Incidence of hepatitis E virus infection among blood donors in a high endemic area of Central Italy

Author(s):  
Cinzia Marcantonio ◽  
Patrizio Pezzotti ◽  
Roberto Bruni ◽  
Gloria Taliani ◽  
Paola Chionne ◽  
...  
Viruses ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 492
Author(s):  
Magdalena Baymakova ◽  
Krasimira Terzieva ◽  
Rumen Popov ◽  
Elisaveta Grancharova ◽  
Todor Kundurzhiev ◽  
...  

Hepatitis E virus (HEV) infection is widespread among domestic pigs, industrial swine, and wild boars in Bulgaria. The aim of the current research was to present the HEV seroprevalence among blood donors in Bulgaria. In the present study, 555 blood donors (479 males and 76 females) were enrolled from five districts in the country (Shumen, Pleven, Stara Zagora, Plovdiv, and Sofia districts). All blood samples were tested for anti-HEV IgG using the recomWell HEV IgG ELISA test (Mikrogen GmbH, Neuried, Germany). Each participating donor completed a short, structured, and specific questionnaire to document data on the current study. Anti-HEV IgG positive results were detected in 144 (25.9%) blood donors, including 129 (26.9%) males and 15 (19.7%) females. The established HEV seropositivity was 28.8% (23/80) in Shumen district, 23.2% (22/95) in Pleven district, 27.1% (38/140) in Stara Zagora district, 27.5% (44/160) in Plovdiv district, and 21.3% (17/80) in Sofia district. A high HEV seroprevalence was found for persons who declared that they were general hunters (48.7%; 19/39; p = 0.001) and hunters of wild boars (51.6%; 16/31; p = 0.001). We present the first seroprevalence rates of HEV infection in blood donors from Bulgaria. The results of our research showed high HEV seropositivity among blood donors.


Transfusion ◽  
2018 ◽  
Vol 59 (3) ◽  
pp. 1035-1043 ◽  
Author(s):  
Duangnapa Intharasongkroh ◽  
Thanunrat Thongmee ◽  
Pattaratida Sa-nguanmoo ◽  
Sirapa Klinfueng ◽  
Ausanee Duang-in ◽  
...  

Transfusion ◽  
2013 ◽  
Vol 54 (1) ◽  
pp. 49-56 ◽  
Author(s):  
David Juhl ◽  
Sally A. Baylis ◽  
Johannes Blümel ◽  
Siegfried Görg ◽  
Holger Hennig

Transfusion ◽  
2016 ◽  
Vol 57 (2) ◽  
pp. 248-257 ◽  
Author(s):  
Longmu Zhang ◽  
Shuxian Jiao ◽  
Zhongsi Yang ◽  
Lei Xu ◽  
Li Liu ◽  
...  

2016 ◽  
Vol 21 (30) ◽  
Author(s):  
Claudia Lucarelli ◽  
Enea Spada ◽  
Gloria Taliani ◽  
Paola Chionne ◽  
Elisabetta Madonna ◽  
...  

Prevalence of anti-hepatitis E virus (HEV) antibodies is highly variable in developed countries, which seems partly due to differences in assay sensitivity. Using validated sensitive assays, we tested 313 blood donors attending a hospital transfusion unit in central Italy in January and February 2014 for anti-HEV IgG and IgM and HEV RNA. Data on HEV exposure were collected from all donors. Overall anti-HEV IgG prevalence was 49% (153/313). Eating raw dried pig-liver sausage was the only independent predictor of HEV infection (adjusted prevalence rate ratio = 2.14; 95% confidence interval: 1.23–3.74). Three donors were positive for either anti-HEV IgM (n = 2; 0.6%) or HEV RNA (n = 2; 0.6%); they were completely asymptomatic, without alanine aminotransferase (ALT) abnormalities. Of the two HEV RNA-positive donors (both harbouring genotype 3), one was anti-HEV IgG- and IgM-positive, the other was anti-HEV IgG- and IgM-negative. The third donor was positive for anti-HEV IgG and IgM but HEV RNA-negative. HEV infection is therefore hyperendemic among blood donors (80% men 18–64 years-old) from central Italy and associated with local dietary habits. Nearly 1% of donors have acute or recent infection, implying potential transmission to blood recipients. Neither ALT nor anti-HEV IgM testing seems useful to prevent transfusion-transmitted HEV infection.


2012 ◽  
Vol 50 (8) ◽  
pp. 2708-2713 ◽  
Author(s):  
T. Vollmer ◽  
J. Diekmann ◽  
R. Johne ◽  
M. Eberhardt ◽  
C. Knabbe ◽  
...  

2016 ◽  
Vol 64 (2) ◽  
pp. S460
Author(s):  
J. Abreu-Silva ◽  
S.S. Pereira ◽  
J. Teixeira ◽  
R.M.S. Oliveira ◽  
J. Tomaz ◽  
...  

2009 ◽  
Vol 4 (n2) ◽  
pp. 299-301 ◽  
Author(s):  
H. Ikeda ◽  
K. Matsubayashi ◽  
H. Sakata ◽  
H. Takeda ◽  
S. Sato ◽  
...  

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