scholarly journals Effectiveness and side-effect profile of stimulant therapy as monotherapy and in combination in the central hypersomnias in clinical practice

2017 ◽  
Vol 27 (4) ◽  
pp. e12627 ◽  
Author(s):  
Chiraag Thakrar ◽  
Kishankumar Patel ◽  
Grainne D'ancona ◽  
Brian D. Kent ◽  
Alexander Nesbitt ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Side Effect ◽  
Side Effect Profile ◽  
Stimulant Therapy

Side-effect profile of sildenafil citrate (Viagra) in clinical practice

Urology ◽  
2000 ◽  
Vol 56 (3) ◽  
pp. 474-476 ◽  
Author(s):  
Sergio G Moreira ◽  
Robert E Brannigan ◽  
Aaron Spitz ◽  
Francisco J Orejuela ◽  
Larry I Lipshultz ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Side Effect ◽  
Sildenafil Citrate ◽  
Side Effect Profile

How do european psychiatry trainees prescribe when treating depression, and what influences decision-making? (Survey of the European Federation of Psychiatric Trainees Research Group)

2011 ◽  
Vol 26 (S2) ◽  
pp. 1248-1248
Author(s):  
S. Jauhar ◽  
S. Guloksuz ◽  
J.G. Marques ◽  
A. Nawka ◽  
C. Roventa ◽  
...  
Keyword(s):  
Decision Making ◽  
Clinical Practice ◽  
Research Group ◽  
Side Effect ◽  
Antidepressant Medication ◽  
Evidence Base ◽  
European Federation ◽  
Side Effect Profile ◽  
Factors Affecting ◽  
Factors Influencing

ObjectivesDespite recent recent evidence and subsequent guidelines that have suggested factors such as side-effect profile and cost should be taken into account when prescribing antidepressant medication, relatively little evidence exists on decision-making in clinical practice.Our Pan-European Research Group looked at clinical practice regarding antidepressants amongst Psychiatry trainees, treatments trainees would desire themselves, and factors influencing decision-making.MethodsA semi-structured survey was constructed from recent literature, was piloted, and a homogenous sample size of at least 50 agreed upon from each country, with 50% the minimum response rate. It was distributed via web-link, questioning preference of antidepressant for patients, and factors influencing choice. Trainees were asked for their preference should they develop a moderate to severe depressive episode, and require medication.ResultsTreatment choices are summarised in Table 1. 79% of trainees would prescribe similar antidepressants for themselves as for patients.Factors influencing decision-making mapped onto three main domains: cost, efficacy and side-effect profile (5% other reasons). 86% (n = 548) of those who responded felt efficacy most important, 38% (n = 237) felt side-effect profile most important and 6% (n = 33) considered cost of most importance.ConclusionsSome differences exist in choice of antidepressant for European trainees and their patients, and factors affecting choice conflict with evidence base and guideline suggestions.

Valproic Acid:

1999 ◽  
Vol 16 (2) ◽  
pp. 130-136 ◽  
Author(s):  
Sayonara Beatriz Ranciaro Fagundes
Keyword(s):  
Health Care ◽  
Valproic Acid ◽  
Antiepileptic Drug ◽  
Detailed Analysis ◽  
Side Effect ◽  
Side Effect Profile ◽  
Care Givers

Clinical pharmacologists, neurologists, and all health care givers must consider the efficacy, safety, and side effect profile of a given antiepileptic drug when determining which drug is best for a given patient.The purpose of this study was to investigate valproic acid with a detailed analysis of the different reports.

