Death in four RHDV2 ‐vaccinated pet rabbits ( Oryctolagus cuniculus ) due to rabbit haemorrhagic disease virus 2 ( RHDV2 )

2021 ◽  
Author(s):  
G. G. Hänske ◽  
P. König ◽  
B. Schuhmann ◽  
C. A. Bertram ◽  
K. Müller
Keyword(s):  
Disease Virus ◽  
Oryctolagus Cuniculus ◽  
Rabbit Haemorrhagic Disease Virus ◽  
Rabbit Haemorrhagic Disease ◽  
Haemorrhagic Disease

scholarly journals Increased virulence of rabbit haemorrhagic disease virus associated with genetic resistance in wild Australian rabbits ( Oryctolagus cuniculus )

Virology ◽  
2014 ◽  
Vol 464-465 ◽  
pp. 415-423 ◽  
Author(s):  
Peter Elsworth ◽  
Brian D. Cooke ◽  
John Kovaliski ◽  
Ronald Sinclair ◽  
Edward C. Holmes ◽  
...  
Keyword(s):  
Disease Virus ◽  
Oryctolagus Cuniculus ◽  
Genetic Resistance ◽  
Rabbit Haemorrhagic Disease Virus ◽  
Rabbit Haemorrhagic Disease ◽  
Haemorrhagic Disease

Efficacy of a competitive enzyme-linked immunosorbent assay (cELISA) for estimating prevalence of immunity to rabbit haemorrhagic disease virus (RHDV) in populations of Australian wild rabbits (Oryctolagus cuniculus)

2002 ◽  
Vol 29 (6) ◽  
pp. 635 ◽  
Author(s):  
S. R. McPhee ◽  
D. Berman ◽  
A. Gonzales ◽  
K. L. Butler ◽  
J. Humphrey ◽  
...  
Keyword(s):  
Disease Virus ◽  
Oryctolagus Cuniculus ◽  
Limited Range ◽  
Enzyme Linked Immunosorbent Assay ◽  
Rabbit Haemorrhagic Disease Virus ◽  
Diagnostic Specificity ◽  
Predictive Equations ◽  
Rabbit Haemorrhagic Disease ◽  
Haemorrhagic Disease ◽  
Lethal Doses

This study examines the efficacy of a cELISA in estimating the prevalence of immunity to rabbit haemorrhagic disease virus (RHDV) in wild rabbits in Australia. Rabbits (n = 343) captured from six locations in Victoria and Queensland were experimentally challenged with a lethal oral dose (1500 50%-lethal doses, LD50) of RHDV. Death or survival to challenge was used to determine the performance characteristics of the test. The diagnostic specificity, sensitivity and accuracy were highly variable between sites, making it difficult to select a representative cut-off value for all sites that achieved a reasonable level of accuracy for the prediction of surviving and non-surviving rabbits. Estimates of prevalence of immunity were biased owing to effects of site of capture (time of capture) and age structure of the population. Using predictive equations, the best estimates of survival were ±10% but these results came from a limited range of sites, all of which had survival in the range 49–70%. The cELISA will determine whether the RHDV is present in rabbit populations but it should be used with caution when estimating the prevalence of immunity to RHDV. The cELISA may thus be limited in its application for examining the epidemiology of RHDV in Australian rabbit populations.

Temporal dynamics of rabbit haemorrhagic disease virus infection in a low-density population of wild rabbits (Oryctolagus cuniculus) in New Zealand

2006 ◽  
Vol 33 (4) ◽  
pp. 293 ◽  
Author(s):  
J. Henning ◽  
D. U. Pfeiffer ◽  
P. R. Davies ◽  
J. Meers ◽  
R. S. Morris
Keyword(s):  
New Zealand ◽  
Disease Virus ◽  
Oryctolagus Cuniculus ◽  
Temporal Dynamics ◽  
Population Decline ◽  
Adult Survivors ◽  
European Rabbit ◽  
Rabbit Haemorrhagic Disease Virus ◽  
Rabbit Haemorrhagic Disease ◽  
Haemorrhagic Disease

A longitudinal capture–mark–recapture study was conducted to determine the temporal dynamics of rabbit haemorrhagic disease (RHD) in a European rabbit (Oryctolagus cuniculus) population of low to moderate density on sand-hill country in the lower North Island of New Zealand. A combination of sampling (trapping and radio-tracking) and diagnostic (cELISA, PCR and isotype ELISA) methods was employed to obtain data weekly from May 1998 until June 2001. Although rabbit haemorrhagic disease virus (RHDV) infection was detected in the study population in all 3 years, disease epidemics were evident only in the late summer or autumn months in 1999 and 2001. Overall, 20% of 385 samples obtained from adult animals older than 11 weeks were seropositive. An RHD outbreak in 1999 contributed to an estimated population decline of 26%. A second RHD epidemic in February 2001 was associated with a population decline of 52% over the subsequent month. Following the outbreaks, the seroprevalence in adult survivors was between 40% and 50%. During 2000, no deaths from RHDV were confirmed and mortalities were predominantly attributed to predation. Influx of seronegative immigrants was greatest in the 1999 and 2001 breeding seasons, and preceded the RHD epidemics in those years. Our data suggest that RHD epidemics require the population immunity level to fall below a threshold where propagation of infection can be maintained through the population.

Myxoma virus and rabbit haemorrhagic disease virus 2 coinfection in a European wild rabbit (Oryctolagus cuniculus algirus), Portugal

2020 ◽  
Vol 8 (1) ◽  
pp. e001002 ◽  
Author(s):  
Carina Luisa Carvalho ◽  
Fábio Alexandre Abade dos Santos ◽  
Teresa Fagulha ◽  
Paulo Carvalho ◽  
Paula Mendonça ◽  
...  
Keyword(s):  
Disease Virus ◽  
Oryctolagus Cuniculus ◽  
Rare Event ◽  
Myxoma Virus ◽  
European Rabbit ◽  
Wild Rabbit ◽  
Rabbit Haemorrhagic Disease Virus ◽  
Sample Collection ◽  
Rabbit Haemorrhagic Disease ◽  
Haemorrhagic Disease

Myxoma virus (MYXV) and rabbit haemorrhagic disease virus 2 (RHDV2) are two major pathogens that affect the European rabbit (Oryctolagus cuniculus). Between August 2017 and August 2019, 1166 wild rabbits (971 legally hunted and 195 found dead) were tested by PCR-based methods for MYXV and RHDV2 within the scope of an ongoing surveillance programme on wild leporids in Portugal. Despite never having been reported before and being considered a rare event, coinfection by RHDV2 and MYXV was detected in one juvenile wild rabbit found dead in the Évora district located in Alentejo. The relative frequency of coinfection in the group of diseased rabbits (found dead in the field) was 0.52 per cent (1/195). The positivity percentage of each single virus was much higher, namely, 14.36 per cent (28/195) for MYXV and 55.38 per cent (108/195) for RHDV2, within the 2 years of sample collection considered.

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