scholarly journals RE: The prothrombin time ratio is not a more effective marker for evaluating sepsis‐induced coagulopathy than fibrin‐related markers: Response to the Letter‐to‐the‐Editor by Dr Wada

2020 ◽  
Vol 18 (6) ◽  
pp. 1507-1509
Author(s):  
Toshiaki Iba ◽  
Jerrold H. Levy ◽  
Theodore E. Warkentin ◽  
Jecko Thachil ◽  
Tom Poll ◽  
...  
Keyword(s):  
Prothrombin Time ◽  
Time Ratio ◽  
Letter To The Editor ◽  
Prothrombin Time Ratio

scholarly journals Complications of warfarin therapy monitored by the international normalized ratio versus the prothrombin time ratio

1995 ◽  
Vol 18 (2) ◽  
pp. 80-82 ◽  
Author(s):  
Thomas C. Andrews ◽  
David W. Peterson ◽  
Dennis Doeppenschmidt ◽  
Jeff S. Foster ◽  
Michael J. Lucca ◽  
...  
Keyword(s):  
Prothrombin Time ◽  
Warfarin Therapy ◽  
International Normalized Ratio ◽  
Time Ratio ◽  
Ratio Versus ◽  
Prothrombin Time Ratio

Preoperative direct bilirubin to prothrombin time ratio index to prevent liver failure after minor hepatectomy

2016 ◽  
Vol 23 (12) ◽  
pp. 763-770 ◽  
Author(s):  
Takaki Furuyama ◽  
Atsushi Kudo ◽  
Satoshi Matsumura ◽  
Yusuke Mitsunori ◽  
Arihiro Aihara ◽  
...  
Keyword(s):  
Liver Failure ◽  
Prothrombin Time ◽  
Direct Bilirubin ◽  
Time Ratio ◽  
Prothrombin Time Ratio

Influence of plasma volumetric errors on the prothrombin time ratio and International Sensitivity Index

1997 ◽  
Vol 8 (7) ◽  
pp. 431-436 ◽  
Author(s):  
A. M. H. P. van den Besselaar ◽  
J. Meeuwisse-Braun ◽  
H. Schaefer-van Mansfeld ◽  
E. Witteveen ◽  
C. van Rijn
Keyword(s):  
Prothrombin Time ◽  
Sensitivity Index ◽  
Time Ratio ◽  
Volumetric Errors ◽  
International Sensitivity Index ◽  
Prothrombin Time Ratio

scholarly journals Coagulopathy Induced by Veno-Arterial Extracorporeal Membrane Oxygenation Is Associated With a Poor Outcome in Patients With Out-of-Hospital Cardiac Arrest

2021 ◽  
Vol 8 ◽  
Author(s):  
Takumi Tsuchida ◽  
Takeshi Wada ◽  
Satoshi Gando
Keyword(s):  
Cardiac Arrest ◽  
Propensity Score ◽  
Extracorporeal Membrane Oxygenation ◽  
Prothrombin Time ◽  
Propensity Score Matching ◽  
Poor Prognosis ◽  
Strongly Correlated ◽  
Time Ratio ◽  
Va Ecmo ◽  
Prothrombin Time Ratio

Background: In recent years, the use of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) in patients with cardiopulmonary arrest who do not respond to conventional resuscitation, has increased. However, despite the development of VA-ECMO, the outcomes of resuscitated patients remain poor. The poor prognosis may be attributed to deterioration owing to the post-cardiac arrest syndrome (PCAS); this includes the systemic inflammatory response and coagulation activation caused by the extracorporeal circulation (VA-ECMO circuit) itself. This study aimed to evaluate the coagulofibrinolytic changes caused by VA-ECMO and to identify predictive factors of poor prognosis.Methods: We analyzed 151 cases of PCAS with witnessed cardiac arrest. As biomarkers, platelet counts, prothrombin time ratio, fibrin/fibrinogen degradation products, fibrinogen, antithrombin, and lactate were recorded from blood samples from the time of delivery to the third day of hospitalization. The maximum (max) and minimum (min) values of each factor during the study period were calculated. To evaluate the impact of VA-ECMO on patients with PCAS, we performed propensity score matching between the patients who received and did not receive VA-ECMO. Sub-analysis was performed for the group with VA-ECMO.Results: There were significant differences in all baseline characteristics and demographics except the time from detection to hospital arrival, percentage of cardiopulmonary resuscitations (CPR) by witnesses, and the initial rhythm between the groups. Propensity score matching adjusted for prehospital factors demonstrated that the patients who received VA-ECMO developed significantly severe coagulation disorders. In a sub-analysis, significant differences were noted in the prothrombin time ratio min, fibrinogen max, antithrombin max, and lactate min between survivors and non-survivors. In particular, the prothrombin time ratio min and antithrombin max were strongly correlated with poor outcome.Conclusion: In the present study, significant coagulopathy was observed in patients who received VA-ECMO for CPR. In particular, in patients receiving VA-ECMO, the minimum prothrombin time ratio and maximum antithrombin by day 3 of hospitalization were strongly correlated with poor outcomes. These results suggest that VA-ECMO-induced coagulopathy can be a promising therapeutic target for patients resuscitated by VA-ECMO.

Prothrombin Time Ratio Is Reduced by Magnesium Contamination in Evacuated Blood Collection Tubes

2001 ◽  
Vol 85 (04) ◽  
pp. 647-650 ◽  
Author(s):  
W. van Dam ◽  
A. Sturk ◽  
R. M. Bertina ◽  
A. M. H. P. van den Besselaar
Keyword(s):  
Prothrombin Time ◽  
Sodium Citrate ◽  
Oral Anticoagulant Therapy ◽  
Blood Collection ◽  
Magnesium Ions ◽  
Time Ratio ◽  
Normal Plasma ◽  
The Mean ◽  
Blood Collection Tubes ◽  
Prothrombin Time Ratio

SummaryMagnesium ions were detected in sodium citrate solutions in several lots of evacuated blood collection tubes. The mean concentrations ranged between 1.3 and 1.6 mmol/L. Magnesium was also present in the rubber stoppers of the blood collection tubes and could be leached into the citrate solution. It was shown that magnesium added to citrated plasma shortened the prothrombin time of both coumarin and normal plasma. The effect of magnesium was relatively greater on coumarin than on normal plasma resulting in reduced prothrombin time ratio. Shortening of the prothrombin time was also observed when magnesium chloride was added to dialysed plasma, i.e., in the absence of citrate. These results indicate that magnesium contamination can interfere with accurate INR determination in the control of oral anticoagulant therapy.

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