scholarly journals C-reactive protein induces expression of tissue factor and plasminogen activator inhibitor-1 and promotes fibrin accumulation in vein grafts

2014 ◽  
Vol 12 (10) ◽  
pp. 1667-1677 ◽  
Author(s):  
Y. Ji ◽  
P. M. Fish ◽  
T. L. Strawn ◽  
A. W. Lohman ◽  
J. Wu ◽  
...  
Keyword(s):  
Tissue Factor ◽  
Plasminogen Activator ◽  
Plasminogen Activator Inhibitor ◽  
C Reactive Protein ◽  
Plasminogen Activator Inhibitor 1 ◽  
Vein Grafts ◽  
Reactive Protein ◽  
Activator Inhibitor

scholarly journals Defining the Proinflammatory Phenotype Using High Sensitive C-Reactive Protein Levels as the Biomarker

2005 ◽  
Vol 90 (8) ◽  
pp. 4549-4554 ◽  
Author(s):  
Sridevi Devaraj ◽  
Grant O’Keefe ◽  
Ishwarlal Jialal
Keyword(s):  
Cell Adhesion ◽  
Plasminogen Activator ◽  
Body Mass ◽  
Whole Blood ◽  
Plasminogen Activator Inhibitor ◽  
C Reactive Protein ◽  
Plasminogen Activator Inhibitor 1 ◽  
Reactive Protein ◽  
Tnf Α ◽  
Activator Inhibitor

Context: Inflammation is pivotal in atherosclerosis. The prototypic marker of inflammation is C-reactive protein (CRP). Numerous studies have confirmed that high CRP levels in normal volunteers predict cardiovascular events. Objective: The objective of this study was to define proximal and associated abnormalities of the proinflammatory phenotype using CRP levels as the biomarker. Design and Subjects: Two groups of normal, healthy subjects, selected by stringent criteria from an initial cohort of 252, were studied over the period of 12 months. Group 1 included subjects with consistently low CRP (<0.004 μm or <0.5 mg/liter; low CRP group; n = 15). Group 2 included subjects with consistently high CRP (>2.0 or >0.016 μm to <10 mg/liter or <0.085 μm; high CRP group; n = 13). Main Outcome Measures: Fasting blood (50 ml) was obtained, and the following parameters were assayed: high sensitivity CRP, fibrinogen, lipid profile, insulin, whole blood cytokines after stimulation with lipopolysaccharide (LPS; 100 ng/ml for 24 h), soluble cell adhesion molecules, plasminogen activator inhibitor-1, CD40, CD40 ligand, leptin, adiponectin, monocyte chemoattractant protein-1, IL-8, matrix metalloproteinase-3 (MMP-3), and MMP-9. Genomic DNA was obtained from peripheral blood leukocytes, and the TNF-α −308 genotype was determined. Results: The median CRP levels were 0.0018 μm (0.21 mg/liter) and 0.031 μm (3.7 mg/liter) for the low and high groups, respectively. High CRP subjects were older and had significantly higher body mass indexes, triglycerides, insulin, homeostasis model assessment, and leptin levels compared with low CRP subjects. The markers of inflammation, plasminogen activator inhibitor-1, MMP-9, fibrinogen, and vascular cell adhesion molecule-1 levels were significantly higher in the high compared with the low CRP group. LPS-stimulated levels of whole blood IL-1β, IL-6, and TNF were significantly higher, and IL-4 levels were significantly lower in the high CRP group. After age- and body mass index-adjusted analysis of covariance, only plasma MMP-9 levels and LPS-stimulated whole blood IL-1β and TNF levels were significantly higher in the high CRP group. The frequency of the rare A allele at TNF-α −308 was equivalent in high and low CRP groups. Conclusions: A phenotype characterized by increased plasma inflammatory mediators as well as increased LPS-stimulated whole blood TNF-α and IL-1β levels is associated with high plasma CRP levels. This systemic inflammatory phenotype may contribute to vascular inflammation or may reflect inflammation in vessels or at other sites.

scholarly journals Melatonin Levels in Children with Obesity Are Associated with Metabolic Risk and Inflammatory Parameters

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3629
Author(s):  
Marie Gombert ◽  
Vanessa Martin-Carbonell ◽  
Gonzalo Pin-Arboledas ◽  
Joaquín Carrasco-Luna ◽  
Álvaro Carrasco-García ◽  
...  
Keyword(s):  
Plasminogen Activator ◽  
Sleep Duration ◽  
Tumor Necrosis ◽  
High Sensitivity ◽  
Plasminogen Activator Inhibitor ◽  
Mitochondrial Activity ◽  
C Reactive Protein ◽  
Plasminogen Activator Inhibitor 1 ◽  
Reactive Protein ◽  
Activator Inhibitor

Melatonin, the hormone of circadian rhythm regulation, is involved in the modulation of mitochondrial activity through its antioxidant and anti-inflammatory properties. Alteration of circadian rhythms such as sleep is related to obesity and metabolic pathogenesis in adulthood, but studies during childhood are scarce. The present study investigated the association of melatonin with metabolic and inflammatory markers in children with (n = 113) and without obesity (n = 117). Melatonin was measured in saliva four and two hours before bedtime, and after one hour of sleep. Cardiometabolic factors, high sensitivity C-reactive protein, immune markers (monocyte chemoattractant protein-1, plasminogen activator inhibitor-1, tumor necrosis α and interferon-γ), leptin and ghrelin were determined. Sleep duration was recorded by a questionnaire. The melatonin level at 1 h after sleep was found to be increased more than twofold in children with obesity (90.16 (57.16–129.16) pg/mL) compared to controls (29.82 (19.05–61.54) pg/mL, p < 0.001) and was related to fat mass (rho = 0.294, p < 0.001); melatonin levels at 1 h after sleep were inversely correlated with high-density lipoprotein cholesterol. Positive correlation was found with apolipoprotein B, adipokines, high sensitivity C-reactive protein, plasminogen activator inhibitor-1 and tumor necrosis factor-α. Shorter sleep duration and earlier waking times were recorded in children with obesity. In conclusion, melatonin in children with obesity appears to be involved in the global metabolic and inflammatory alteration of this condition.

scholarly journals Plasminogen activator inhibitor-1 inhibits factor VIIa bound to tissue factor

2011 ◽  
Vol 9 (3) ◽  
pp. 531-539 ◽  
Author(s):  
P. SEN ◽  
A. A. KOMISSAROV ◽  
G. FLOROVA ◽  
S. IDELL ◽  
U. R. PENDURTHI ◽  
...  
Keyword(s):  
Tissue Factor ◽  
Plasminogen Activator ◽  
Factor Viia ◽  
Plasminogen Activator Inhibitor ◽  
Plasminogen Activator Inhibitor 1 ◽  
Activator Inhibitor
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