Long-term efficacy and safety of imiquimod 5% and fluorouracil 1% creams in medical monotherapy of complex eyelid basal cell carcinomas

2021 ◽  
pp. 112067212110356
Author(s):  
Manpreet Singh ◽  
Aditi Mehta Grewal ◽  
Himanshi Singh ◽  
Manjula Sharma ◽  
Manpreet Kaur ◽  
...  
Keyword(s):  
Basal Cell ◽  
Side Effect ◽  
The Elderly ◽  
Fixed Dose ◽  
Side Effect Profile ◽  
Efficacy And Safety ◽  
Term Efficacy ◽  
Basal Cell Carcinomas ◽  
Double Blinded

Purpose: To study the long-term efficacy and safety of local application of imiquimod 5% and fluorouracil 1% creams in complex eyelid basal cell carcinomas (BCCs). Methods: A retrospective, non-comparative study in biopsy-proven, complex (involving canthi or >50% of eyelid length) eyelid BCC patients who were medically unfit for surgical procedures. All patients were medically treated with either of the creams using fixed-dose regimens for a minimum of 3 months. All received oral vitamin C 500 mg QID for 3 months as an adjunct for collagen healing. A minimum of “post-treatment” follow-up of 12 months was observed. Results: Of total 30 patients, imiquimod 5% and fluorouracil 1% were used in 16 and 14 patients, respectively. The mean age of our patients was 70.5 years. The co-morbidities included – severe coronary artery disease using blood-thinners ( n = 19), poorly controlled diabetes ( n = 12), poorly controlled hypertension ( n = 6), on nebulization ( n = 3), and tuberculosis with pulmonary fibrosis ( n = 2). Complete clinical tumor resolution was noted in 10 and 8 patients over 12 and 16.5 weeks, respectively, in imiquimod and fluorouracil groups. Periocular skin erythema, chemical conjunctivitis, and skin depigmentation were seen in all the patients of imiquimod group. On the other hand, the local side-effect profile in fluorouracil patients was limited. Conclusion: The medical treatment of complex eyelid BCC is a useful alternative to surgery in the elderly with significant co-morbidities. It provides a promising long-term relief with a tolerable side-effect profile. A prospective, randomized, double-blinded trial would provide stronger evidence for the efficacy of these drugs.

Design of Novel Photosensitizers and Controlled Singlet Oxygen Generation for Photodynamic Therapy

2021 ◽  
Author(s):  
Esra Tanrıverdi Eçik ◽  
Onur BULUT ◽  
Hasan Hüseyin Kazan ◽  
Elif Şenkuytu ◽  
Bunyemin Cosut
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Treatment ◽  
Singlet Oxygen ◽  
Side Effect ◽  
Side Effect Profile ◽  
High Ability ◽  
Lower Side ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Promising Strategy

Photodynamic therapy (PDT) is a promising strategy in cancer treatment with its relatively lower side effect profile. Undoubtedly, the key component of PDT is the photosensitizers with a high ability...

scholarly journals Efficacy and Side Effect Profile of Different Formulations of Metformin: A Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Jane L. Tarry-Adkins ◽  
Imogen D. Grant ◽  
Susan E. Ozanne ◽  
Rebecca M. Reynolds ◽  
Catherine E. Aiken
Keyword(s):  
Systematic Review ◽  
Side Effect ◽  
Meta Analysis ◽  
Side Effect Profile

scholarly journals Simultaneous targeting of multiple opioid receptors: a strategy to improve side-effect profile

2009 ◽  
Vol 103 (1) ◽  
pp. 38-49 ◽  
Author(s):  
N. Dietis ◽  
R. Guerrini ◽  
G. Calo ◽  
S. Salvadori ◽  
D.J. Rowbotham ◽  
...  
Keyword(s):  
Opioid Receptors ◽  
Side Effect ◽  
Side Effect Profile

MEL-N16: A Series of Novel Endomorphin Analogs with Good Analgesic Activity and a Favorable Side Effect Profile

2017 ◽  
Vol 8 (10) ◽  
pp. 2180-2193 ◽  
Author(s):  
Xin Liu ◽  
Long Zhao ◽  
Yuan Wang ◽  
Jingjing Zhou ◽  
Dan Wang ◽  
...  
Keyword(s):  
Analgesic Activity ◽  
Side Effect ◽  
Side Effect Profile ◽  
Favorable Side Effect Profile
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