scholarly journals Thrombolytic therapy or surgery for valve prosthesis thrombosis: systematic review and meta-analysis

2014 ◽  
Vol 12 (8) ◽  
pp. 1218-1228 ◽  
Author(s):  
F. M. Castilho ◽  
M. R. De Sousa ◽  
A. L. P. Mendonça ◽  
A. L. P. Ribeiro ◽  
F. M. Cáceres-Lóriga
Keyword(s):  
Systematic Review ◽  
Thrombolytic Therapy ◽  
Meta Analysis ◽  
Valve Prosthesis

Mitral valve prosthesis choice in patients <70 years: A systematic review and meta‐analysis of 20 219 patients

2020 ◽  
Vol 35 (4) ◽  
pp. 818-825 ◽  
Author(s):  
Bobby Yanagawa ◽  
Jessica Lee ◽  
Maral Ouzounian ◽  
Akshay Bagai ◽  
Asim Cheema ◽  
...  
Keyword(s):  
Systematic Review ◽  
Mitral Valve ◽  
Meta Analysis ◽  
Valve Prosthesis ◽  
Mitral Valve Prosthesis

Thrombolytic therapy for ischaemic stroke in patients using warfarin: a systematic review and meta-analysis

2012 ◽  
Vol 83 (5) ◽  
pp. 537-540 ◽  
Author(s):  
Irene Miedema ◽  
Gert-Jan Luijckx ◽  
Jacques De Keyser ◽  
Marcus Koch ◽  
Maarten Uyttenboogaart
Keyword(s):  
Systematic Review ◽  
Thrombolytic Therapy ◽  
Ischaemic Stroke ◽  
Meta Analysis

scholarly journals Systemic thrombolytic therapy for acute pulmonary embolism: a systematic review and meta-analysis

2014 ◽  
Vol 36 (10) ◽  
pp. 605-614 ◽  
Author(s):  
Christophe Marti ◽  
Gregor John ◽  
Stavros Konstantinides ◽  
Christophe Combescure ◽  
Olivier Sanchez ◽  
...  
Keyword(s):  
Systematic Review ◽  
Pulmonary Embolism ◽  
Thrombolytic Therapy ◽  
Acute Pulmonary Embolism ◽  
Meta Analysis ◽  
Systemic Thrombolytic Therapy

Abstract 1: Thrombolytic Therapy for ‘Wake-Up Stroke’ - A Systematic Review and Meta-Analysis

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Brian C Mac Grory ◽  
Ian J Saldanha ◽  
Eva Mistry ◽  
Sven Poli ◽  
Marek Sykora ◽  
...  
Keyword(s):  
Systematic Review ◽  
Thrombolytic Therapy ◽  
Functional Recovery ◽  
Meta Analysis ◽  
Risk Of Bias ◽  
Secondary Outcome ◽  
Stroke Group ◽  
Observational Cohort ◽  
Symptomatic Intracranial Hemorrhage ◽  
Selection Algorithms

Introduction: Twenty-five percent of strokes are detected upon awakening (‘wake-up strokes’; WUS) and are not amenable to thrombolytic therapy via existing time-based treatment approaches. We performed a systematic review and meta-analysis of the efficacy and safety of thrombolysis in patients with WUS using imaging-based selection algorithms. Methods: This systematic review was registered through PROSPERO (CRD42020151552). We searched PubMed, Web of Science, and Scopus between January 1, 2006 and April 30, 2020 for controlled trials and observational cohort studies (prospective or retrospective), in which adults with WUS were administered thrombolysis after MR- or CT-based imaging. Our primary outcome was recovery (mRS 0-2) at 90 days and our secondary outcome was symptomatic intracranial hemorrhage (sICH). We assessed risk of bias using the Cochrane Risk of Bias 2.0 and ROBINS-I tools. Results: We included 16 studies that enrolled a total of 14,017 patients. Sixty-one percent of patients receiving tPA achieved a functional recovery at 90 days (95% CI: 51% to 70%; 12 studies), with a relative risk (RR) of recovery of 1.21 compared with patients not receiving tPA (95% CI 1.01 to 1.46; 4 comparative studies). As shown in Figure 1, 3% of patients receiving tPA in the treated WUS stroke group experienced sICH, an RR of 4.0 (95% CI 2.85-5.61) compared with patients not receiving tPA. On meta-regression, advancing age was negatively associated with the RR of recovery (p<0.001) and there was a trend that increased NIHSS was associated with the RR of sICH (p=0.083). Conclusions: In patients with WUS, thrombolysis is associated with functional recovery and with a low risk of sICH. This risk is comparable to the sICH rate from tPA-treatment of stroke utilizing the standard protocol timeframe (2.4% in ECASS III). Thrombolysis should be considered in the treatment of WUS in patients with favorable neuroimaging.

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