scholarly journals Sleep restriction in rats leads to changes in operant behaviour indicative of reduced prefrontal cortex function

2016 ◽  
Vol 26 (1) ◽  
pp. 5-13 ◽  
Author(s):  
Jeanine Kamphuis ◽  
Swetlana Baichel ◽  
Marike Lancel ◽  
Sietse F. de Boer ◽  
Jaap M. Koolhaas ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Operant Behaviour ◽  
Sleep Restriction

scholarly journals Effects of Chronic REM Sleep Restriction on D1Receptor and Related Signal Pathways in Rat Prefrontal Cortex

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Yan Han ◽  
Xiaosa Wen ◽  
Fei Rong ◽  
Xinmin Chen ◽  
Ruying Ouyang ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Rem Sleep ◽  
Molecular Mechanisms ◽  
Sleep Restriction ◽  
Signal Pathways ◽  
Neural Function ◽  
Multiple Platform ◽  
Pka Pathway ◽  
Chronic Sleep ◽  
Neural Dysfunction

The prefrontal cortex (PFC) mediates cognitive function that is sensitive to disruption by sleep loss, and molecular mechanisms regulating neural dysfunction induced by chronic sleep restriction (CSR), particularly in the PFC, have yet to be completely understood. The aim of the present study was to investigate the effect of chronic REM sleep restriction (REM-CSR) on the D1receptor (D1R) and key molecules in D1R’ signal pathways in PFC. We employed the modified multiple platform method to create the REM-CSR rat model. The ultrastructure of PFC was observed by electron microscopy. HPLC was performed to measure the DA level in PFC. The expressions of genes and proteins of related molecules were assayed by real-time PCR and Western blot, respectively. The general state and morphology of PFC in rats were changed by CSR, and DA level and the expression of D1R in PFC were markedly decreased (P<0.01,P<0.05); the expression of phosphor-PKAcαwas significantly lowered in CSR rats (P<0.05). The present results suggested that the alteration of neuropathology and D1R expression in PFC may be associated with CSR induced cognitive dysfunction, and the PKA pathway of D1R may play an important role in the impairment of advanced neural function.

scholarly journals Sleep restriction caused impaired emotional regulation without detectable brain activation changes—a functional magnetic resonance imaging study

2019 ◽  
Vol 6 (3) ◽  
pp. 181704 ◽  
Author(s):  
Sandra Tamm ◽  
Gustav Nilsonne ◽  
Johanna Schwarz ◽  
Armita Golkar ◽  
Göran Kecklund ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Emotional Regulation ◽  
Emotional Processing ◽  
Brain Activity ◽  
Cognitive Reappraisal ◽  
Imaging Study ◽  
Sleep Restriction ◽  
Dorsolateral Prefrontal ◽  
Normal Sleep ◽  
Increased Activity

Sleep restriction has been proposed to cause impaired emotional processing and emotional regulation by inhibiting top-down control from prefrontal cortex to amygdala. Intentional emotional regulation after sleep restriction has, however, never been studied using brain imaging. We aimed here to investigate the effect of partial sleep restriction on emotional regulation through cognitive reappraisal. Forty-seven young (age 20–30) and 33 older (age 65–75) participants (38/23 with complete data and successful sleep intervention) performed a cognitive reappraisal task during fMRI after a night of normal sleep and after restricted sleep (3 h). Emotional downregulation was associated with significantly increased activity in the dorsolateral prefrontal cortex ( p FWE < 0.05) and lateral orbital cortex ( p FWE < 0.05) in young, but not in older subjects. Sleep restriction was associated with a decrease in self-reported regulation success to negative stimuli ( p < 0.01) and a trend towards perceiving all stimuli as less negative ( p = 0.07) in young participants. No effects of sleep restriction on brain activity nor connectivity were found in either age group. In conclusion, our data do not support the idea of a prefrontal-amygdala disconnect after sleep restriction, and neural mechanisms underlying behavioural effects on emotional regulation after insufficient sleep require further investigation.

scholarly journals Sleep restriction caused impaired emotional regulation without detectable brain activation changes – a functional magnetic resonance imaging study

