scholarly journals Plasmodium knowlesi: Clinical Presentation and Laboratory Diagnosis of the First Human Case in a Scottish Traveler

2014 ◽  
Vol 21 (5) ◽  
pp. 357-360 ◽  
Author(s):  
Claire J. Cordina ◽  
Richard Culleton ◽  
Brian L. Jones ◽  
Catherine C. Smith ◽  
Alisdair A. MacConnachie ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Plasmodium Knowlesi ◽  
Laboratory Diagnosis ◽  
Human Case

scholarly journals A 3-YEAR FOLLOW-UP OF A BRAZILIAN AIDS PATIENT WITH PROTRACTED DIARRHEA CAUSED BY Enterocytozoon bieneusi

1998 ◽  
Vol 40 (4) ◽  
pp. 215-218 ◽  
Author(s):  
Patrícia BRASIL ◽  
Daurita D. DE PAIVA ◽  
Dirce B. DE LIMA ◽  
Edson Jurado DA SILVA ◽  
José Mauro PERALTA ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Chronic Diarrhea ◽  
Antiviral Treatment ◽  
Laboratory Diagnosis ◽  
Enterocytozoon Bieneusi ◽  
Hiv Positive ◽  
Opportunistic Pathogens ◽  
Microsporidian Parasite ◽  
The World

Enterocytozoon bieneusi is the most prevalent microsporidian parasite that causes gastrointestinal infection in persons with AIDS. Microsporidia are increasingly recognized as important opportunistic pathogens all over the world but in Brazil only few cases have been reported due either to the non awareness of the clinical presentation of the disease or to difficulties in the laboratory diagnosis. We report a 3-year follow-up of a Brazilian HIV-positive patient in whom microsporidial spores were detected in stools and were identified as E. bieneusi using electron microscopy and PCR. The patient presented with chronic diarrhea, CD4 T-lymphocytes count below 100/mm3 and microsporidial spores were consistently detected in stools. Albendazole was given to the patient in several occasions with transient relief of the diarrhea, which reappeared as soon as the drug was discontinued. Nevertheless, a diarrhea-free period with weight gain up to 18 Kg occurred when a combination of nucleoside and protease inhibitors was initiated as part of the antiviral treatment.

scholarly journals Canine sporotrichosis in Rio de Janeiro, Brazil: clinical presentation, laboratory diagnosis and therapeutic response in 44 cases (1998–2003)

2006 ◽  
Vol 44 (1) ◽  
pp. 87-92 ◽  
Author(s):  
Tânia M. P. Schubach ◽  
Armando Schubach ◽  
Thais Okamoto ◽  
Mônica B. L. Barros ◽  
Fabiano Borges Figueiredo ◽  
...  
Keyword(s):  
Rio De Janeiro ◽  
Therapeutic Response ◽  
Clinical Presentation ◽  
Laboratory Diagnosis

scholarly journals Multicenter Evaluation of the C6 Lyme ELISA Kit for the Diagnosis of Lyme Disease

2020 ◽  
Vol 8 (3) ◽  
pp. 457
Author(s):  
Silvia Zannoli ◽  
Michela Fantini ◽  
Simona Semprini ◽  
Barbara Marchini ◽  
Barbara Ceccarelli ◽  
...  
Keyword(s):  
Lyme Disease ◽  
Laboratory Tests ◽  
Patient Management ◽  
Clinical Presentation ◽  
Laboratory Diagnosis ◽  
Antibody Detection ◽  
Elisa Kit ◽  
Lower Specificity ◽  
Good Concordance ◽  
Step Algorithm

