Male Sexual Function Can Be Maintained Without Aromatization: Randomized Placebo‐Controlled Trial of Dihydrotestosterone (DHT) in Healthy, Older Men for 24 Months

2014 ◽  
Vol 11 (10) ◽  
pp. 2562-2570 ◽  
Author(s):  
Gideon A. Sartorius ◽  
Lam P. Ly ◽  
David J. Handelsman
2019 ◽  
Vol 7 (10) ◽  
pp. 98 ◽  
Author(s):  
Chung

Sexual function among older men is often thought to decrease as part of normal ageing biology despite the fact that sexuality remains an important issue in the elderly. Sexual dysfunction in the aged male is likely multifactorial in nature, with the development and/or progression of medical comorbidities often resulting in decline in male sexual function and poor treatment response. At present, sexual dysfunction in the ageing male is poorly investigated and understood, and current treatment strategies aim at improving sexual desire and erectile function with limited data on ejaculatory and orgasmic dysfunctions. In addition, men are often reticent to seek help for health concerns including sexual dysfunction. The following article provides a narrative review of strategies to address various aspects of sexual dysfunction in the ageing male. Clinicians need to be educated to be sensitive when discussing sexuality issues among older men and to present practical solutions that take into account individual and cultural differences.


2016 ◽  
Vol 101 (8) ◽  
pp. 3096-3104 ◽  
Author(s):  
Glenn R. Cunningham ◽  
Alisa J. Stephens-Shields ◽  
Raymond C. Rosen ◽  
Christina Wang ◽  
Shalender Bhasin ◽  
...  

Context: The Testosterone Trials are a coordinated set of seven trials to determine the efficacy of T in symptomatic men ≥65 years old with unequivocally low T levels. Initial results of the Sexual Function Trial showed that T improved sexual activity, sexual desire, and erectile function. Objective: To assess the responsiveness of specific sexual activities to T treatment; to relate hormone changes to changes in sexual function; and to determine predictive baseline characteristics and T threshold for sexual outcomes. Design: A placebo-controlled trial. Setting: Twelve academic medical centers in the United States. Participants: A total of 470 men ≥65 years of age with low libido, average T <275 ng/dL, and a partner willing to have sexual intercourse at least twice a month. Methods: Men were assigned to take T gel or placebo for 1 year. Sexual function was assessed by three questionnaires every 3 months: the Psychosexual Daily Questionnaire, the Derogatis Interview for Sexual Function, and the International Index of Erectile Function. Results: Compared with placebo, T administration significantly improved 10 of 12 measures of sexual activity. Incremental increases in total and free T and estradiol levels were associated with improvements in sexual activity and desire, but not erectile function. No threshold T level was observed for any outcome, and none of the 27 baseline characteristics predicted responsiveness to T. Conclusions: In older men with low libido and low T levels, improvements in sexual desire and activity in response to T treatment were related to the magnitude of increases in T and estradiol levels, but there was no clear evidence of a threshold effect.


2017 ◽  
Vol 14 (2) ◽  
pp. e69
Author(s):  
H. Abdel Hafez ◽  
A.A. Abdel-Motaleb ◽  
H.D. Gaber ◽  
G.S.T. Al-Attar

2011 ◽  
Vol 8 (10) ◽  
pp. 2944-2953 ◽  
Author(s):  
Alfredo L. Milani ◽  
Mariella I.J. Withagen ◽  
Hok S. The ◽  
Ileana Nedelcu‐van der Wijk ◽  
Mark E. Vierhout

Maturitas ◽  
2021 ◽  
Vol 152 ◽  
pp. 70-71
Author(s):  
Parvin Abedi ◽  
Ilnaz Zohrabi ◽  
Somayeh Ansari ◽  
Elham Maraghi ◽  
Nader Shakiba Maram ◽  
...  

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