scholarly journals Liver transplantation as a novel strategy for resolution of congenital afibrinogenemia in a pediatric patient

2020 ◽  
Vol 18 (12) ◽  
pp. 3232-3235 ◽  
Author(s):  
Fernando F. Corrales‐Medina ◽  
Tamir Miloh ◽  
Candelaria O’Farrell ◽  
David M. Andrews ◽  
Akin Tekin ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Pediatric Patient ◽  
Congenital Afibrinogenemia ◽  
Novel Strategy

scholarly journals Correction of extrahepatic portal hypertension in pediatric patient after liver transplantation

2017 ◽  
Vol 19 (1) ◽  
pp. 47-51
Author(s):  
A. R. Monakhov ◽  
B. L. Mironkov ◽  
T. A. Dzhanbekov ◽  
K. O. Semash ◽  
Kh. M. Khizroev ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Blood Flow ◽  
Portal Hypertension ◽  
Portal Vein ◽  
Pediatric Patient ◽  
Portal Blood Flow ◽  
Portal Blood ◽  
Positive Trend ◽  
Portal Vein Stenosis ◽  
Vein Stenosis

Introduction. Liver transplantation is a multi-component and complex type of operative treatment. Patients undergoing such a treatment sometimes are getting various complications. One of these complications is a portal hypertension associated with portal vein stenosis.Materials and methods. In 6 years after the left lateral section transplantation from living donor in a pediatric patient the signs of portal hypertension were observed. Stenosis of the portal vein was revealed. Due to this fact percutaneous transhepatic correction of portal vein stenosis was performed.Results. As a result of the correction of portal blood flow in the patient a positive trend was noted. According to the laboratory and instrumental methods of examination the graft had a normal function, portal blood flow was adequate. In order to control the stent patency Doppler ultrasound and MSCT of the abdominal cavity with intravenous bolus contrasting were performed. Due to these examinations the stent function was good, the rate of blood flow in the portal vein due to Doppler data has reached 80 cm/sec, and a decrease of the spleen size was noted.Conclusion. Diagnosis and timely detection of portal vein stenosis in patients after liver transplantation are very important for the preservation of graft function and for the prevention of portal hypertension. In order to do that, ultrasound Doppler fluorimetry examination needs to be performed to each patient after liver transplantation. In cases of violation of the blood flow in the portal vein CT angiography performance is needed. Percutaneous transhepatic stenting of portal vein is a minimally invasive and highly effective method of correction of portal hypertension. Antiplatelet therapy and platelet aggregation control are the prerequisites for successful stent function.

Pediatric Liver Transplantation

2018 ◽  
Author(s):  
Jonathon Nelson ◽  
Franklyn P. Cladis
Keyword(s):  
Liver Transplantation ◽  
Liver Transplant ◽  
Pediatric Patient ◽  
Hepatic Failure ◽  
Pediatric Population ◽  
Donor Pool ◽  
Pediatric Pathology ◽  
Intraoperative Management ◽  
Immunosuppressant Medications ◽  
The 1960S

Liver transplantation has become a standard surgical treatment for pediatric patients with hepatic failure, tumors, and metabolic derangements. Liver transplantation in the pediatric population can be extremely challenging for the anesthesiologist due to multiple perioperative considerations. The first successful liver transplant was performed in a pediatric patient in the 1960s, and since then, there have been significant advances in immunosuppressant medications and preservation solutions which have led to improved survival. Nevertheless, the number of liver transplants continues to be limited by organ availability, although the pediatric donor pool has been increased by living related donors and split livers. The most common pediatric pathology that results in hepatic failure and transplantation is biliary atresia. This chapter covers the perioperative care of a pediatric patient undergoing a liver transplant, from the preoperative preparation to the intraoperative management, and discusses postoperative challenges which may be encountered while in the intensive care unit.

scholarly journals Fifty Years of Experience with Propylthiouracil-Associated Hepatotoxicity: What Have We Learned?1

1997 ◽  
Vol 82 (6) ◽  
pp. 1727-1733 ◽  
Author(s):  
Katherine V. Williams ◽  
Sunil Nayak ◽  
Dorothy Becker ◽  
Jorge Reyes ◽  
Lynn A. Burmeister
Keyword(s):  
Liver Transplantation ◽  
Pediatric Patient ◽  
Clinical Evaluation ◽  
Thyroid Disease ◽  
Patient Management ◽  
English Language ◽  
Optimal Management ◽  
Exact Test ◽  
Medline Search

Abstract The aim of this study was to determine the optimal management of patients with propylthiouracil (PTU) hepatotoxicity. A MEDLINE search for English language cases of PTU hepatotoxicity between 1966 and April 1996 was performed, and additional cases were cross-referenced. Twenty-seven cases were selected based on the availability of information on patient management after the onset of hepatotoxicity. Eighty-five percent of the selected cases met this criterion. A detailed summary of the management of two cases of PTU hepatotoxicity at our institutions is also provided. Although most patients recovered once PTU was stopped, seven patients died. Patients with PTU hepatotoxicity who survived were more likely to have received 131I during the course of their illness than those who died (P < 0.03, by Fisher’s exact test). In our two patients, hyperbilirubinemia was linearly associated with progressively decreasing T4 levels (r = 0.91; P < 0.001) despite the presence of clinical thyrotoxicosis in one of the patients. These findings demonstrate the need for appropriate clinical evaluation and treatment of thyroid disease during the course of hepatotoxicity. Additionally, we report the first pediatric patient with PTU hepatotoxicity to undergo liver transplantation. The emerging role of liver transplantation in these patients is discussed.

Living donor liver transplantation in a pediatric patient with preexisting yolk sac tumor

2016 ◽  
Vol 21 (2) ◽  
pp. e12856 ◽  
Author(s):  
Taiichi Wakiya ◽  
Yoshikazu Toyoki ◽  
Keinosuke Ishido ◽  
Daisuke Kudo ◽  
Norihisa Kimura ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Pediatric Patient ◽  
Living Donor ◽  
Living Donor Liver Transplantation ◽  
Yolk Sac ◽  
Yolk Sac Tumor ◽  
Donor Liver ◽  
Donor Liver Transplantation

ORTHOTOPIC LIVER TRANSPLANTATION FOR METABOLIC LIVER DISEASE IN THE PEDIATRIC PATIENT

1998 ◽  
Vol 66 (8) ◽  
pp. S44
Author(s):  
J A Goss ◽  
C R Shackleton ◽  
S V McDiarmid ◽  
B L Reemtsen ◽  
T S Dulkanchainun ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Disease ◽  
Pediatric Patient ◽  
Orthotopic Liver Transplantation ◽  
Metabolic Liver Disease

A PEDIATRIC PATIENT WITH CLASSICAL CITRULLINEMIA WHO UNDERWENT LIVING-RELATED PARTIAL LIVER TRANSPLANTATION

2001 ◽  
Vol 71 (10) ◽  
pp. 1495-1497 ◽  
Author(s):  
Kyoko Ban ◽  
Naruji Sugiyama ◽  
Kohachiro Sugiyama ◽  
Yoshiro Wada ◽  
Tatsuya Suzuki ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Pediatric Patient ◽  
Partial Liver Transplantation ◽  
Living Related
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