scholarly journals Plasma levels of mannose‐binding lectin and future risk of venous thromboembolism

2019 ◽  
Vol 17 (10) ◽  
pp. 1661-1669 ◽  
Author(s):  
Robin A. Liang ◽  
Ina I. Høiland ◽  
Thor Ueland ◽  
Pål Aukrust ◽  
Omri Snir ◽  
...  
Keyword(s):  
Venous Thromboembolism ◽  
Plasma Levels ◽  
Mannose Binding Lectin ◽  
Mannose Binding ◽  
Future Risk ◽  
Binding Lectin

scholarly journals Characterization of mannose-binding lectin plasma levels and genetic polymorphisms in HIV-1-infected individuals

2011 ◽  
Vol 44 (1) ◽  
pp. 1-3 ◽  
Author(s):  
Antonio Carlos Rosário Vallinoto ◽  
Felipe Bonfim Freitas ◽  
Isabella Guirelli ◽  
Luiz Fernando Almeida Machado ◽  
Vânia Nakauth Azevedo ◽  
...  
Keyword(s):  
Viral Load ◽  
Gene Polymorphism ◽  
Plasma Levels ◽  
Plasma Viral Load ◽  
Mannose Binding Lectin ◽  
Wild Allele ◽  
Number Of Patients ◽  
Mannose Binding ◽  
Binding Lectin ◽  
Hiv 1

INTRODUCTION: The present study investigated the association between mannose-binding lectin (MBL) gene polymorphism and serum levels with infection by HIV-1. METHODS: Blood samples (5mL) were collected from 97 HIV-1-infected individuals resident in Belém, State of Pará, Brazil, who attended the Special Outpatient Unit for Infections and Parasitic Diseases (URE-DIPE). CD4+ T-lymphocyte count and plasma viral load were quantified. A 349bp fragment of exon 1 of the MBL was amplified via PCR, using genomic DNA extracted from controls and HIV-1-infected individuals, following established protocols. MBL plasma levels of the patients were quantified using an enzyme immunoassay kit. RESULTS: Two alleles were observed: MBL*O, with a frequency of 26.3% in HIV-1-infected individuals; and the wild allele MBL*A (73.7%). Similar frequencies were observed in the control group (p > 0.05). Genotype frequencies were distributed according to the Hardy-Weinberg equilibrium in both groups. Mean MBL plasma levels varied by genotype, with statistically significant differences between the AA and AO (p < 0.0001), and AA and OO (p < 0.001) genotypes, but not AO and OO (p = 0.17). Additionally, CD4+ T-lymphocytes and plasma viral load levels did not differ significantly by genotype (p > 0.05). CONCLUSIONS: The results of this study do not support the hypothesis that MBL gene polymorphism or low plasma MBL concentrations might have a direct influence on HIV-1 infection, although a broader study involving a large number of patients is needed.

scholarly journals Role for Mannose Binding Lectin in the Prevention of Mycoplasma Infection

2005 ◽  
Vol 73 (8) ◽  
pp. 5238-5240 ◽  
Author(s):  
Renata M. J. Hamvas ◽  
Marina Johnson ◽  
Arine M. Vlieger ◽  
Clare Ling ◽  
Andrea Sherriff ◽  
...  
Keyword(s):  
Plasma Levels ◽  
Antibody Deficiency ◽  
Mannose Binding Lectin ◽  
Primary Antibody ◽  
Mycoplasma Infection ◽  
Primary Antibody Deficiency ◽  
Mannose Binding ◽  
Exon 1 ◽  
Binding Lectin

ABSTRACT Polymorphisms in exon 1 of the MBL-2 gene, resulting in reduced plasma levels of mannose binding lectin, were significantly overrepresented in 23 patients with primary antibody deficiency and culture-proven mycoplasma infections (P = 0.0038). This association persisted with the inclusion of a further nine suspected (doxycycline-responsive) cases (P = 0.0087). The lectin was shown to bind to three strains of mycoplasma.

scholarly journals Associations between complement pathways activity, mannose-binding lectin, and odds of unprovoked venous thromboembolism

2018 ◽  
Vol 169 ◽  
pp. 50-56 ◽  
Author(s):  
Ina Isabella Høiland ◽  
Robin Amanda Liang ◽  
Kristian Hindberg ◽  
Nadezhda Latysheva ◽  
Ole-Lars Brekke ◽  
...  
Keyword(s):  
Venous Thromboembolism ◽  
Mannose Binding Lectin ◽  
Mannose Binding ◽  
Binding Lectin ◽  
Complement Pathways

scholarly journals Mannose‐Binding Lectin Plasma Levels and Gene Polymorphisms inPlasmodium falciparumMalaria

1998 ◽  
Vol 178 (4) ◽  
pp. 1221-1224 ◽  
Author(s):  
Adrian J. F. Luty ◽  
Jürgen F. J. Kun ◽  
Peter G. Kremsner
Keyword(s):  
Plasma Levels ◽  
Gene Polymorphisms ◽  
Mannose Binding Lectin ◽  
Mannose Binding ◽  
Binding Lectin
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