The carboxyl‐terminal region of coagulation serine proteases: A matter of cut and change

2021 ◽  
Vol 19 (4) ◽  
pp. 917-919
Author(s):  
Alessio Branchini
Keyword(s):  
Serine Proteases ◽  
Terminal Region ◽  
Carboxyl Terminal

scholarly journals Removal of the carboxyl-terminal region of phospholipase C-beta 1 by calpain abolishes activation by G alpha q.

1993 ◽  
Vol 268 (5) ◽  
pp. 3710-3714 ◽  
Author(s):  
D. Park ◽  
D.Y. Jhon ◽  
C.W. Lee ◽  
S.H. Ryu ◽  
S.G. Rhee
Keyword(s):  
Phospholipase C ◽  
Terminal Region ◽  
Carboxyl Terminal ◽  
G Alpha Q

scholarly journals Role of the carboxyl-terminal region of arrestin in binding to phosphorylated rhodopsin

1991 ◽  
Vol 266 (23) ◽  
pp. 15334-15339 ◽  
Author(s):  
K. Palczewski ◽  
J. Buczyłko ◽  
N.R. Imami ◽  
J.H. McDowell ◽  
P.A. Hargrave
Keyword(s):  
Terminal Region ◽  
Carboxyl Terminal

Methylenetetrahydrofolate dehydrogenase – methenyltetrahydrofolate cyclohydrolase – formyltetrahydrofolate synthetase from porcine liver Location of the activities in two domains of the multifunctional polypeptide

1979 ◽  
Vol 57 (6) ◽  
pp. 806-812 ◽  
Author(s):  
L. U. L. Tan ◽  
R. E. MacKenzie
Keyword(s):  
Terminal Region ◽  
Synthetase Activity ◽  
Terminal Portion ◽  
Porcine Liver ◽  
Pig Liver ◽  
Formyltetrahydrofolate Synthetase ◽  
Partial Identity ◽  
Amino Terminal ◽  
Methylenetetrahydrofolate Dehydrogenase ◽  
Carboxyl Terminal

Chymotryptic cleavage of the trifunctional protein methylenetetrahydrofolate dehydrogenase – methenyltetrahydrofolate cyclohydrolase – formyltetrahydrofolate synthetase from pig liver yields a fragment of two-thirds the original polypeptide that retains only synthetase activity. A smaller polypeptide corresponding to about one-third of the original polypeptide was shown earlier to retain dehydrogenase–cyclohydrolase activity. On immunodiffusion, the synthetase fragment cross-reacts and shows partial identity with antibodies raised against the uncleaved enzyme but shows nonidentity with the dehydrogenase–cyclohydrolase fragment, suggesting that the two fragments are derived from different regions of the polypeptide. Amino-terminal analysis of the peptides and uncleaved enzyme indicate that the dehydrogenase–cyclohydrolase activities are located at the amino-terminal region and the synthetase near the carboxyl-terminal portion of the polypeptide.

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