Thrombin generation predicts early recurrence in breast cancer patients

2020 ◽  
Vol 18 (9) ◽  
pp. 2220-2231 ◽  
Author(s):  
Marina Marchetti ◽  
Cinzia Giaccherini ◽  
Giovanna Masci ◽  
Cristina Verzeroli ◽  
Laura Russo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Thrombin Generation ◽  
Early Recurrence ◽  
Breast Cancer Patients

Response rate to neoadjuvant chemotherapy measured on imaging predicts early recurrence and death in breast cancer patients with lymph node involvements

2011 ◽  
Vol 52 (3) ◽  
pp. 241-246 ◽  
Author(s):  
Takeshi Nagashima ◽  
Masahiro Sakakibara ◽  
Masami Kadowaki ◽  
Tiberiu Hiroshi Suzuki ◽  
Jissei Yokomizo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Neoadjuvant Chemotherapy ◽  
Cancer Patients ◽  
Response Rate ◽  
Early Recurrence ◽  
Breast Cancer Patients

Identification of Breast Cancer Patients With High Risk of Early Recurrence After Radical Mastectomy. I. Description of Study2

1974 ◽  
Vol 53 (3) ◽  
pp. 603-607 ◽  
Author(s):  
Gilbert H. Friedell ◽  
Ira S. Goldenberg ◽  
Ihor J. Masnyk ◽  
C. A. McMahan ◽  
Robert G. Ravdin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
High Risk ◽  
Cancer Patients ◽  
Radical Mastectomy ◽  
Early Recurrence ◽  
Breast Cancer Patients

Impact of Chemotherapy on Thrombin Generation and on the Protein C Pathway in Breast Cancer Patients

2009 ◽  
Vol 37 (2-4) ◽  
pp. 88-97 ◽  
Author(s):  
Som D. Mukherjee ◽  
Laura L. Swystun ◽  
Nigel Mackman ◽  
Jian-Guo Wang ◽  
Gregory Pond ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Protein C ◽  
Thrombin Generation ◽  
Breast Cancer Patients

Platelet-derived microparticles and coagulation activation in breast cancer patients

2008 ◽  
Vol 100 (10) ◽  
pp. 663-669 ◽  
Author(s):  
Bettina Toth ◽  
Susanne Liebhardt ◽  
Kerstin Steinig ◽  
Nina Ditsch ◽  
Andreas Rank ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Endothelial Cells ◽  
Cancer Patients ◽  
Tumor Size ◽  
Thrombin Generation ◽  
Annexin V ◽  
Distant Metastases ◽  
Breast Cancer Patients ◽  
Cancer Associated Thrombosis

SummaryIn the mid 1800s Trousseau observed cancer-associated thrombosis, of which the underlying pathogenesis still remains unknown. We performed a prospective study on platelet-derived microparticles (PMP) and their procoagulant potential in breast cancer patients. Fifty-eight breast cancer patients and 13 women with benign breast tumors were included in the study. Microparticles (MP) were examined by electron microscopy and FACS analysis using labels for annexinV (total numbers), CD61 (PMP), CD62P and CD63 (activated platelets), CD62E (endothelial cells), CD45 (leukocytes) as well as CD142 (tissue factor). Prothrombin fragment 1+2 (F1+2) and thrombin generation were measured as blood coagulation markers. Numbers of annexin V+-MP were highest in breast cancer patients with larger tumor size (T2; median = 5,637×106/l; range = 2,852–8,613) and patients with distant metastases (M1; median = 6,102×106/l; range = 3,350–7,445), and differed significantly from patients with insitu tumor (Tis; median = 3,220×106/l; range = 2,277–4,124; p = 0.019), small tumor size (T1; median = 3,281×106/l; range 2,356–4,861; p = 0.043) and women with benign breast tumor (median = 4,108×106/l; range = 2,530–4,874; p = 0.040). A total of 82.3% of MP were from platelets,14.6 % from endothelial cells and 0.3% from leukocytes. Less than 10% of PMP showed degranulation markers. Larger tumor size (T2) and metastases correlated with high counts of PMP and with highest F1+2 levels. Since prothrombin levels and thrombin generation did not parallel MP levels, we speculate that MP act in the microenvironment of tumor tissue and may thus not be an exclusive parameter reflecting in-vivo procoagulant activity.

Prognosis and predictor role of PD-L1 expression in breast cancer patients between early recurrence and late recurrence.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. e23241-e23241
Author(s):  
Tao Qin ◽  
Xin-ke Zhang ◽  
Jiabin Lu ◽  
Cong Xue ◽  
Wen Xia ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Late Recurrence ◽  
Early Recurrence ◽  
Breast Cancer Patients
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