scholarly journals Targeted recombination in active populations as a new mouse genetic model to study sleep‐active neuronal populations: Demonstration that Lhx6+ neurons in the ventral zona incerta are activated during paradoxical sleep hypersomnia

2020 ◽  
Vol 29 (6) ◽  
Author(s):  
Hyun‐Sook Lee ◽  
Risa Yamazaki ◽  
Dianru Wang ◽  
Sébastien Arthaud ◽  
Patrice Fort ◽  
...  
Keyword(s):  
Genetic Model ◽  
Paradoxical Sleep ◽  
Zona Incerta ◽  
Neuronal Populations ◽  
Targeted Recombination ◽  
Mouse Genetic Model ◽  
Mouse Genetic

Spontaneous fracture (sfx): a mouse genetic model of defective peripubertal bone formation

Bone ◽  
2000 ◽  
Vol 27 (5) ◽  
pp. 619-626 ◽  
Author(s):  
W.G Beamer ◽  
C.J Rosen ◽  
R.T Bronson ◽  
W Gu ◽  
L.R Donahue ◽  
...  
Keyword(s):  
Bone Formation ◽  
Genetic Model ◽  
Spontaneous Fracture ◽  
Mouse Genetic Model ◽  
Mouse Genetic

scholarly journals Neural activation deficits in a mouse genetic model of NMDA receptor hypofunction in tests of social aggression and swim stress

2009 ◽  
Vol 1265 ◽  
pp. 186-195 ◽  
Author(s):  
Gary E. Duncan ◽  
Ken Inada ◽  
Joseph S. Farrington ◽  
Beverly H. Koller ◽  
Sheryl S. Moy
Keyword(s):  
Nmda Receptor ◽  
Genetic Model ◽  
Social Aggression ◽  
Neural Activation ◽  
Swim Stress ◽  
Mouse Genetic Model ◽  
Mouse Genetic

scholarly journals Evidence for vestibular regulation of autonomic functions in a mouse genetic model

2002 ◽  
Vol 99 (26) ◽  
pp. 17078-17082 ◽  
Author(s):  
D. M. Murakami ◽  
L. Erkman ◽  
O. Hermanson ◽  
M. G. Rosenfeld ◽  
C. A. Fuller
Keyword(s):  
Genetic Model ◽  
Autonomic Functions ◽  
Mouse Genetic Model ◽  
Mouse Genetic

Effects of ramelteon and triazolam in a mouse genetic model of early morning awakenings

2009 ◽  
Vol 1296 ◽  
pp. 46-55 ◽  
Author(s):  
Jonathan P. Wisor ◽  
Peng Jiang ◽  
Martin Striz ◽  
Bruce F. O'Hara
Keyword(s):  
Genetic Model ◽  
Early Morning ◽  
Mouse Genetic Model ◽  
Mouse Genetic

scholarly journals Maternal vitamin B12 in mice positively regulates bone, but not muscle mass and strength in post-weaning and mature offspring

2021 ◽  
Author(s):  
Parminder Singh ◽  
Svetalana Telnova ◽  
Bin Zhou ◽  
Abdalla D Mohamed ◽  
Vanessa De Mello ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Mass ◽  
Muscle Mass ◽  
Genetic Model ◽  
Single Injection ◽  
Structure And Function ◽  
Wild Type ◽  
And Function ◽  
Mouse Genetic Model ◽  
Mouse Genetic

Vitamin B12 deficiency has been shown to affect bone mass in rodents and negatively impact bone formation in humans. In this study using mouse models we define the effect of B12 supplementation in the wild-type mother and B12 deficiency in a mouse genetic model (Gif-/- mice) during gestation on the bone and muscle architecture, and mechanical properties in the offspring. Analysis of bones from 4 weeks-old offspring of the wild-type mother following vehicle or B12 supplementation during gestation (From embryonic day 0.5-20.5) showed an increase in bone mass caused by an isolated increase in bone formation in the B12 supplemented group compared to vehicle controls. Analysis of effect of B12 deficiency in the mother in a mouse genetic model (Gif-/- mice) on long bone architecture of the offspring showed a compromised cortical and trabecular bone mass, which was completely prevented by a single injection of B12 in the B12-deficient Gif-/- mothers.Biomechanical analysis of long bones of the offspring born from B12 supplemented wild-type mothers showed an increase in bone strength, and conversely offspring born from B12-deficient Gif-/- mothers revealed a compromised bone strength, which could be rescued by a single injection of B12 in the B12-deficient Gif-/- mother. Muscle structure and function analysis however revealed no significant effect on muscle mass, structure and grip strength of B12 deficiency or supplementation in Gif-/- mice compared to littermate controls. Together, these results demonstrate the beneficial effect of maternally-derived B12 in the regulation of bone structure and function in the offspring.

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