The Th17/Treg cell balance: crosstalk among the immune system, bone and microbes in periodontitis

2021 ◽  
Author(s):  
Jianwen Deng ◽  
Chunting Lu ◽  
Qingtong Zhao ◽  
Kexiao Chen ◽  
Shuyuan Ma ◽  
...  
Keyword(s):  
Immune System ◽  
Treg Cell ◽  
Cell Balance

Essential oil from Pterodon emarginatus seeds ameliorates experimental autoimmune encephalomyelitis by modulating Th1/Treg cell balance

2014 ◽  
Vol 155 (1) ◽  
pp. 485-494 ◽  
Author(s):  
Thaís B. Alberti ◽  
Rodrigo Marcon ◽  
Maíra A. Bicca ◽  
Nádia R.B. Raposo ◽  
João B. Calixto ◽  
...  
Keyword(s):  
Essential Oil ◽  
Experimental Autoimmune Encephalomyelitis ◽  
Treg Cell ◽  
Autoimmune Encephalomyelitis ◽  
Cell Balance ◽  
Experimental Autoimmune

scholarly journals Rapamycin ameliorates CCl4-induced liver fibrosis in mice through reciprocal regulation of the Th17/Treg cell balance

2016 ◽  
Vol 14 (2) ◽  
pp. 1153-1161 ◽  
Author(s):  
Lei Gu ◽  
Wen-Sheng Deng ◽  
Xiao-Fei Sun ◽  
Hong Zhou ◽  
Qing Xu
Keyword(s):  
Liver Fibrosis ◽  
Treg Cell ◽  
Reciprocal Regulation ◽  
Cell Balance

scholarly journals Heme Oxygenase-1 Ameliorates Dextran Sulfate Sodium-induced Acute Murine Colitis by Regulating Th17/Treg Cell Balance

2014 ◽  
Vol 289 (39) ◽  
pp. 26847-26858 ◽  
Author(s):  
Liya Zhang ◽  
Yanjie Zhang ◽  
Wenwei Zhong ◽  
Caixia Di ◽  
Xiaoliang Lin ◽  
...  
Keyword(s):  
Treg Cell ◽  
Heme Oxygenase ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Heme Oxygenase 1 ◽  
Murine Colitis ◽  
Cell Balance

scholarly journals A new insight into tumor immune-evasion: Crosstalk between cancer stem cells and T regulatory cells

2020 ◽  
Author(s):  
Abhishek Dutta ◽  
Debomita Sengupta ◽  
Swastika Paul ◽  
Sourio Chakraborty ◽  
Tanya Das
Keyword(s):  
Stem Cells ◽  
T Cells ◽  
Immune System ◽  
Cancer Stem Cells ◽  
Treg Cell ◽  
Significant Role ◽  
Treg Cells ◽  
Cell Generation ◽  
Naïve T Cells

Cancer development is initiated, sustained, and aggravated by a rare population of cells, termed cancer stem cells (CSCs). Although CSCs are considered as a promising source of cells to orchestrate the immune system to work in favour of tumor, the detailed mechanisms underlying their immunomodulatory effects remain elusive. Recent reports indicate the contribution of exosomes, secreted from various cells, as mediators of cell-to-cell communication especially within the tumor microenvironment. We aimed at exploring the role of CSC-derived exosomes (CDEs) in reprogramming the host immune system by generating functional T-regulatory (Treg) cells, and at delineating the underlying mechanisms. Our results showed that CDEs play a significant role in generating CD4 + CD25 + FoxP3 + Treg cells from naive T-cells. A search for the underlying mechanism revealed the presence of FoxP3 protein in CDEs which was found to be transferred to the naïve T-cells. Exosomes from FoxP3-ablated CSCs failed to augment immuno-suppressive Treg cell generation confirming the significant role of the transported protein. In order to understand the contribution of CDE-FoxP3 in maintaining a heritably stable population of Treg cell we checked for the binding of CDE-FoxP3 on conserved non-coding sequence 2 (CNS2) region of FoxP3 promoter in T-naïve cells and found CDE-FoxP3 is indeed recruited to the CNS2 region generating stable and functionally suppressive Treg cells. These results raise the possibility that CSCs provide the initial trigger for immunosuppressive Treg cell generation and thus, breaching the deadly-liaison between them might be a promising strategy in breast cancer therapy.

scholarly journals Effect of uremic serum on Th17/Treg cell balance and endoplasmic reticulum stress in rats

2020 ◽  
Vol 131 ◽  
pp. 110705
Author(s):  
Dan Xiao ◽  
Shuiqin Li ◽  
Baosong Gui ◽  
Jin Han ◽  
Zhaoyang Duan ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Treg Cell ◽  
Uremic Serum ◽  
Cell Balance
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