scholarly journals Sleep patterns and insomnia in a large population‐based study of middle‐aged and older adults: The Tromsø study 2015–2016

2020 ◽  
Author(s):  
Børge Sivertsen ◽  
Ståle Pallesen ◽  
Oddgeir Friborg ◽  
Kristian Bernhard Nilsen ◽  
Øystein Kvåle Bakke ◽  
...  
Keyword(s):  
Older Adults ◽  
Large Population ◽  
Population Based ◽  
Middle Aged ◽  
Sleep Patterns ◽  
Population Based Study

Self-perceived coping resources of middle-aged and older adults – results of a large population-based study

2016 ◽  
Vol 21 (12) ◽  
pp. 1303-1309 ◽  
Author(s):  
Friederike H. Boehlen ◽  
Wolfgang Herzog ◽  
Dieter Schellberg ◽  
Imad Maatouk ◽  
Kai-Uwe Saum ◽  
...  
Keyword(s):  
Older Adults ◽  
Large Population ◽  
Population Based ◽  
Coping Resources ◽  
Middle Aged ◽  
Population Based Study

Control preferences in treatment decisions among older adults — Results of a large population-based study

2016 ◽  
Vol 86 ◽  
pp. 28-33 ◽  
Author(s):  
Sabine Lechner ◽  
Wolfgang Herzog ◽  
Friederike Boehlen ◽  
Imad Maatouk ◽  
Kai-Uwe Saum ◽  
...  
Keyword(s):  
Older Adults ◽  
Large Population ◽  
Treatment Decisions ◽  
Population Based ◽  
Population Based Study

Evidence for underuse and overuse of antidepressants in older adults: Results of a large population‐based study

2019 ◽  
Vol 34 (4) ◽  
pp. 539-547 ◽  
Author(s):  
Friederike H. Boehlen ◽  
Julia Freigofas ◽  
Wolfgang Herzog ◽  
Andreas D. Meid ◽  
Kai‐Uwe Saum ◽  
...  
Keyword(s):  
Older Adults ◽  
Large Population ◽  
Population Based ◽  
Population Based Study

scholarly journals Sexuality Among Middle-Aged and Older Adults With Diagnosed and Undiagnosed Diabetes: A national, population-based study

Diabetes Care ◽  
2010 ◽  
Vol 33 (10) ◽  
pp. 2202-2210 ◽  
Author(s):  
S. T. Lindau ◽  
H. Tang ◽  
A. Gomero ◽  
A. Vable ◽  
E. S. Huang ◽  
...  
Keyword(s):  
Older Adults ◽  
Population Based ◽  
Undiagnosed Diabetes ◽  
Middle Aged ◽  
Population Based Study ◽  
National Population

Thrombotic risk determined by protein C receptor (PROCR) variants among middle-aged and older adults: a population-based cohort study

2022 ◽  
Author(s):  
Eric Manderstedt ◽  
Christer Hallden ◽  
Christina Lind-Hallden ◽  
Johan Elf ◽  
peter svensson ◽  
...  
Keyword(s):  
Older Adults ◽  
Protein C ◽  
Association Studies ◽  
Large Population ◽  
Missense Variant ◽  
Population Based ◽  
Genome Wide Association Studies ◽  
Loss Of Function ◽  
Middle Aged ◽  
Thrombotic Risk

Background: The protein C (PC) anticoagulant system has a key role in maintaining hemostatic balance. One missense (Ser219Gly) variant in the protein C receptor (PROCR) was associated with venous thromboembolism (VTE) in genome-wide association studies. Objectives: This study aimed to determine the thrombotic risk of rare and common PROCR variants in a large population-based cohort of middle-aged and older adults. Patients/Methods: The exonic sequence of PROCR was analyzed for the Ser219Gly variant and other qualifying variants in 28,794 subjects (born 1923-1950, 60% women) without previous VTE, who participated in the Malmö Diet and Cancer study (1991-1996). Incidence of VTE was followed up until 2018. Qualifying variants were defined as loss-of-function or non-benign (PolyPhen-2) missense variants with minor allele frequencies (MAF) < 0.1%. Results: Resequencing identified 36 PROCR variants in the study population (26,210 non-VTE exomes and 2584 VTE exomes), 11 synonymous, 22 missense and three loss-of-function variants. Kaplan-Meier analysis of the known Ser219Gly variant (rs867186) showed that homozygosity for this variant increased the risk of disease whereas heterozygosity showed no effect. Cox multivariate regression analysis revealed an adjusted hazard ratio of 1.5 (95%CI 1.1-2.0). Fifteen rare variants were classified as qualifying and were included in collapsing analysis (burden test and SKAT-O). They did not contribute to risk. However, a Arg113Cys missense variant (rs146420040; MAF=0.004) showed an increased VTE risk (HR=1.3; 95%CI 1.0-1.9). Conclusions: Homozygosity for the Ser219Gly variant and a previously identified functional PROCR variant (Arg113Cys) was associated with VTE. Other variants did not contribute to VTE.

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