Non‐invasive recanalization of deep venous thrombosis by high frequency ultrasound in a swine model with follow‐up

2020 ◽  
Vol 18 (11) ◽  
pp. 2889-2898
Author(s):  
Guillaume Goudot ◽  
Lina Khider ◽  
Costantino Del Giudice ◽  
Tristan Mirault ◽  
Alexandre Galloula ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
High Frequency ◽  
Swine Model ◽  
High Frequency Ultrasound ◽  
Non Invasive ◽  
Frequency Ultrasound

High‐frequency ultrasound as a non‐invasive tool in predicting early hidradenitis suppurativa fistulization in comparison with the Hurley system

2020 ◽  
Author(s):  
Izelda Maria Carvalho Costa ◽  
Camille Bresolin Pompeu ◽  
Eduardo Botelho Silva Mauad ◽  
Mariana Carvalho Costa ◽  
Vanessa Guimarães de Freitas Lima ◽  
...  
Keyword(s):  
High Frequency ◽  
Hidradenitis Suppurativa ◽  
High Frequency Ultrasound ◽  
Non Invasive ◽  
Frequency Ultrasound

scholarly journals Photoacoustic/Ultrasound/Optical Coherence Tomography Evaluation of Melanoma Lesion and Healthy Skin in a Swine Model

Sensors ◽  
2019 ◽  
Vol 19 (12) ◽  
pp. 2815 ◽  
Author(s):  
Karl Kratkiewicz ◽  
Rayyan Manwar ◽  
Ali Rajabi-Estarabadi ◽  
Joseph Fakhoury ◽  
Jurgita Meiliute ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
High Frequency ◽  
Photoacoustic Imaging ◽  
Diagnostic Methods ◽  
Swine Model ◽  
Optical Coherence ◽  
Healthy Skin ◽  
High Frequency Ultrasound ◽  
Rapid Drop ◽  
Frequency Ultrasound

The marked increase in the incidence of melanoma coupled with the rapid drop in the survival rate after metastasis has promoted the investigation into improved diagnostic methods for melanoma. High-frequency ultrasound (US), optical coherence tomography (OCT), and photoacoustic imaging (PAI) are three potential modalities that can assist a dermatologist by providing extra information beyond dermoscopic features. In this study, we imaged a swine model with spontaneous melanoma using these modalities and compared the images with images of nearby healthy skin. Histology images were used for validation.

scholarly journals High frequency ultrasound of skin involvement in systemic sclerosis – a follow-up study

2015 ◽  
Vol 17 (1) ◽  
Author(s):  
Roger Hesselstrand ◽  
Johanna Carlestam ◽  
Marie Wildt ◽  
Gunnel Sandqvist ◽  
Kristofer Andréasson
Keyword(s):  
Systemic Sclerosis ◽  
High Frequency ◽  
Skin Involvement ◽  
High Frequency Ultrasound ◽  
Follow Up Study ◽  
Frequency Ultrasound

P2765Efficacy of venous recanalization by noninvasive pulsed cavitational ultrasound therapy on swine model of acute deep venous thrombosis

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
L Khider ◽  
G Goudot ◽  
C Del Giudice ◽  
T Mirault ◽  
P Bruneval ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Surrounding Tissue ◽  
Ultrasound Therapy ◽  
Swine Model ◽  
High Morbidity ◽  
Linear Probe ◽  
Venous Recanalization

Abstract Background Post thrombotic syndrome is a frequent complication of deep venous thrombosis and is associated with high morbidity and hospitalization. Treatments currently available are invasive, involve use of endovenous procedures with stents and balloons, and frequently require general anesthesia. Pulsed cavitational ultrasound therapy (PCUT) emerged recently as a new technique to destroy remotely soft tissue. We recently demonstrated that PCUT was able to recanalize non-invasively in in vitro model of acute venous thrombosis (human blood clot). Purpose We aim to test the safety and efficacy of venous recanalization by noninvasive PCUT in vivo swine model of acute venous thrombosis. Methods All the experiments were performed on White large X Landrace swine. We induced an acute femoral deep venous thrombosis by using occlusive balloons introduced from jugular and popliteal vein combined with local injection of 50 IU of human thrombin. A 3 cm length occlusive thrombosis was obtained after 2 hours. Swines were divided in three groups: one with PCUT without follow-up (n=11), one with PCUT and follow-up at 14 days (n=8), and a control group also followed for 14 days (n=5). Acutely and during the follow up all swines received curative anticoagulation. To achieve PCUT, a 2.25 MHz transducer centered by a linear probe was used and cavitation was obtained in the center of the vein (Figure). After manual determination of thrombus location, a robotic arm was used to automatically move the transducer along the thrombus. Effectiveness of recanalization was evaluated by echo-Doppler and phlebography. Safety was assessed by Doppler ultrasound of the insonified area (artery, veins and surrounding tissue) and by histological analysis (local femoral vein and artery and lungs for pulmonary embolism). Results Among the 24 swines, we obtained 22 occlusive venous thromboses and 2 partial. The median length of the thrombus was 26±4.4 mm with vein diameter of 8.5±1.6 mm. Acutely, thrombosis recanalization was systematically obtained among the 19 swine with PCUT with median treatment duration of 33 minutes with residual diameter of 2.9±0.9 mm. No extravasation of contrast material or hematoma was observed after the therapy. After a 14-day follow-up, 75% of recanalisation remain permeable vs. 0% of vein permeable in the no therapy group (p=0.008). Residual diameter was 2.6±1.2 mm, which correspond to 50% of the venous diameter. No vein or artery damage and no embolism or pulmonary infarction was observed in all pigs. Figure 1 Conclusion We have demonstrated in vivo the safety and the efficacy of PCUT for non-invasive venous recanalization, persistent after 2 weeks. Acknowledgement/Funding French society of cardiology

