Aberrant DNA methylation of G-protein-coupled bile acid receptor Gpbar1 predicts prognosis of acute-on-chronic hepatitis B liver failure

2014 ◽  
Vol 22 (2) ◽  
pp. 112-119 ◽  
Author(s):  
S. Gao ◽  
X.-F. Ji ◽  
F. Li ◽  
F.-K. Sun ◽  
J. Zhao ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Chronic Hepatitis ◽  
Bile Acid ◽  
Hepatitis B ◽  
Liver Failure ◽  
G Protein ◽  
Chronic Hepatitis B ◽  
Bile Acid Receptor ◽  
Aberrant Dna Methylation ◽  
G Protein Coupled

Severe dendritic cell perturbation is actively involved in the pathogenesis of acute-on-chronic hepatitis B liver failure

2008 ◽  
Vol 49 (3) ◽  
pp. 396-406 ◽  
Author(s):  
Zheng Zhang ◽  
Zheng-Sheng Zou ◽  
Jun-Liang Fu ◽  
Lun Cai ◽  
Lei Jin ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Dendritic Cell ◽  
Hepatitis B ◽  
Liver Failure ◽  
Chronic Hepatitis B

scholarly journals The G protein coupled bile acid receptor TGR5 (Gpbar1) modulates endothelin-1 signaling in liver

2020 ◽  
Author(s):  
C Klindt ◽  
M Reich ◽  
B Hellweg ◽  
J Stindt ◽  
J Rahnenführer ◽  
...  
Keyword(s):  
Bile Acid ◽  
G Protein ◽  
Acid Receptor ◽  
Endothelin 1 ◽  
Bile Acid Receptor ◽  
G Protein Coupled

Acute-on-chronic liver failure in chronic hepatitis B: an update

2018 ◽  
Vol 12 (4) ◽  
pp. 341-350 ◽  
Author(s):  
Rui-Hong Zhao ◽  
Yu Shi ◽  
Hong Zhao ◽  
Wei Wu ◽  
Ji-Fang Sheng
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Liver Failure ◽  
Chronic Hepatitis B ◽  
Chronic Liver ◽  
Chronic Liver Failure

scholarly journals Development and validation of the nomogram based on INR and eGFR for estimation of mortality in patients with acute-on-chronic hepatitis B liver failure

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Shengnan Li ◽  
Xiehua Zhang ◽  
Qian Li ◽  
Binyue Lv ◽  
Yefan Zhang ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Liver Disease ◽  
Hepatitis B ◽  
Liver Failure ◽  
Chronic Hepatitis B ◽  
Calibration Curve ◽  
Validation Cohort ◽  
External Validation ◽  
Short Term ◽  
Short Term Mortality

Abstract Aims and objectives Acute-on-chronic hepatitis B liver failure (ACHBLF) is a critical clinical syndrome with a high short-term mortality evolved from chronic hepatitis B (CHB)-related liver disease. Prediction of mortality risk and early intervention can improve the prognosis of patients. This study aimed to develop and validate the nomogram for short-time mortality estimation in ACHBLF patients defined according to Asian Pacific Association for the Study of the Liver (APASL). Methods A study of 105 ACHBLF patients with 90-day follow up was performed to develop the nomogram. Patients were randomly assigned to derivation cohort (n = 75) and validation cohort (n = 35) according to 7:3. Concordance index (C-index), calibration curve and decision curve analysis (DCA) were used to evaluate the nomogram. We also compared the nomogram with APASL ACLF research consortium (AARC) score, model for end-stage liver disease (MELD) score, MELD with serum sodium (MELD-Na) score and albumin-bilirubin (ALBI) score. The nomogram was validated using an external cohort including 40 patients. Results The 28-day and 90-day mortality of 105 patients were respectively 49.52% and 55.24%. Albumin (ALB), international normalized ratio (INR) and estimated glomerular filtration rate (eGFR) were independent predictors for 28-day mortality; INR and eGFR were independent predictors for 90-day mortality. C-index of Nomogram-1 for 28-day mortality and Nomogram-2 for 90-day mortality were respectively 0.82 and 0.81. Calibration curve and Hosmer–Lemeshow test (Nomogram-1, 0.323; Nomogram-2, 0.231) showed optimal agreement between observed and predicted death. Areas under receiver operator characteristic curve(AUROC) of Nomogram-1(0.772) and Nomogram-2(0.771) were larger compared with AARC, MELD, MELD-Na and ALBI score. The results were well estimated in the external validation cohort. Conclusions This study highlighted the predictive value of eGFR, and the nomogram based on INR and eGFR could effectively estimate individualized risk for short-term mortality of ACHBLF patients defined according to APASL.

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