2018 ◽  
Author(s):  
Sandra Tamm ◽  
Gustav Nilsonne ◽  
Johanna Schwarz ◽  
Armita Golkar ◽  
Göran Kecklund ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Emotional Regulation ◽  
Emotional Processing ◽  
Brain Activity ◽  
Cognitive Reappraisal ◽  
Imaging Study ◽  
Sleep Restriction ◽  
Dorsolateral Prefrontal ◽  
Normal Sleep ◽  
Increased Activity

SummarySleep restriction has been proposed to cause impaired emotional processing and emotional regulation by inhibiting top-down control from prefrontal cortex to amygdala. Intentional emotional regulation after sleep restriction has however never been studied using brain imaging. We here aimed to investigate the effect of sleep restriction on emotional regulation through cognitive reappraisal. Forty-seven young (age 20-30) and 33 older (age 65-75) participants (38/23 with complete data and successful sleep intervention) performed a cognitive reappraisal task during fMRI after a night of normal sleep and after restricted sleep (3h). Emotional downregulation was associated with significantly increased activity in dorsolateral prefrontal cortex (pFWE < 0.05) and lateral orbital cortex (pFWE < 0.05) in young, but not in older subjects. Sleep restriction was associated with a decrease in self-reported regulation success to negative stimuli (p < 0.01) and a trend towards perceiving all stimuli as less negative (p = 0.07), in young participants. No effects of sleep restriction on brain activity nor connectivity were found in either age group. In conclusion, our data do not support the idea of a prefrontal-amygdala disconnect after sleep restriction, and neural mechanisms underlying behavioural effects on emotional regulation after insufficient sleep require further investigation.

scholarly journals Neuropeptide S overcomes short term memory deficit induced by sleep restriction by increasing prefrontal cortex activity

2017 ◽  
Vol 27 (12) ◽  
pp. 1308-1318 ◽  
Author(s):  
Julien Thomasson ◽  
Frédéric Canini ◽  
Betty Poly-Thomasson ◽  
Marion Trousselard ◽  
Sylvie Granon ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Short Term Memory ◽  
Memory Deficit ◽  
Sleep Restriction ◽  
Neuropeptide S ◽  
Short Term ◽  
Term Memory

Author response for "Remodeling of projections from ventral hippocampus to prefrontal cortex in Alzheimer's mice"

2020 ◽  
Author(s):  
Feng Xu ◽  
Munenori Ono ◽  
Tetsufumi Ito ◽  
Osamu Uchiumi ◽  
Furong Wang ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Ventral Hippocampus ◽  
Author Response

Malfunctional Reorganization in the Developing Limbo-Prefrontal System in Animals: Implications for Human Psychoses?

2001 ◽  
Vol 12 (1) ◽  
pp. 8-14
Author(s):  
Gertraud Teuchert-Noodt ◽  
Ralf R. Dawirs
Keyword(s):  
Prefrontal Cortex ◽  
Mental Disorders ◽  
Dentate Gyrus ◽  
Cognitive Functions ◽  
Experimental Approach ◽  
Regulatory Mechanisms ◽  
Hippocampal Dentate Gyrus ◽  
Non Invasive ◽  
Invasive Method ◽  
Activity Dependent

Abstract: Neuroplasticity research in connection with mental disorders has recently bridged the gap between basic neurobiology and applied neuropsychology. A non-invasive method in the gerbil (Meriones unguiculus) - the restricted versus enriched breading and the systemically applied single methamphetamine dose - offers an experimental approach to investigate psychoses. Acts of intervening affirm an activity dependent malfunctional reorganization in the prefrontal cortex and in the hippocampal dentate gyrus and reveal the dopamine position as being critical for the disruption of interactions between the areas concerned. From the extent of plasticity effects the probability and risk of psycho-cognitive development may be derived. Advance may be expected from insights into regulatory mechanisms of neurogenesis in the hippocampal dentate gyrus which is obviously to meet the necessary requirements to promote psycho-cognitive functions/malfunctions via the limbo-prefrontal circuit.

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