testing ◽  
Services Effectiveness ◽  
Screening Effectiveness

Abstract Background The effectiveness of hepatitis C testing and linkage-to-care (LTC) is poorly characterized in low-resource jurisdictions facing gaps in harm reduction, including illegality of syringe exchange services. Effectiveness of a community-based test/LTC program was evaluated in Alabama. Methods In 2016–2018, shelters, drug treatment centers (DTCs), AIDS organizations, and Federally Qualified Health Centers (FQHCs) engaged in screening/LTC. A coordinator navigated individuals to confirm viremia and link to substance use treatment or primary care with hepatitis C prescribers. Results Point-of-care (POC) tested 4293 individuals (10% [427] antibody-positive, 71% [299/419] RNA performed, 80% [241/299] viremia confirmed) and 93% linked to care (225/241). Electronic medical record (EMR)-based reflex strategy screened 4654 (15% [679] antibody positive, 99% [670/679] RNA performed, 64% [433/679] viremia confirmed) and 85% linked to care (368/433). We observed higher odds of RNA confirmation in EMR-based reflex versus POC (OR, 2.07; P < .0001) and higher odds of LTC in EMR-based reflex versus POC (OR, 1.51; P < .0001). Overall, 53% individuals tested were nonbaby boomers. Conclusions In Alabama, screening at high-risk settings identified significant hepatitis C burden and reflex testing outperformed point-of-care linkage indicators. Colocating testing in DTCs and treatment in FQHCs provided key LTC venues to at-risk younger groups.

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