scholarly journals P164 Can non-invasive techniques be used to image calcinosis?

Rheumatology ◽  
2020 ◽  
Vol 59 (Supplement_2) ◽  
Author(s):  
Tonia L Moore ◽  
Elizabeth Marjanovic ◽  
Joanne B Manning ◽  
Graham Dinsdale ◽  
Sarah Wilkinson ◽  
...  
Keyword(s):  
High Frequency ◽  
Significant Proportion ◽  
Laser Speckle ◽  
Adjacent Area ◽  
High Frequency Ultrasound ◽  
Laser Speckle Imaging ◽  
Speckle Imaging ◽  
Non Invasive ◽  
Invasive Techniques ◽  
Frequency Ultrasound

Abstract Background A significant proportion of patients with systemic sclerosis (SSc, 20-40%) will develop subcutaneous calcinotic deposits which are painful and can perforate the skin, causing ulceration. The underlying aetiology is unknown and there is currently no effective treatment. Diagnosis is often made with plain radiography, which is not ideal for long-term monitoring. Identifying non-invasive techniques which do not involve ionising radiation will improve our understanding of calcinosis and how to monitor this over time, facilitating the development of potential treatments. The aim of this study was to assess several non-invasive imaging techniques to measure oxygenation (multispectral imaging), perfusion (thermography [a pseudo measure of perfusion] and laser speckle imaging) and size and depth (high frequency ultrasound) of the calcinoses. The hypothesis of the study was that there would be relationships between oxygenation, perfusion and calcinosis size and depth. Methods Twenty-one patients with SSc (all female, median age 63 (IQR 55 to 70) years; disease duration since onset of first non-Raynaud’s feature 14 (9 to 23) years, Raynaud’s phenomenon duration 23 (12- 36) years; underwent imaging of calcinosis. Measurements of oxygenation, perfusion and vessel size and depth were performed at the site of calcinosis and adjacent skin. Results There was no difference in oxygenation at the site of calcinosis vs adjacent median 0.15 (IQR 0.07 to 0.22) vs. 0.16 (0.00 to 0.21) arbitrary units respectively; non-significant. There was a trend for skin temperature (perfusion) to be lower at the site of the calcinosis compared to the adjacent area (calcinosis, 31.4 (28.4 to 35.6) vs adjacent 32.8 (28.4 to 35.7) oC; p = 0.052. Perfusion as measured by speckle imaging was significantly reduced 107.3 [60.3 to 213.4] vs 312.1 [107.8 to 432.2] arbitrary perfusion units; p < 0.01. The mean depth of the calcinoses was 1.5 (1.11 to 2.07) cm and mean lesion area was 3.06 (2.33 to 4.62) cm2. No relationships were identified between perfusion, oxygenation or calcinosis depth and area. Conclusion Perfusion is reduced at the calcinotic sites, as measured by laser speckle imaging and also (although not significantly) as measured indirectly by thermography. That perfusion was decreased in the area of the calcinosis versus the adjacent skin may be due to the pressure on the skin leading to ischaemia, or it may be that calcinosis develops in areas which are under-perfused. This study has demonstrated the feasibility of imaging calcinosis properties. The ability to measure the depth and subcutaneous area with high frequency ultrasound may provide a useful outcome measure of treatment efficacy. Disclosures T.L. Moore None. E. Marjanovic None. J.B. Manning None. G. Dinsdale None. S. Wilkinson None. M.R. Dickinson None. A.L. Herrick None. A.K. Murray None.

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