scholarly journals Revisiting the role of therapeutic plasma exchange in the management of catastrophic antiphospholipid syndrome

2019 ◽  
Vol 17 (7) ◽  
pp. 1179-1180 ◽  
Author(s):  
Alexis R. Peedin ◽  
Julie K. Karp
Keyword(s):  
Plasma Exchange ◽  
Antiphospholipid Syndrome ◽  
Therapeutic Plasma Exchange ◽  
Catastrophic Antiphospholipid Syndrome

Recovery from catastrophic antiphospholipid syndrome by a plasma exchange procedure: report of four cases and review of the literature

2009 ◽  
Vol 8 (4) ◽  
pp. 297-301 ◽  
Author(s):  
Maria Bortolati ◽  
Piero Marson ◽  
Fabrizio Fabris ◽  
Vittorio Pengo ◽  
Myriam Facchinetti ◽  
...  
Keyword(s):  
Plasma Exchange ◽  
Antiphospholipid Syndrome ◽  
Review Of The Literature ◽  
Catastrophic Antiphospholipid Syndrome

The role of infectious diseases in the catastrophic antiphospholipid syndrome

2015 ◽  
Vol 14 (11) ◽  
pp. 1066-1071 ◽  
Author(s):  
M. Garcia-Carrasco ◽  
C. Mendoza-Pinto ◽  
S. Macias-Diaz ◽  
F. Vazquez de Lara ◽  
I. Etchegaray-Morales ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
Antiphospholipid Syndrome ◽  
Catastrophic Antiphospholipid Syndrome

scholarly journals Critical Care COVID-19 Patient with a Picture of Thrombotic Thrombocytopenic Purpura

2020 ◽  
Author(s):  
Rehab AL-Ansari ◽  
Mohanad Bakkar ◽  
Leena Abdalla ◽  
Khaled Sewify
Keyword(s):  
Mechanical Ventilation ◽  
Critical Care ◽  
Plasma Exchange ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Kidney Injury ◽  
Therapeutic Plasma Exchange ◽  
Thrombocytopenic Purpura ◽  
Threatening Condition ◽  
Life Threatening

Background: Thrombotic thrombocytopenic purpura (TTP) is an uncommon haematological disease which can occur at any age and may present with COVID-19. This case describes a COVID-19 complication associated with a presentation resembling TTP. Case description: A 51-year-old man who had received a kidney transplant and was on immunosuppressant medication, was admitted to a critical care unit with severe COVID-19 pneumonia/acute respiratory distress syndrome (ARDS) which required intubation, mechanical ventilation and inotropic support. The course was complicated by the classic pentad of thrombocytopenia, intravascular haemolysis, acute kidney injury, neurological symptoms and fever, which prompted the diagnosis of probable TTP. After five sessions of therapeutic plasma exchange, the patient’s general status improved, he was weaned off mechanical ventilation and his renal panel and haemolytic markers normalized. Conclusion: TTP is a life-threatening condition which requires urgent management with therapeutic plasma exchange. This case highlights some possible complications of COVID-19 generally and in immunocompromised patients specifically. The potential role of plasma exchange in COVID-19 patients without a positive diagnosis of TTP (the so-called ‘TTP resembling presentation’) is an area of further research.

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