scholarly journals Peripheral serotonin lacks effects on endothelial adhesion molecule expression in acute inflammation

2021 ◽  
Author(s):  
Maximilian Mauler ◽  
Nancy Schanze ◽  
Krystin Krauel ◽  
Claudia Schoenichen ◽  
Franziska Glatzki ◽  
...  
Keyword(s):  
Adhesion Molecule ◽  
Acute Inflammation ◽  
Adhesion Molecule Expression ◽  
Endothelial Adhesion Molecule

Endothelial adhesion molecule expression in an in vitro model of inflammation

2002 ◽  
Vol 325 (1-2) ◽  
pp. 171-175 ◽  
Author(s):  
Heide Daxecker ◽  
Markus Raab ◽  
Snezana Markovic ◽  
Alireza Karimi ◽  
Andrea Griesmacher ◽  
...  
Keyword(s):  
Adhesion Molecule ◽  
In Vitro Model ◽  
Adhesion Molecule Expression ◽  
Endothelial Adhesion Molecule ◽  
Vitro Model

scholarly journals Role of glucocorticoids in neutrophil and endothelial adhesion molecule expression and function

1992 ◽  
Vol 1 (2) ◽  
pp. 101-106 ◽  
Author(s):  
Kevin D. Forsyth ◽  
Vivienne Talbot
Keyword(s):  
Inflammatory Response ◽  
Adhesion Molecules ◽  
Adhesion Molecule ◽  
Antigen Expression ◽  
Neutrophil Adhesion ◽  
Adhesion Molecule Expression ◽  
Chronic Inflammatory Response ◽  
Endothelial Adhesion Molecule ◽  
And Function

Glucocorticoids are very effective inhibitors of both the acute and chronic inflammatory response. In this study the hypothesis that glucocorticoids inhibit an early component of the inflammatory response, neutrophil adhesion to endothelium, by down-regulation of adhesion molecules on neutrophils or endothelium was examined. No effect of dexamethasone on neutrophil adhesion to endothelium or of antigen expression by neutrophils or endothelium was found. The mechanism of action of glucocorticoids in the inflammatory response is probably not mediated by alterations in adhesion molecules.

scholarly journals Endothelial Adhesion Molecule Expression and Its Inhibition by Recombinant Bactericidal/Permeability-Increasing Protein Are Influenced by the Capsulation and Lipooligosaccharide Structure ofNeisseria meningitidis

1999 ◽  
Vol 67 (11) ◽  
pp. 5626-5633 ◽  
Author(s):  
Garth L. J. Dixon ◽  
Robert S. Heyderman ◽  
Karolena Kotovicz ◽  
Dominic L. Jack ◽  
Svein R. Andersen ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Neisseria Meningitidis ◽  
Adhesion Molecules ◽  
Adhesion Molecule ◽  
Meningococcal Disease ◽  
Clinical Manifestations ◽  
Adhesion Molecule Expression ◽  
Central Process ◽  
Potent Inducer ◽  
Endothelial Adhesion Molecule

ABSTRACT Vascular endothelial injury is responsible for many of the clinical manifestations of severe meningococcal disease. Binding and migration of activated host inflammatory cells is a central process in vascular damage. The expression and function of adhesion molecules regulate interactions between leukocytes and endothelial cells. Little is known about how meningococci directly influence these receptors. In this study we have explored the effect of Neisseria meningitidison endothelial adhesion molecule expression and found this organism to be a potent inducer of the adhesion molecules CD62E, ICAM-1, and VCAM-1. Exposure of endothelium to a serogroup B strain ofNeisseria meningitidis, B1940, and a range of isogenic mutants revealed that lipooligosaccharide (LOS) structure and capsulation influence the expression of adhesion molecules. Following only a brief exposure (15 min) to the bacteria, there were large differences in the capacity of the different mutants to induce vascular cell adhesion molecules, with the unencapsulated and truncated LOS strains being most potent (P < 0.05). Furthermore, the pattern of cell adhesion molecule expression was different with purified endotoxin from that with intact bacteria. Meningococci were more potent stimuli of CD62E expression than was endotoxin, whereas endotoxin was at least as effective as meningococci in inducing ICAM-1 and VCAM-1. The effect of bactericidal/permeability increasing protein (rBPI21), an antibacterial molecule with antiendotoxin properties, was also dependent on LOS structure. The strains which possessed a truncated or nonsialylated LOS, whether capsulated or not, were more sensitive to the inhibitory effects of rBPI21. These findings could have important implications for the use of antiendotoxin therapy in meningococcal disease.

Brain Endothelial Adhesion Molecule Expression in Experimental Colitis

2001 ◽  
Vol 8 (2) ◽  
pp. 105-114 ◽  
Author(s):  
Miquel Sans ◽  
Shigeyuki Kawachi ◽  
Antonio Soriano ◽  
Antonio Palacín ◽  
Zenichi Morise ◽  
...  
Keyword(s):  
Adhesion Molecule ◽  
Experimental Colitis ◽  
Adhesion Molecule Expression ◽  
Endothelial Adhesion Molecule
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