scholarly journals Recommendations for clinical laboratory testing of activated protein C resistance; communication from the SSC of the ISTH

2019 ◽  
Vol 17 (9) ◽  
pp. 1555-1561 ◽  
Author(s):  
Gary W. Moore ◽  
Elizabeth M. Van Cott ◽  
Jacqueline A. Cutler ◽  
Michael J. Mitchell ◽  
Dorothy M. Adcock ◽  
...  
Keyword(s):  
Laboratory Testing ◽  
Protein C ◽  
Clinical Laboratory ◽  
Activated Protein C ◽  
Activated Protein C Resistance ◽  
Clinical Laboratory Testing

Activated Protein C Resistance, the Factor V Leiden Mutation, and a Laboratory Testing Algorithm

2002 ◽  
Vol 126 (5) ◽  
pp. 577-582 ◽  
Author(s):  
Elizabeth M. Van Cott ◽  
Britt L. Soderberg ◽  
Michael Laposata
Keyword(s):  
Laboratory Testing ◽  
Protein C ◽  
Activated Protein C ◽  
Factor V Leiden ◽  
Protein S ◽  
Factor V ◽  
Activated Protein C Resistance ◽  
Factor V Leiden Mutation ◽  
Increased Risk ◽  
Testing Algorithm

Abstract Objectives.—To present the current understanding of factor V Leiden and activated protein C resistance, and to propose a laboratory testing algorithm. Data Sources.—Publications on MEDLINE with the terms factor V Leiden or activated protein C resistance through mid 2001, as well as publications in the authors' files, were screened for inclusion in this report. Study Selection.—Original studies that report a novel finding on testing or clinical features of activated protein C resistance or factor V Leiden are included. Data Extraction.—The novel or key findings from the selected studies are analyzed. Data Synthesis.—Protein C and protein S are the integral components of an anticoagulation pathway that limits fibrinogen conversion to fibrin through the degradation of factors Va and VIIIa. When factor Va is resistant to degradation by activated protein C, this anticoagulation pathway does not operate properly, and patients have an increased risk for thrombosis. This report describes the protein C/protein S pathway, the significance of activated protein C resistance and the factor V Leiden mutation, and the clinical testing used to detect activated protein C resistance and the factor V Leiden mutation. A proposed laboratory testing algorithm is also provided. Conclusions.—Factor V Leiden is a risk factor for venous thrombosis and it is particularly common in white populations. A laboratory testing algorithm is proposed.

Coagulation Factor V Leiden Mutation Was Detected in the Patients with Activated Protein C Resistance in Thailand

1998 ◽  
Vol 80 (08) ◽  
pp. 344-345 ◽  
Author(s):  
Pasra Arnutti ◽  
Motofumi Hiyoshi ◽  
Wichai Prayoonwiwat ◽  
Oytip Nathalang ◽  
Chamaiporn Suwanasophon ◽  
...  
Keyword(s):  
Protein C ◽  
Activated Protein C ◽  
Factor V Leiden ◽  
Coagulation Factor ◽  
Factor V ◽  
Activated Protein C Resistance ◽  
Factor V Leiden Mutation ◽  
Coagulation Factor V

Influence of Plasma Platelets on Activated Protein C Resistance Assay

1995 ◽  
Vol 74 (03) ◽  
pp. 993-994 ◽  
Author(s):  
Johannes Sidelmann ◽  
Jørgen Gram ◽  
Ole Dyg Pedersen ◽  
Jørgen Jespersen
Keyword(s):  
Protein C ◽  
Activated Protein C ◽  
Activated Protein C Resistance

Activated protein C resistance phenotype in patients with antiphospholipid antibodies

1997 ◽  
Vol 130 (2) ◽  
pp. 202-208 ◽  
Author(s):  
Justo Aznar ◽  
Piedad Villa ◽  
Francisco España ◽  
Amparo Estellés ◽  
Salvador Grancha ◽  
...  
Keyword(s):  
Antiphospholipid Antibodies ◽  
Protein C ◽  
Activated Protein C ◽  
Activated Protein C Resistance ◽  
Resistance Phenotype
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