Neogene and Quaternary climate changes shaped the lineage differentiation and demographic history of Fokienia hodginsii (Cupressaceae s.l.), a Tertiary relict in East Asia

Author(s):  
Qian‐Yi Yin ◽  
Qiang Fan ◽  
Pan Li ◽  
DoVan Truong ◽  
Wan‐Yi Zhao ◽  
...  
2014 ◽  
Vol 122 (6) ◽  
pp. 687-703 ◽  
Author(s):  
Lucile Bonneau ◽  
Stéphan J. Jorry ◽  
Samuel Toucanne ◽  
Ricardo Silva Jacinto ◽  
Laurent Emmanuel

2020 ◽  
Vol 10 (3) ◽  
pp. 1454-1468
Author(s):  
Tao Chen ◽  
Juan Chen ◽  
Ling Tang ◽  
Xiaoning Chen ◽  
Jun Yan ◽  
...  

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Dingwen Lin ◽  
Junning Wang ◽  
Zhezhe Cui ◽  
Jing Ou ◽  
Liwen Huang ◽  
...  

Abstract Background Tuberculosis (TB) is caused by a bacterium called Mycobacterium tuberculosis (Mtb). China is the third in top 8 high TB burden countries and Guangxi is one of the high incidence areas in South China. Determine bacterial factors that affected TB incidence rate is a step toward Ending the TB epidemic. Results Genomes of M. tuberculosis cultures from a relatively high and low incidence region in Guangxi have been sequenced. 347 of 358(96.9%) were identified as M. tuberculosis. All the strains belong to Lineage 2 and Lineage 4, except for one in Lineage 1. We found that the genetic structure of the M. tuberculosis population in each county varies enormously. Low incidence rate regions have a lower prevalence of Beijing genotypes than other regions. Four isolates which harbored mutT4-48 also had mutT2-58 mutations. It is suggested that strains from the ancestors of modern Beijing lineage is circulating in Guangxi. Strains of modern Beijing lineage (OR=2.04) were more likely to acquire drug resistances than Lineage 4. Most of the lineage differentiation SNPs are related to cell wall biosynthetic pathways. Conclusions These results provided a higher resolution to better understand the history of transmission of M. tuberculosis from/to South China. And the incidence rate of tuberculosis might be affected by bacterial population structure shaped by demographic history. Our findings also support the hypothesis that Modern Beijing lineage originated in South China.


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