SystemicScedosporium prolificansinfection in an 11-month-old Border collie with cobalamin deficiency secondary to selective cobalamin malabsorption (canine Imerslund-Gräsbeck syndrome)

K. Erles; A. Mugford; D. Barfield; T. Leeb; P. H. Kook

doi:10.1111/jsap.12678

SystemicScedosporium prolificansinfection in an 11-month-old Border collie with cobalamin deficiency secondary to selective cobalamin malabsorption (canine Imerslund-Gräsbeck syndrome)

Journal of Small Animal Practice ◽

10.1111/jsap.12678 ◽

2017 ◽

Vol 59 (4) ◽

pp. 253-256 ◽

Cited By ~ 6

Author(s):

K. Erles ◽

A. Mugford ◽

D. Barfield ◽

T. Leeb ◽

P. H. Kook

Keyword(s):

Cobalamin Deficiency ◽

Cobalamin Malabsorption

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Inherited Selective Intestinal Cobalamin Malabsorption and Cobalamin Deficiency in Dogs

Pediatric Research ◽

10.1203/00006450-199101000-00006 ◽

1991 ◽

Vol 29 (1) ◽

pp. 24-31 ◽

Cited By ~ 84

Author(s):

John C Fyfe ◽

Urs Giger ◽

Charles A Hall ◽

Peter F Jezyk ◽

Sherry A Klumpp ◽

...

Keyword(s):

Cobalamin Deficiency ◽

Cobalamin Malabsorption

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Cobalamin Deficiency in Elderly Patients: A Personal View

Current Gerontology and Geriatrics Research ◽

10.1155/2008/848267 ◽

2008 ◽

Vol 2008 ◽

pp. 1-7 ◽

Cited By ~ 7

Author(s):

Emmanuel Andrès ◽

Thomas Vogel ◽

Laure Federici ◽

Jacques Zimmer ◽

Ecaterina Ciobanu ◽

...

Keyword(s):

Helicobacter Pylori ◽

Elderly Patients ◽

Clinical Manifestations ◽

Vitamin B12 Deficiency ◽

The Elderly ◽

Cobalamin Deficiency ◽

Personal View ◽

B12 Deficiency ◽

Cobalamin Malabsorption

Cobalamin (vitamin B12) deficiency is particularly common in the elderly (>65 years of age) but is often unrecognized because its clinical manifestations are subtle; however, they are also potentially serious, particularly from a neuropsychiatric and hematological perspective. In the elderly, the main causes of cobalamin deficiency are pernicious anemia and food-cobalamin malabsorption. Food-cobalamin malabsorption syndrome is a disorder characterized by the inability to release cobalamin from food or its binding proteins. This syndrome is usually caused by atrophic gastritis, related or unrelated toHelicobacter pyloriinfection, and long-term ingestion of antacids and biguanides. Management of cobalamin deficiency with cobalamin injections is currently well documented but new routes of cobalamin administration (oral and nasal) are being studied, especially oral cobalamin therapy for food-cobalamin malabsorption.

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Methylmalonic Aciduria Secondary to Selective Cobalamin Malabsorption in a Yorkshire Terrier

Journal of the American Animal Hospital Association ◽

10.5326/jaaha-ms-6195 ◽

2015 ◽

Vol 51 (4) ◽

pp. 285-288 ◽

Cited By ~ 4

Author(s):

Gerard McLauchlan ◽

Angela McLaughlin ◽

Adrian C. Sewell ◽

Rory Bell

Keyword(s):

Clinical Signs ◽

Clinical Information ◽

Methylmalonic Aciduria ◽

Cobalamin Deficiency ◽

Vascular Abnormality ◽

Vascular Abnormalities ◽

Portosystemic Shunts ◽

Hereditary Nature ◽

Yorkshire Terrier ◽

Cobalamin Malabsorption

An 8 wk old male Yorkshire terrier was presented with a 2 wk history of recurrent hypoglycemia, lethargy, and seizures. Investigations revealed a marked increase in blood ammonia, low serum cobalamin, and increased levels of urinary methylmalonic acid (MMA) excretion. No liver vascular abnormality was detected. The patient was diagnosed with methylmalonic aciduria due to cobalamin malabsorption. The patient responded well to parenteral cobalamin administration, and the urinary MMA levels normalized rapidly following instigation of treatment. Due to the suspected hereditary nature of selective cobalamin deficiency, one sibling of this dog was screened and found to be normal. This is the first reported case of MMA secondary to hypocobalaminemia in Yorkshire terriers, and the second report of this disease in a dog in the United Kingdom. Given the fact that clinical signs of MMA are similar to those seen in dogs with portosystemic shunts and that Yorkshire terriers are predisposed to liver vascular abnormalities, this case report adds important clinical information to the current available literature.

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