Role of the Different Sexuality Domains on the Sexual Function of Women with Premature Ovarian Failure

2015 ◽  
Vol 12 (3) ◽  
pp. 685-689 ◽  
Author(s):  
Cristina Laguna Benetti‐Pinto ◽  
Patrícia Magda Soares ◽  
Helena Patrícia Donovan Giraldo ◽  
Daniela Angerame Yela
Keyword(s):  
Sexual Function ◽  
Premature Ovarian Failure ◽  
Ovarian Failure

scholarly journals Cytogenetics of Premature Ovarian Failure: An Investigation on 269 Affected Women

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Simona Baronchelli ◽  
Donatella Conconi ◽  
Elena Panzeri ◽  
Angela Bentivegna ◽  
Serena Redaelli ◽  
...  
Keyword(s):  
X Chromosome ◽  
Premature Ovarian Failure ◽  
Ovarian Function ◽  
Sex Chromosome ◽  
Chromosomal Abnormalities ◽  
Population Group ◽  
Ovarian Failure ◽  
Chromosome Mosaicism ◽  
Low Level

The importance of X chromosome in the aetiology of premature ovarian failure (POF) is well-known but in many cases POF still remains idiopathic. Chromosome aneuploidy increase is a physiological phenomenon related to aging, but the role of low-level sex chromosome mosaicism in ovarian function is still undiscovered. Standard cytogenetic analysis was carried out in a total of 269 patients affected by POF: 27 chromosomal abnormalities were identified, including X chromosome and autosomal structural and numerical abnormalities. In 47 patients with 46,XX karyotype we performed interphase FISH using X alpha-satellite probe in order to identify X chromosome mosaicism rate. Aneuploidy rate in the patient group was significantly higher than the general population group. These findings underline the importance of X chromosome in the aetiology of POF and highlight the potential role of low-level sex chromosome mosaicism in ovarian aging that may lead to a premature onset of menopause.

025. Prolactin signaling through the short form of its cognate receptor causes severe ovarian defect

2005 ◽  
Vol 17 (9) ◽  
pp. 68
Author(s):  
G. Gibori ◽  
J. Halpern ◽  
C. Stocco ◽  
P. Kelly ◽  
N. Binart
Keyword(s):  
Premature Ovarian Failure ◽  
Short Form ◽  
Ovarian Failure ◽  
Specific Gene ◽  
Steroidogenic Enzyme ◽  
Prolactin Signaling ◽  
Long Form ◽  
Membrane Bound ◽  
First Time

Extensive investigations from our laboratory have clarified the action and interaction of estradiol (E) and prolactin (PRL) on corpus luteum (CL) function. Our research has led us to discover and isolate a CL specific gene that encodes a protein we named PRAP, that associates with the intracellular domain of the short form (PRLRS) but not the long form (PRLRL) and whose expression is tightly regulated by E. Our laboratory and others have established that this protein, expressed in CL of every species investigated, is a novel 17 beta hydroxysteroid dehydrogenase (17bHSD-7) whose function is to catalyze the transformation of estrone to E. Our results with cells expressing only PRLRS revealed that PRL acting through PRLRS leads to phosphorylation of PRAP/17bHSD-7 (PRAP/17b) by JAK2 establishing for the first time that a steroidogenic enzyme can be phosphorylated through its association with a membrane bound protein. The association of PRAP/17b with the PRLRS and its phosphorylation leads to its stabilization. To further investigate the role of PRL signaling through PRLRS, we used PRLR(–/–) mice expressing the PRLRS as a transgene. The results obtained were totally unexpected and of great interest. The follicles of the ovaries, expressing PRLRS only, underwent premature development followed by severe granulosa and oocyte death leaving holes surrounding collapsed zona pellucida and premature ovarian failure. The observations that: (1) the expression of PRLRS in the ovaries of PRL null mice leads to inhibition in Foxo3a and of GALT, two proteins whose deletion/mutation causes similar premature ovarian failure; and (2) that GALT promoter activity is stimulated by Foxo3a transcription factor led us to hypothesize that PRL acting through PRLRS prevents the expression of Foxo3a, which normally stimulates GALT transcriptional activity. Absence of Foxo3a then leads to inhibition of GALT and increases in galactose and its metabolites, causing galactose toxicity and granulosa as well as oocyte cell death.

scholarly journals Investigating the role of X chromosome breakpoints in premature ovarian failure

2012 ◽  
Vol 5 (1) ◽  
pp. 32 ◽  
Author(s):  
Simona Baronchelli ◽  
Nicoletta Villa ◽  
Serena Redaelli ◽  
Sara Lissoni ◽  
Fabiana Saccheri ◽  
...  
Keyword(s):  
X Chromosome ◽  
Premature Ovarian Failure ◽  
Ovarian Failure

Role of SDF-1/CXCR4 and cytokines in the development of ovary injury in chemotherapy drug induced premature ovarian failure mice

Life Sciences ◽  
2017 ◽  
Vol 179 ◽  
pp. 103-109 ◽  
Author(s):  
Qianqian Luo ◽  
Na Yin ◽  
Lianshuang Zhang ◽  
Wendan Yuan ◽  
Wei Zhao ◽  
...  
Keyword(s):  
Premature Ovarian Failure ◽  
Ovarian Failure ◽  
Drug Induced ◽  
Chemotherapy Drug

M083 ROLE OF BMP-15 GENE IN THE PATHOGENESIS OF PREMATURE OVARIAN FAILURE (POF)

2012 ◽  
Vol 119 ◽  
pp. S558-S559
Author(s):  
I. Pagano ◽  
M. Stracquadanio ◽  
S. Di Leo ◽  
C. Formuso ◽  
L. Coco ◽  
...  
Keyword(s):  
Premature Ovarian Failure ◽  
Ovarian Failure

The Role of Premature Ovarian Failure Awareness in Female Sexual Functions and Distress

2016 ◽  
Vol 43 (4) ◽  
pp. 354-360 ◽  
Author(s):  
Serdar Aydin ◽  
Seda Ateş ◽  
Çağri Arioğlu Aydin ◽  
Gonca Batmaz
Keyword(s):  
Premature Ovarian Failure ◽  
Ovarian Failure
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