scholarly journals P34: Characterization of the CD8+ T-cell immune response to the hepatitis B virus in the chronic and immunologically controlled infection

2013 ◽  
Vol 20 ◽  
pp. 34-34
Author(s):  
H Kefalakes ◽  
C Jochum ◽  
G Hilgard ◽  
A Kahraman ◽  
A Bohrer ◽  
...  
Keyword(s):  
Immune Response ◽  
Hepatitis B Virus ◽  
T Cell ◽  
Hepatitis B ◽  
Cd8 T Cell ◽  
Cell Immune Response ◽  
B Virus

How Far we are towards Eradication of HBV Infection

2015 ◽  
Vol 24 (4) ◽  
pp. 473-479 ◽  
Author(s):  
Mihai Voiculescu
Keyword(s):  
Immune Response ◽  
Hepatitis B Virus ◽  
T Cell ◽  
Hepatitis B ◽  
T Cell Receptors ◽  
Hepatitis B Surface Antigen ◽  
Hbv Infection ◽  
Major Health Problem ◽  
Cell Receptors ◽  
B Virus

Hepatitis B virus (HBV) infection is a major health problem with an important biological and a significant socio-economic impact all over the world. There is a high pressure to come up with a new and more efficient strategy against HBV infection, especially after the recent success of HCV treatment. Preventing HBV infection through vaccine is currently the most efficient way to decrease HBV-related cirrhosis and liver cancer incidence, as well as the best way to suppress the HBV reservoir. The vaccine is safe and efficient in 80-95% of cases. One of its most important roles is to reduce materno-fetal transmission, by giving the first dose of vaccine in the first 24 hours after birth. Transmission of HBV infection early in life is still frequent, especially in countries with high endemicity.Successful HBV clearance by the host is immune-mediated, with a complex combined innate and adaptive cellular and humoral immune response. Different factors, such as the quantity and the sequence of HBV epitope during processing by dendritic cells and presenting by different HLA molecules or the polymorphism of T cell receptors (TOL) are part of a complex network which influences the final response. A new potential therapeutic strategy is to restore T-cell antiviral function and to improve innate and adaptive immune response by immunotherapeutic manipulation.It appears that HBV eradication is far from being completed in the next decades, and a new strategy against HBV infection must be considered. Abbreviations: ALT: alanine aminotransferase; APC: antigen presenting cells; cccDNA: covalently closed circular DNA; HBIG: hepatitis B immunoglobulin; HbsAg: hepatitis B surface antigen; HBV: hepatitis B virus; HCC: hepatocellular carcinoma; CTL: cytotoxic T lymphocyte; IFN: interferon; NUC: nucleos(t)ide analogues; pg RNA: pre genomic RNA; TLR: toll-like receptors; TOL: T cell receptors.

Immunomodulation and RNA interference alter Hepatitis B Virus‐specific CD8 T cell recognition of infected HepG2‐NTCP

Hepatology ◽  
2021 ◽  
Author(s):  
Adrian Kuipery ◽  
Juan Diego Sanchez Vasquez ◽  
Aman Mehrotra ◽  
Jordan J. Feld ◽  
Harry L. A. Janssen ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Rna Interference ◽  
T Cell ◽  
Hepatitis B ◽  
Cd8 T Cell ◽  
Cell Recognition ◽  
T Cell Recognition ◽  
B Virus

scholarly journals NK cells contribute to hepatic CD8+ T cell failure in hepatitis B virus-carrier mice after alcohol consumption

2020 ◽  
Vol 286 ◽  
pp. 198085
Author(s):  
Shuling Jiang ◽  
Yun Zhu ◽  
Chen Cheng ◽  
Yue Li ◽  
Tai Ma ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
T Cell ◽  
Alcohol Consumption ◽  
Hepatitis B ◽  
Nk Cells ◽  
Cd8 T Cell ◽  
B Virus ◽  
Hepatitis B Virus Carrier ◽  
Virus Carrier

Characterization of the immune response to the hepatitis B virus X protein in acute and chronic HBV infection

1989 ◽  
Vol 9 ◽  
pp. S182
Author(s):  
M. Levrero ◽  
A. Franco ◽  
E. De Marzio ◽  
C. Balsano ◽  
M.L. Avantaggiati ◽  
...  
Keyword(s):  
Immune Response ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Hbv Infection ◽  
X Protein ◽  
Chronic Hbv Infection ◽  
B Virus ◽  
Chronic Hbv

scholarly journals CD8+T Cell Control of Hepatitis B Virus Replication: Direct Comparison between Cytolytic and Noncytolytic Functions

2009 ◽  
Vol 184 (1) ◽  
pp. 287-295 ◽  
Author(s):  
Sandra Phillips ◽  
Shilpa Chokshi ◽  
Antonio Riva ◽  
Alexander Evans ◽  
Roger Williams ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
T Cell ◽  
Hepatitis B ◽  
Virus Replication ◽  
Cd8 T Cell ◽  
Cell Control ◽  
B Virus
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