scholarly journals Association between left atrial enlargement and obstructive sleep apnea in a general population of 71-year-old men

2017 ◽  
Vol 27 (2) ◽  
pp. 254-260 ◽  
Author(s):  
Henrik Holtstrand Hjälm ◽  
Michael Fu ◽  
Per-Olof Hansson ◽  
You Zhong ◽  
Kenneth Caidahl ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
General Population ◽  
Left Atrial ◽  
Left Atrial Enlargement ◽  
Obstructive Sleep ◽  
Atrial Enlargement ◽  
Old Men

scholarly journals Risk of Left Atrial Enlargement in Obese Patients With Obesity-Induced Hypoventilation Syndrome vs Obstructive Sleep Apnea

2018 ◽  
Vol 18 (2) ◽  
pp. 136-140 ◽  
Author(s):  
Yasser Al-Khadra ◽  
Fahed Darmoch ◽  
Mohammad Alkhatib ◽  
Motaz Baibars ◽  
M. Chadi Alraies
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Left Atrial ◽  
Obese Patients ◽  
Left Atrial Enlargement ◽  
Obstructive Sleep ◽  
Atrial Enlargement ◽  
Hypoventilation Syndrome

scholarly journals Obstructive Sleep Apnea as a Risk Factor for Cerebral White Matter Change in a Middle-Aged and Older General Population

SLEEP ◽  
2013 ◽  
Vol 36 (5) ◽  
pp. 709-715 ◽  
Author(s):  
Hyun Kim ◽  
Chang-Ho Yun ◽  
Robert Joseph Thomas ◽  
Seung Hoon Lee ◽  
Hyung Suk Seo ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Risk Factor ◽  
Sleep Apnea ◽  
White Matter ◽  
General Population ◽  
White Matter Change ◽  
Cerebral White Matter ◽  
Middle Aged ◽  
Obstructive Sleep

Awareness and knowledge of obstructive sleep apnea among the general population

2017 ◽  
Vol 36 ◽  
pp. 10-17 ◽  
Author(s):  
Ching-Hui Sia ◽  
Yueheng Hong ◽  
Linda W.L. Tan ◽  
Rob M. van Dam ◽  
Chi-Hang Lee ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
General Population ◽  
Obstructive Sleep

scholarly journals Excessive Daytime Sleepiness in Depression and Obstructive Sleep Apnea: More Than Just an Overlapping Symptom

2021 ◽  
Vol 12 ◽  
Author(s):  
Danwei Zhang ◽  
Zhen Zhang ◽  
Huihua Li ◽  
Kaimo Ding
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
General Population ◽  
Excessive Daytime Sleepiness ◽  
Daytime Sleepiness ◽  
Health Concern ◽  
Therapeutic Effects ◽  
Obstructive Sleep ◽  
Significant Public Health ◽  
The Relationship

Excessive daytime sleepiness (EDS) is a significant public health concern, with obstructive sleep apnea (OSA) being a common cause, and a particular relationship exists with the severity of depression. A literature search on OSA, depression, and EDS was performed in PubMed. The chosen evidence was limited to human studies. Available evidence was systematically reviewed to ascertain the association of EDS with depression and OSA according to the general population and some specific population subgroups. In addition, effectiveness of continuous positive airway pressure (CPAP) was analyzed as a standard therapy for improving EDS and depression in patients with OSA. In the general population, patients with OSA, and some other subpopulations, the review contributed to: (1) delineating the prevalence of EDS; (2) substantiating the relationship of EDS and depression; (3) presenting the relationship between EDS and OSA; and (4) revealing that the duration of CPAP is crucial for its therapeutic effects in improving EDS and depressive symptoms in patients with OSA.

scholarly journals GJA1 Expression and Left Atrial Remodeling in the Incidence of Atrial Fibrillation in Patients with Obstructive Sleep Apnea Syndrome

Biomedicines ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1463
Author(s):  
Yung-Lung Chen ◽  
Yung-Che Chen ◽  
Ya-Ting Chang ◽  
Hui-Ting Wang ◽  
Wen-Hao Liu ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Crucial Role ◽  
Left Atrial ◽  
Sleep Apnea Syndrome ◽  
Left Ventricular Ejection ◽  
Obstructive Sleep ◽  
Apnea Syndrome

Obstructive sleep apnea syndrome (OSAS) is an important risk factor for atrial fibrillation (AF). GJA1 gene encoding connexin43, a major protein in cardiac gap junctions, plays a crucial role in the synchronized contraction of the heart and in cardiac arrhythmia. However, little is known regarding the role of GJA1 expression in the incidence of AF in patients with OSAS. All prospectively enrolled OSAS patients underwent polysomnography, electrocardiography, a 24-hour Holter test, and echocardiography. Moderate-to-severe OSAS was defined as an apnea-hypopnea index (AHI) ≥ 15. Exosomes were purified from the plasma of all OSAS patients and incubated in HL-1 cells to investigate the effect of exosomes from patients with and without AF on GJA1 expression. A total of 129 patients were recruited for this study; 26 were excluded due to an AHI < 15. Of the 103 enrolled patients, 21 had AF, and 82 did not. Multivariate analysis showed diabetes mellitus, lower sleep efficiency, lower left ventricular ejection fraction, and larger left atrial (LA) size were independent predictors of AF occurrence in OSAS patients. The area under the receiver operating characteristic curve for LA with a size ≥ 38.5 mm for predicting AF occurrence in OSAS patients was 0.795 (95% confidence interval [0.666, 0.925]); p < 0.001). GJA1 expression in HL-1 cells incubated with exosomes from OSAS patients with AF was lower than that with exosomes from patients without AF after controlling for age and sex and was negatively correlated with the AHI and oxygen desaturation index (ODI), especially during the non-rapid eye movement period (NREM) of OSAS patients with AF (all p < 0.05). LA size was an independent predictor of AF occurrence in OSAS patients. The AHI and ODI in the NREM period of OSAS patients with AF were negatively correlated with GJA1 expression in HL-1 cells, which offers a hint that GJA1 may play a crucial role in the development of AF in patients with OSAS.

scholarly journals Tormented Sunrises

2019 ◽  
pp. 418-434
Author(s):  
Maha Alattar
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
General Population ◽  
Sleep Disorders ◽  
Headache Disorders ◽  
Distinct Subset ◽  
Obstructive Sleep ◽  
High Prevalence ◽  
The Relationship

This chapter covers the relationship between sleep-related headaches and sleep disorders such as obstructive sleep apnea (OSA). Sleep apnea headache (SAH), a type of sleep-related headache that is classified in the International Classification of Headache Disorders, is a distinct subset of headache that is caused by OSA and occurs distinctly on awakening. Once recognized, treatment of OSA is associated with significant improvement in, and often resolution of, SAH. Given the high prevalence of headaches in the general population, sleep disorders must be considered in the evaluation of patients with headaches. A comprehensive sleep evaluation should be an integral part of the assessment of headache disorders. Sleep apnea headache and other types of headaches associated with sleep are reviewed in this chapter.

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