Effect of viral suppression on hepatic venous pressure gradient in hepatitis C with cirrhosis and portal hypertension

2017 ◽  
Vol 24 (10) ◽  
pp. 823-831 ◽  
Author(s):  
N. Afdhal ◽  
G. T. Everson ◽  
J. L. Calleja ◽  
G. W. McCaughan ◽  
J. Bosch ◽  
...  
Keyword(s):  
Portal Hypertension ◽  
Hepatitis C ◽  
Pressure Gradient ◽  
Viral Suppression ◽  
Venous Pressure ◽  
Hepatic Venous Pressure Gradient

Mo1240 Spleen and Liver Volumes Are Strongly Correlated With Elevated Hepatic Venous Pressure Gradient in Patients With Non-Cirrhotic Portal Hypertension

2015 ◽  
Vol 148 (4) ◽  
pp. S-646-S-647
Author(s):  
Ohad Etzion ◽  
Akeem Adebogun ◽  
Jason Eccleston ◽  
Ahmed M. Gharib ◽  
David E. Kleiner ◽  
...  
Keyword(s):  
Portal Hypertension ◽  
Pressure Gradient ◽  
Venous Pressure ◽  
Hepatic Venous Pressure Gradient ◽  
Strongly Correlated

scholarly journals Impact of propofol sedation on the diagnostic accuracy of hepatic venous pressure gradient measurements in patients with cirrhosis

2021 ◽  
Author(s):  
Fahim Ebrahimi ◽  
David Semela ◽  
Markus Heim
Keyword(s):  
Portal Hypertension ◽  
Pressure Gradient ◽  
Hepatic Vein ◽  
Venous Pressure ◽  
Portal Pressure ◽  
Intraclass Correlation ◽  
Hepatic Venous Pressure Gradient ◽  
Propofol Sedation ◽  
Gradient Measurements ◽  
Awake Condition

Abstract Background Measurement of the hepatic venous pressure gradient (HVPG) is the gold standard to evaluate the presence and severity of portal hypertension. The procedure is generally safe and well tolerated, but nevertheless, some patients demand for sedation. However, it is unknown whether propofol sedation would impair the accuracy of portal pressure measurements. Methods This is a prospective observational cohort study including cirrhotic patients with suspected portal hypertension undergoing invasive measurement of HVPG. Measurements of HVPG were performed in awake condition as well as under sedation with propofol infusion. Results In total, 37 patients were included. Mean HVPG in awake condition was 15.9 mmHg (IQR 13–19) and during sedation 14.1 mmHg (IQR 12–17). While measures of free hepatic vein pressure (FHVP) were not altered after propofol sedation (p = 0.34), wedged hepatic vein pressure values (WHVP) decreased in an average by  2.05 mmHg (95% CI − 2.46 to − 1.16; p < 0.001) which was proportional to the magnitude of HVPG. In 31 out of 37 patients (83.8%), portal hypertension with HVPG ≥ 12 mmHg was found. Under sedation with propofol, two patients (5.4%) with borderline values would have been incorrectly classified as < 12 mmHg. After adjustment for the average difference of − 10%, all patients were correctly classified. Intraclass correlation coefficient between HVPG measurement in awake condition and under propofol sedation was 0.927 (95% CI 0.594–0.975). Conclusions Propofol sedation during HVPG measurements is generally safe, however it may lead to relevant alterations of HVPG readings.

scholarly journals Acute and 14-Day Hepatic Venous Pressure Gradient Response to Carvedilol and Nebivolol in Patients With Liver Cirrhosis

Medicina ◽  
2013 ◽  
Vol 49 (11) ◽  
pp. 73 ◽  
Author(s):  
Vilma Silkauskaite ◽  
Jouzas Kupčinskas ◽  
Andrius Pranculis ◽  
Laimas Jonaitis ◽  
Vitalija Petrenkiene ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Portal Hypertension ◽  
Pressure Gradient ◽  
Venous Pressure ◽  
Hepatic Venous Pressure Gradient ◽  
Alternative Drug

Background and Objective: Alternative drug therapies are needed for the treatment of portal hypertension.[...]

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