Lyme disease (LD), caused by infection with Borrelia burgdorferi, is the most common tick-borne infection in many regions of Eurasia. Antibody detection is the most frequently used laboratory test, favoring a two-step serodiagnostic algorithm; immunoenzymatic detection of antibodies to C6 has been shown to perform similarly to a standard two-step workflow. The aim of this study was the performance evaluation of the C6 Lyme ELISA kit compared to a standard two-step algorithm in three laboratories located in the northeastern region of Italy which cater to areas with different LD epidemiology. A total of 804 samples were tested, of which 695 gave concordant results between C6 testing and routine workflow (564 negative, 131 positive). Wherever available, clinical presentation and additional laboratory tests were analyzed to solve discrepancies. The C6 based method showed a good concordance with the standard two-step algorithm (Cohen’s κ = 0.619), however, the distribution of discrepancies seems to point towards a slightly lower specificity of C6 testing, which is supported by literature and could impact on patient management. The C6 ELISA, therefore, is not an ideal stand-alone test; however, if integrated into a two-step algorithm, it might play a part in achieving a sensitive, specific laboratory diagnosis of LD.

RECENT ADVANCES IN LABORATORY DIAGNOSIS OF SYSTEMIC AUTOIMMUNE DISEASES.

2021 ◽  
pp. 22-28
Author(s):  
Indira Ananthapadmanab asamy ◽  
G. Rajaram ◽  
C.H.Srinivasa Rao
Keyword(s):  
Differential Diagnosis ◽  
Autoimmune Diseases ◽  
Clinical Presentation ◽  
Laboratory Diagnosis ◽  
The Body ◽  
Systemic Autoimmune Diseases ◽  
Western Countries ◽  
Recent Advances ◽  
Self Antigen

Introduction: Autoimmunity is a condition in which the body's own cells which are immunocompetent and the antibodies, acts against its own self-antigen which will result in structural and functional damage to the body. The diseases caused by this phenomenon are called Autoimmune diseases. Autoimmune diseases are more commonly seen in females. Hundred thousands of individuals in the Western countries are affected. The diagnosis is made from the clinical presentation of the patient with which a differential diagnosis is made, following which various tests both phenotyping methods and genotyping methods are carried out to conclude the nal diagnosis. Conclusion: The genotyping methods play the most important role in the laboratory diagnosis of systemic immune diseases.

Human granulocytic anaplasmosis in eastern France: clinical presentation and laboratory diagnosis

2012 ◽  
Vol 72 (3) ◽  
pp. 214-218 ◽  
Author(s):  
Christelle Koebel ◽  
Aurélie Kern ◽  
Sophie Edouard ◽  
Anh Thu Hoang ◽  
Noéline Celestin ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Laboratory Diagnosis ◽  
Human Granulocytic Anaplasmosis ◽  
Granulocytic Anaplasmosis

scholarly journals She Has The Blues: An Unusual Case of Copper Sulphate Intoxication

2020 ◽  
Author(s):  
Aurore Moussiegt ◽  
Luis Ferreira ◽  
Jérome Aboab ◽  
Daniel Silva
Keyword(s):  
Unusual Case ◽  
Clinical Presentation ◽  
Multiorgan Failure ◽  
Symptomatic Treatment ◽  
Laboratory Diagnosis ◽  
Essential Trace Element ◽  
Case Presentation ◽  
Her Family ◽  
Intrarectal Administration ◽  
Copper Intoxication

Background: Copper is an essential trace element of the human body. However, it is related to many diseases. Copper intoxication is not common in Western countries, but needs to be rapidly recognised because of its high lethality. Case presentation: We report the case of a 40-year-old woman who presented to the emergency department after performing intrarectal administration of a blue powder sent from Cameroon by her family, in the belief that this would help her to get pregnant. Her evolution was complicated by multiorgan failure and the unusual circumstances. The diagnosis was suspected on the basis of the clinical presentation and the colour of the powder, and confirmed by blood dosage and toxicological analysis of the powder. She underwent symptomatic treatment, and the outcome was progressively favourable, apart from persistent chronic renal failure with dependence on dialysis. Conclusion: Copper intoxications are rare but severe. Laboratory diagnosis of the condition is not an issue; the difficulty is suspecting it and quickly initiating chelation treatment associated with symptomatic treatments.

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