A Toll‐Like Receptor 1/2 Agonist Augments Contractility in Rat Corpus Cavernosum

2015 ◽  
Vol 12 (8) ◽  
pp. 1722-1731 ◽  
Author(s):  
Inger Stallmann‐Jorgensen ◽  
Safia Ogbi ◽  
Theodora Szasz ◽  
R. Clinton Webb
Keyword(s):  
Corpus Cavernosum ◽  
Toll Like Receptor

Macrophage-Specific Toll Like Receptor 9 (TLR9) Causes Corpus Cavernosum Dysfunction in Mice Fed a High Fat Diet

2021 ◽  
Author(s):  
Fernanda Priviero ◽  
Fabiano Calmasini ◽  
Vanessa Dela Justina ◽  
Camilla F. Wenceslau ◽  
Cameron G. McCarthy ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Corpus Cavernosum ◽  
Toll Like Receptor ◽  
High Fat

scholarly journals Toll‐like receptor 2 activation increases contractile responses in rat corpus cavernosum (1158.6)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Inger Stallmann‐Jorgensen ◽  
Camilla Wenceslau ◽  
Safia Ogbi ◽  
R. Clinton Webb
Keyword(s):  
Corpus Cavernosum ◽  
Toll Like Receptor ◽  
Contractile Responses ◽  
Toll Like Receptor 2

scholarly journals Functional Impairment in the Corpus Cavernosum Related to a High Fat Diet is Prevented in Toll‐Like Receptor 9 Mutant Mice

2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
Fernanda Priviero ◽  
Fabiano Beraldi Calmasini ◽  
Cameron McCarthy ◽  
Camilla Ferreira Wenceslau ◽  
Edson Antunes ◽  
...  
Keyword(s):  
Functional Impairment ◽  
High Fat Diet ◽  
Corpus Cavernosum ◽  
Mutant Mice ◽  
Toll Like Receptor ◽  
High Fat

Abstract 647: Toll-like Receptor 4 (TLR4) Activation Impairs the Nitrergic Relaxation Response in Rat Corpus Cavernosum

Hypertension ◽  
2012 ◽  
Vol 60 (suppl_1) ◽  
Author(s):  
Inger S Stallmann-Jorgensen ◽  
Jason E Davis ◽  
Maria Alicia Carrillo-Sepulveda ◽  
R. Clinton Webb
Keyword(s):  
Blood Pressure ◽  
Vascular Reactivity ◽  
Corpus Cavernosum ◽  
Receptor Activation ◽  
Ros Generation ◽  
Toll Like Receptor ◽  
Response Curves ◽  
Toll Like Receptor 4 ◽  
Disease Etiology ◽  
Tlr4 Activation

Cardiovascular disease etiology of hypertension and atherosclerosis has been shown to involve pattern-recognition receptor activation, including toll-like receptor 4 (TLR4). Indeed, our lab showed that TLR4 activation was implicated in blood pressure regulation, and its blockade lowered blood pressure in spontaneously hypertensive rats. However, whether TLR4 activation plays a role in erectile dysfunction is not known. Therefore, we hypothesized that TLR4 activation using its ligand, lipopolysaccharide (LPS), would increase reactive oxygen species (ROS) and impair corpus cavernosum (CC) relaxation. To test our hypothesis, rat CC smooth muscle cells were incubated for 15 min with LPS (100 ng/mL) and ROS detected with a fluorescent probe. Treatment with LPS resulted in an increase in ROS, compared to baseline (Fig.1). To investigate vascular reactivity to TLR4 activation, we performed myograph studies on CC isolated from 13-15 week old Sprague-Dawley rats, then incubated 3 hours in DMEM with LPS (+LPS) or vehicle (VEH). Concentration response curves to phenyleprine (PE, 10 -9 -10 -4 M) and to non-adrenergic, non-cholinergic (NANC) stimulation were used to investigate CC reactivity. Contractility to PE did not differ between groups, but +LPS-induced relaxation responses decreased significantly to 20-volt electrical field stimulation compared to VEH (8Hz: 16.3 vs 24.9, p< 0.01 and 16 Hz: 21.2 vs 35.1, p< 0.001). In conclusion, treatment with the TLR4 agonist, LPS, decreased NANC relaxation in the CC. Increased ROS generation may result in scavenging and reducing availability of nitric oxide that could impair relaxation in the CC.

Toll-like receptor 2 signaling is important for fas ligand on NKT cells, may contribute to liver injury induced by Salmonella infection

2001 ◽  
Vol 120 (5) ◽  
pp. A357-A357
Author(s):  
H SHIMIZU ◽  
Y FUKUDA ◽  
I NAKANO ◽  
Y KATANO ◽  
K NAGANO ◽  
...  
Keyword(s):  
Liver Injury ◽  
Fas Ligand ◽  
Nkt Cells ◽  
Toll Like Receptor ◽  
Salmonella Infection ◽  
Toll Like Receptor 2

1004: In-Vivo Transfection of the Rat Corpus Cavernosum Using a Non-Viral, Linear Polyethylenimine Gene Delivery System: A Novel Application

2006 ◽  
Vol 175 (4S) ◽  
pp. 323-324 ◽  
Author(s):  
Joseph Dall'era ◽  
Sweaty Koul ◽  
Jesse Mills ◽  
Jeremy Myers ◽  
Randall B. Meacham ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Corpus Cavernosum ◽  
Gene Delivery System ◽  
System A ◽  
In Vivo Transfection ◽  
Linear Polyethylenimine

1607: Neuronally Released 5-Hydroxytryptamine Induced Contractions of the Human Corpus Cavernosum

2004 ◽  
Vol 171 (4S) ◽  
pp. 424-424
Author(s):  
David H. Lau ◽  
Cecil S. Thompson ◽  
Dimitri P. Mikhailidis ◽  
Robert J. Morgan
Keyword(s):  
Corpus Cavernosum

1429: Upregulation of Rho-Kinase in a Human Corpus Cavernosum Smooth Muscle Cell Line in Response to Hypoxia

2004 ◽  
Vol 171 (4S) ◽  
pp. 376-377
Author(s):  
Yongmu Zheng ◽  
Shaohua Chang ◽  
Alan J. Wein ◽  
Samuel Chacko ◽  
Michael E. DiSanto
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Cell Line ◽  
Muscle Cell ◽  
Corpus Cavernosum ◽  
Rho Kinase ◽  
Muscle Cell Line

660 Deficiency of Toll-like receptor 4 leads to cardioprotection against doxorubicin-induced cardiomyopathy

2007 ◽  
Vol 6 (1) ◽  
pp. 142-143
Author(s):  
A RIAD ◽  
S BIEN ◽  
M GRATZ ◽  
S BERESWILL ◽  
H SCHULTHEISS ◽  
...  
Keyword(s):  
Toll Like Receptor ◽  
Toll Like Receptor 4
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